Disease relevance of Flubenol

• The results suggest that flubendazole is safer and more effective than DEC in the treatment of onchocerciasis [1].
• Ocular complications (limbitis, punctate keratitis, and uveitis) were also common in the DEC group, whereas in the flubendazole group they consisted only of one new punctate opacity at day 4 in one subject [1].
• We suggest that neurologic complications of trichinosis should be treated by corticosteroids and flubendazole [2].
• Treatment of neurocysticercosis with flubendazole [3].
• Parameters of humoral and cellular immunity were assessed in 12 patients with alveolar echinococcosis (AE) of the liver before, during and after discontinuation of treatment with flubendazole (FZ) [4].

High impact information on Flubenol

• In addition, by 6 months none of the flubendazole subjects had intracorneal microfilariae, and only one had microfilariae in the anterior chamber, whereas the numbers of intraocular microfilariae in the DEC group had returned to pretreatment levels [1].
• Humoral and cellular immunity in patients with hepatic alveolar echinococcosis. A 2 year follow-up with and without flubendazole treatment [4].
• A comparison of the effects of flubendazole and thiabendazole on the larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei and Hymenolepis nana in mice [5].
• Aquatic toxicities of six benzimidazole-based anthelmintics-namely, albendazole, thiabendazole, flubendazole, febantel, fenbendazole, and oxfendazole-were evaluated with a marine bacterium, Vibrio fischeri, and a freshwater invertebrate, Daphnia magna [6].
• The first episode occurred 5 min after the first oral administration of Fluvermal (flubendazole) and the second occurred 10 min after cutaneous application of Betadine (povidone iodine solution) [7].

Chemical compound and disease context of Flubenol

• Mebendazole and flubendazole, administered in food at 500 ppm for 14 consecutive days, had a marked effect on one-year-old hydatid cysts of Echinococcus granulosus in mice infected with protoscolices of human origin [8].
• Delayed expression of toxicity observed for 21 d after 96-h exposure to fenbendazole and flubendazole was not notable, which might result from the relatively high elimination constants for the chemicals [6].
• There were too few cases of Trichuris and Ascaris infection to allow comparison of the two regimens, but flubendazole appeared to be as effective and the single day regimen more convenient than difetasone for trichuriasis and levamisole for ascariasis [9].

Biological context of Flubenol

• 1. We measured the distribution and depletion of residues of flubendazole and its major metabolites in breast muscle, thigh muscle and liver of guinea fowls during and after oral administration of the veterinary medicine Flubenol 5% at two doses [10].
• The ability of flubendazole to induce polyploidy may be part of the mechanism by which this compound induces morphological transformation [11].
• Similar concentrations of flubendazole and harringtonine induced chromosome damage in CHL cells and cytotoxicity and morphological transformation in 10T1/2 cells [11].
• Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite diffusion ability [12].
• The pharmacokinetics of mebendazole and flubendazole in animals and man [13].

Anatomical context of Flubenol

• Flubendazole also stopped the formation of gametes [14].
• Statistical differences in the frequency of loose feces and vomiting were not detected between the placebo group and flubendazole-treated groups [15].
• Chemoprophylactic activity of flubendazole against adult Brugia pahangi transplanted into the peritoneal cavity of jirds [16].
• The proportion of litters with anomalous fetuses was significantly increased at doses of 31.33 mg/kg per day and above when flubendazole was administered in deionized water, but increased at doses at four times lower when flubendazole was administered as in olive oil [17].
• All four harringtonine-transformed and all four flubendazole-transformed cell lines formed colonies in soft agar [11].

Associations of Flubenol with other chemical compounds

• Studies on anthelmintic effects of flubendazole and mebendazole on the rat lungworm Angiostrongylus cantonensis in mice and rats [18].
• The feed of 4 groups of 10 animals each was treated for 35 days with 500 ppm albendazole, flubendazole, mebendazole or praziquantel; 1 group of 10 jirds served as unmedicated controls [19].
• The anthelmintic effects of flubendazole (methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl] carbamate) (Janssen Pharmaceutica) were evaluated in jirds (Meriones unguiculatus) and cats (Felis cattus) infected with Brugia pahangi [20].
• Modulation of porcine biotransformation enzymes by anthelmintic therapy with fenbendazole and flubendazole [21].
• Fenbendazole (FBZ), flubendazole (FLBZ) and mebendazole (MBZ) are benzimidazole anthelmintics widely used in veterinary medicine [22].

Gene context of Flubenol

• Subgroup III (b): Mice received 1/3 dose of flubendazole 25 days post infection [23].
• This study is a trial to demonstrate the effect of the broad spectrum anthelmintic drug flubendazole (methyl 5-(p-fluoro-benzoyl)-2-benzimidazolecarbamate, CAS 31430-15-6), a mebendazole derivative, together with praziquantel (CAS 55268-74-1, EMBAY 8440, Biltricide) in murine schistosomiasis mansoni [23].

Analytical, diagnostic and therapeutic context of Flubenol

• Flubendazole residues in eggs after oral administration to laying hens: determination with reversed phase liquid chromatography [24].
• Flubendazole analysis was performed by reversed phase HPLC and UV detection at 250 nm (eggs) or 320 nm (feed) [24].
• All the mice infected with A. cantonensis were completely cured after treatment with flubendazole at 5 mg/kg/day for 6 days [5].
• Determination of the antifilarial drug UMF-078 and its metabolites UMF-060 and flubendazole in whole blood using high-performance liquid chromatography [25].
• Jirds were treated by the subcutaneous injection of 100 mg flubendazole per kilogram [16].

References