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MeSH Review:

Fibromatosis, Gingival

Wright, H.J. et al., Baptista, I.P., Araujo, C.S. et al., Zhang, Y. et al., Shashi, V. et al., et al.

Saygun, Ozdemir, Günhan, Aydintuğ, Karslioğlu, Kasaboğlu, Tümer, Balci, Baptista, Coletta, Graner, Hart, Zhang, Gorry, Hart, Cooper, Marazita, Marks, Cortelli, Pallos,

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Disease relevance of Fibromatosis, Gingival

Cherubism, gingival fibromatosis, epilepsy, and mental deficiency (Ramon syndrome) with juvenile rheumatoid arthritis [1].
Hereditary gingival fibromatosis is frequently an isolated condition of little consequence apart from a cosmetic problem and occasional associations with hypertrichosis and/or epilepsy [2].
BACKGROUND/AIMS: Hereditary gingival fibromatosis is characterized by various degrees of attached gingival overgrowth [3].
Fibroblasts derived from tissue explants of dilantin-induced gingival hyperplasia and idiopathic gingival fibromatosis show distinct disparity in proliferative responsiveness to epidermal growth factor [4].
Hereditary gingival fibromatosis and sensorineural hearing loss in a 42-year-old man with Jones syndrome: Gingival fibromatosis is a rare disease, which can be seen as an isolated condition or associated with some uncommon syndromes [5].

High impact information on Fibromatosis, Gingival

A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1 [6].
A new locus for hereditary gingival fibromatosis (GINGF2) maps to 5q13-q22 [7].
Hereditary gingival fibromatosis (HGF, MIM 135300; approved gene symbol GINGF) is an oral disease characterized by enlargement of gingiva [8].
A young man was diagnosed as having Zimmerman-Laband syndrome (ZLS) on the basis of gingival fibromatosis and absence of nails on thumbs and halluces in addition to other anomalies [9].
Gingival fibromatosis with sensorineural hearing loss: an autosomal dominant trait [10].

Chemical compound and disease context of Fibromatosis, Gingival

Except for its asymmetric occurrence, this gingival enlargement strongly resembled phenytoin-induced enlargement or gingival fibromatosis [11].
The response of gingival fibroblasts cultured from humans with gingival fibromatosis to phenytoin (PHT) and nifedipine (NIF) was investigated [12].
It can be inherited (hereditary gingival fibromatosis [HGF]); associated with other diseases characterizing a syndrome; or induced as a side effect of systemic drugs, such as phenytoin, cyclosporin, or nifedipine [13].
As part of our studies to identify the gene responsible for hereditary gingival fibromatosis, GINGF (OMIM 135300), we have identified and cloned a novel human gene that contains the highly conserved methyltransferase domain characteristic of S-adenosylmethionine-dependent methyltransferases [14].
Collagen synthesis in idiopathic and dilantin-induced gingival fibromatosis [15].

Biological context of Fibromatosis, Gingival

An autosomal dominant form of hereditary gingival fibromatosis (HGF, MIM 135300) was recently mapped to chromosome 2p21 in a large Brazilian family and there was an earlier report of GF in a boy with a cytogenetic duplication involving 2p13-->p21 [16].
Furthermore, representation of the TGF-beta2-positive phenotype was reduced in hereditary gingival fibromatosis (P<0.01) but increased in DIGO (P<0.005) compared to controls [17].

Anatomical context of Fibromatosis, Gingival

OBJECTIVE: The objective of this study was to examine the histomorphometric features and evaluate the expression of epidermal growth factor (EGF) and transmembranic receptor (EGFr) and the proliferative potential of epithelial cells from normal and hereditary gingival fibromatosis (HGF) gingival tissues [18].

Gene context of Fibromatosis, Gingival

Absorbance measurements of the positive cell populations showed that the level of expression was significantly higher for TGF-beta1 in hereditary gingival fibromatosis (P<0.002) and significantly lower for TGF-beta3 in DIGO (P<0.03) [17].
Cells expressing TGF-beta2 were present at control levels in DIGO but were significantly reduced in hereditary gingival fibromatosis (P<0.02) [17].
BACKGROUND: Hereditary gingival fibromatosis (HGF) is an uncommon condition characterized by an accumulation of extracellular matrix resulting in a fibrotic enlargement of the gingiva [19].
Post-surgical follow-up after 20 months demonstrated a slight recurrence CONCLUSIONS: Hereditary gingival fibromatosis is a rare disorder characterized by the proliferative fibrous overgrowth of the gingival tissue [3].
Hereditary gingival fibromatosis and expression of Ki-67 antigen: a case report [20].

References

Cherubism, gingival fibromatosis, epilepsy, and mental deficiency (Ramon syndrome) with juvenile rheumatoid arthritis. Pina-Neto, J.M., Moreno, A.F., Silva, L.R., Velludo, M.A., Petean, E.B., Ribeiro, M.V., Athayde-Junior, L., Voltarelli, J.C. Am. J. Med. Genet. (1986) [Pubmed]
Hereditary gingival fibromatosis in a family with the Zimmermann-Laband syndrome. Bakaeen, G., Scully, C. J. Oral Pathol. Med. (1991) [Pubmed]
Hereditary gingival fibromatosis: a case report. Baptista, I.P. Journal of clinical periodontology. (2002) [Pubmed]
Fibroblasts derived from tissue explants of dilantin-induced gingival hyperplasia and idiopathic gingival fibromatosis show distinct disparity in proliferative responsiveness to epidermal growth factor. Huang, J.S., Chen, J.K., Chen, C.P., Juan, G., Bhatnagar, R.S., Liu, T.Z. The Kaohsiung journal of medical sciences. (1997) [Pubmed]
Hereditary gingival fibromatosis and sensorineural hearing loss in a 42-year-old man with Jones syndrome. Kasaboğlu, O., Tümer, C., Balci, S. Genetic counseling (Geneva, Switzerland) (2004) [Pubmed]
A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Hart, T.C., Zhang, Y., Gorry, M.C., Hart, P.S., Cooper, M., Marazita, M.L., Marks, J.M., Cortelli, J.R., Pallos, D. Am. J. Hum. Genet. (2002) [Pubmed]
A new locus for hereditary gingival fibromatosis (GINGF2) maps to 5q13-q22. Xiao, S., Bu, L., Zhu, L., Zheng, G., Yang, M., Qian, M., Hu, L., Liu, J., Zhao, G., Kong, X. Genomics (2001) [Pubmed]
Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21. Xiao, S., Wang, X., Qu, B., Yang, M., Liu, G., Bu, L., Wang, Y., Zhu, L., Lei, H., Hu, L., Zhang, X., Liu, J., Zhao, G., Kong, X. Genomics (2000) [Pubmed]
Zimmerman-Laband syndrome and profound mental retardation. Chodirker, B.N., Chudley, A.E., Toffler, M.A., Reed, M.H. Am. J. Med. Genet. (1986) [Pubmed]
Gingival fibromatosis with sensorineural hearing loss: an autosomal dominant trait. Hartsfield, J.K., Bixler, D., Hazen, R.H. Am. J. Med. Genet. (1985) [Pubmed]
Diffuse but unilateral gingival enlargement associated with von Recklinghausen neurofibromatosis: a case report. Bekisz, O., Darimont, F., Rompen, E.H. Journal of clinical periodontology. (2000) [Pubmed]
Proliferative response to phenytoin and nifedipine in gingival fibroblasts cultured from humans with gingival fibromatosis. Sano, M., Ohuchi, N., Inoue, T., Tono, K., Tachikawa, T., Kizawa, Y., Murakami, H. Fundamental & clinical pharmacology. (2004) [Pubmed]
Hereditary gingival fibromatosis: a systematic review. Coletta, R.D., Graner, E. J. Periodontol. (2006) [Pubmed]
Localization, genomic organization, and alternative transcription of a novel human SAM-dependent methyltransferase gene on chromosome 2p22-->p21. Zhang, Y., Gorry, M.C., Hart, P.S., Pettenati, M.J., Wang, L., Marks, J.J., Lu, X., Hart, T.C. Cytogenet. Cell Genet. (2001) [Pubmed]
Collagen synthesis in idiopathic and dilantin-induced gingival fibromatosis. Huang, J.S., Ho, K.Y., Chen, C.C., Wu, Y.M., Wang, C.C., Ho, Y.P., Liu, C.S. The Kaohsiung journal of medical sciences. (1997) [Pubmed]
Genetic heterogeneity of gingival fibromatosis on chromosome 2p. Shashi, V., Pallos, D., Pettenati, M.J., Cortelli, J.R., Fryns, J.P., von Kap-Herr, C., Hart, T.C. J. Med. Genet. (1999) [Pubmed]
TGF-beta isoforms and TGF-beta receptors in drug-induced and hereditary gingival overgrowth. Wright, H.J., Chapple, I.L., Matthews, J.B. J. Oral Pathol. Med. (2001) [Pubmed]
Histomorphometric characteristics and expression of epidermal growth factor and its receptor by epithelial cells of normal gingiva and hereditary gingival fibromatosis. Araujo, C.S., Graner, E., Almeida, O.P., Sauk, J.J., Coletta, R.D. J. Periodont. Res. (2003) [Pubmed]
Hereditary gingival fibromatosis: report of a five-generation family using cellular proliferation analysis. Martelli-Junior, H., Lemos, D.P., Silva, C.O., Graner, E., Coletta, R.D. J. Periodontol. (2005) [Pubmed]
Hereditary gingival fibromatosis and expression of Ki-67 antigen: a case report. Saygun, I., Ozdemir, A., Günhan, O., Aydintuğ, Y.S., Karslioğlu, Y. J. Periodontol. (2003) [Pubmed]

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