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Chemical Compound Review

Flubenol     methylN-[6-(4- fluorophenyl)carbonyl-1H...

Synonyms: Flumoxal, Flumoxane, Fluvermal, Flicum, Flumoxanal, ...
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Disease relevance of Flubenol


High impact information on Flubenol


Chemical compound and disease context of Flubenol


Biological context of Flubenol


Anatomical context of Flubenol


Associations of Flubenol with other chemical compounds


Gene context of Flubenol

  • Subgroup III (b): Mice received 1/3 dose of flubendazole 25 days post infection [23].
  • This study is a trial to demonstrate the effect of the broad spectrum anthelmintic drug flubendazole (methyl 5-(p-fluoro-benzoyl)-2-benzimidazolecarbamate, CAS 31430-15-6), a mebendazole derivative, together with praziquantel (CAS 55268-74-1, EMBAY 8440, Biltricide) in murine schistosomiasis mansoni [23].

Analytical, diagnostic and therapeutic context of Flubenol


  1. Comparison of flubendazole and diethylcarbamazine in treatment of onchocerciasis. Dominguez-Vazquez, A., Taylor, H.R., Greene, B.M., Ruvalcaba-Macias, A.M., Rivas-Alcala, A.R., Murphy, R.P., Beltran-Hernandez, F. Lancet (1983) [Pubmed]
  2. Multifocal central nervous system lesions in three patients with trichinosis. Ellrodt, A., Halfon, P., Le Bras, P., Halimi, P., Bourée, P., Dési, M., Caquet, R. Arch. Neurol. (1987) [Pubmed]
  3. Treatment of neurocysticercosis with flubendazole. Téllez-Girón, E., Ramos, M.C., Dufour, L., Montante, M., Tellez, E., Rodríguez, J., Gómez Méndez, F., Mireles, E. Am. J. Trop. Med. Hyg. (1984) [Pubmed]
  4. Humoral and cellular immunity in patients with hepatic alveolar echinococcosis. A 2 year follow-up with and without flubendazole treatment. Vuitton, D.A., Lasségue, A., Miguet, J.P., Hervé, P., Barale, T., Seillés, E., Capron, A. Parasite Immunol. (1984) [Pubmed]
  5. A comparison of the effects of flubendazole and thiabendazole on the larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei and Hymenolepis nana in mice. Maki, J., Yanagisawa, T. Parasitology (1983) [Pubmed]
  6. Ecological hazard assessment of major veterinary benzimidazoles: acute and chronic toxicities to aquatic microbes and invertebrates. Oh, S.J., Park, J., Lee, M.J., Park, S.Y., Lee, J.H., Choi, K. Environ. Toxicol. Chem. (2006) [Pubmed]
  7. Anaphylaxis to povidone in a child. Pedrosa, C., Costa, H., Oliveira, G., Romariz, J., Praça, F. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. (2005) [Pubmed]
  8. Chemotherapy of experimental echinococcosis in mice. Vanparijs, O. Ann. Trop. Med. Parasitol. (1986) [Pubmed]
  9. Clinical trial of flubendazole on hookworm, Trichuris trichiura and Ascaris lumbricoides infections. Bunnag, D., Harinasuta, T., Viravan, C., Jarupakorn, V., Chindanond, D., Desakorn, V. Southeast Asian J. Trop. Med. Public Health (1980) [Pubmed]
  10. Distribution and depletion of flubendazole and its metabolites in edible tissues of guinea fowl. De Ruyck, H., Daeseleire, E., Grijspeerdt, K., De Ridder, H., Van Renterghem, R., Huyghebaert, G. Br. Poult. Sci. (2004) [Pubmed]
  11. Induction of chromosomal aberrations, cytotoxicity, and morphological transformation in mammalian cells by the antiparasitic drug flubendazole and the antineoplastic drug harringtonine. Nianjun, H., Cerepnalkoski, L., Nwankwo, J.O., Dews, M., Landolph, J.R. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1994) [Pubmed]
  12. Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite diffusion ability. Moreno, L., Alvarez, L., Mottier, L., Virkel, G., Bruni, S.S., Lanusse, C. J. Vet. Pharmacol. Ther. (2004) [Pubmed]
  13. The pharmacokinetics of mebendazole and flubendazole in animals and man. Michiels, M., Hendriks, R., Heykants, J., van den Bossche, H. Archives internationales de pharmacodynamie et de thérapie. (1982) [Pubmed]
  14. In vitro studies on the effects of flubendazole against Toxocara canis and Ascaris suum. Hanser, E., Mehlhorn, H., Hoeben, D., Vlaminck, K. Parasitol. Res. (2003) [Pubmed]
  15. Evaluation of the safety of flubendazole premix in swine. Campbell, B., Newcomb, K., Guerrero, J. Am. J. Vet. Res. (1983) [Pubmed]
  16. Chemoprophylactic activity of flubendazole against adult Brugia pahangi transplanted into the peritoneal cavity of jirds. Denham, D.A., Brandt, E. J. Parasitol. (1980) [Pubmed]
  17. Effect of oral dosing vehicles on the developmental toxicity of flubendazole in rats. Yoshimura, H. Reprod. Toxicol. (2003) [Pubmed]
  18. Studies on anthelmintic effects of flubendazole and mebendazole on the rat lungworm Angiostrongylus cantonensis in mice and rats. Maki, J., Yanagisawa, T. J. Parasitol. (1986) [Pubmed]
  19. Chemotherapy of experimental Echinococcus multilocularis in jirds. Vanparijs, O. Parasitol. Res. (1990) [Pubmed]
  20. The anthelmintic effects of flubendazole on Brugia pahangi. Denham, D.A., Samad, R., Cho, S.Y., Suswillo, R.R., Skippins, S.C. Trans. R. Soc. Trop. Med. Hyg. (1979) [Pubmed]
  21. Modulation of porcine biotransformation enzymes by anthelmintic therapy with fenbendazole and flubendazole. Savlík, M., Fimanová, K., Szotáková, B., Lamka, J., Skálová, L. Res. Vet. Sci. (2006) [Pubmed]
  22. The effects of fenbendazole, flubendazole and mebendazole on activities of hepatic cytochromes P450 in pig. Baliharová, V., Velík, J., Savlík, M., Szotáková, B., Lamka, J., Tahotná, L., Skálová, L. J. Vet. Pharmacol. Ther. (2004) [Pubmed]
  23. Effect of simultaneous and/or consecutive administration of the broad spectrum anthelmintic flubendazole together with praziquantel in experimental Schistosoma mansoni infection. William, S., Guirguis, F., Nessim, N.G. Arzneimittel-Forschung. (2003) [Pubmed]
  24. Flubendazole residues in eggs after oral administration to laying hens: determination with reversed phase liquid chromatography. Kan, C.A., Keukens, H.J., Tomassen, M.J. The Analyst. (1998) [Pubmed]
  25. Determination of the antifilarial drug UMF-078 and its metabolites UMF-060 and flubendazole in whole blood using high-performance liquid chromatography. Ramanathan, S., Nair, N.K., Mansor, S.M., Navaratnam, V. J. Chromatogr. B, Biomed. Appl. (1994) [Pubmed]
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