The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Byssinosis


High impact information on Byssinosis

  • A retrospective estimate of lifetime cotton dust exposure based on SDPRES correlated best with the prevalence of byssinosis (r = 0.797), although correlations with PD1 (r = 0.709) and SDPRES (r = 0.594) were also significant [6].
  • Low normal alpha-1-antitrypsin serum concentrations and MZ-phenotype are associated with byssinosis and familial allergy in cotton mill workers [7].
  • To understand the origins of this symptom of byssinosis, we exposed guinea pigs to respirable cotton dust and determined whether the resulting pulmonary obstruction was associated with alterations in the in vitro reactivity of the trachea to methacholine [8].
  • Compensation for byssinosis in Great Britain [9].
  • There was no relation between these symptoms and atopy, byssinosis, or dust concentration [10].

Chemical compound and disease context of Byssinosis


Biological context of Byssinosis

  • Previous reports suggest that byssinosis, an asthma-like condition among textile workers, may be mediated in part by histamine liberated following inhalation of dust [16].

Anatomical context of Byssinosis

  • Cotton bract tannin: a novel human T-lymphocyte mitogen and a possible causative agent of byssinosis [17].
  • Also, bacteria and fungi present in cotton do not in themselves cause byssinosis, but the endotoxins-heat-stable lipopolysaccharide-protein complexes contained in the cell wall of Gram-negative bacteria-are responsible for the development of this respiratory disease of workers on cotton, flax, and some other fibers [18].

Gene context of Byssinosis

  • Forty patients suffering from flax byssinosis were tissue-typed for HLA-A and -B antigens [19].
  • In study B, sera was collected on Monday morning and afternoon and was performed primarily to evaluate history of atopy and smoking as complicating factors in byssinosis [20].
  • Reduction in FEV 1.0 at the end of the first work shift after absence from work occured more often than byssinosis, which indicates the importance of this test for the early detection of effects of cotton dust exposure [21].
  • Byssinotic, NBS, and asymptomatic operatives all had reduced FEV1; observed mean liters (95% CI); predicted mean: byssinosis, 2.36 (2.09 to 2.63), 3.02; NBS, 2.94 (2.71 to 3.17), 3.29; and asymptomatic, 3.12 (2.95 to 3.29), 3.31 [22].
  • After a report in 1980 of the first three diagnosed locally cases and a preliminary epidemiological investigation that found little evidence of the disease, a survey was aimed at determining the prevalence of byssinosis in Hong Kong. Some 1776 workers in six cotton mills were studied using the standard MRC questionnaire and portable spirometers [23].

Analytical, diagnostic and therapeutic context of Byssinosis


  1. Toxicity to endothelial cells mediated by cotton bract tannin. Potential contribution to the pathogenesis of byssinosis. Johnson, C.M., Hanson, M.N., Rohrbach, M.S. Am. J. Pathol. (1986) [Pubmed]
  2. Enterobacter agglomerans lipopolysaccharide-induced changes in pulmonary surfactant as a factor in the pathogenesis of byssinosis. DeLucca, A.J., Brogden, K.A., Engen, R. J. Clin. Microbiol. (1988) [Pubmed]
  3. An overview of species differences in the effects of a water extract of cotton bract on isolated airway smooth muscle, and effects of E. coli lipopolysaccharide. Fedan, J.S., Robinson, V.A., Hay, D.W., Weber, K.C. Environ. Health Perspect. (1986) [Pubmed]
  4. Endotoxin-induced histamine hypersensitivity in mice. . . a model system for byssinosis? Greenblatt, G.A., Ziprin, R.L. American Industrial Hygiene Association journal. (1979) [Pubmed]
  5. First report of byssinosis in Hong Kong. Morgan, P.G., Ong, S.G. British journal of industrial medicine. (1981) [Pubmed]
  6. Respiratory symptoms and dust exposure in Lancashire cotton and man-made fiber mill operatives. Fishwick, D., Fletcher, A.M., Pickering, C.A., Niven, R.M., Faragher, E.B. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  7. Low normal alpha-1-antitrypsin serum concentrations and MZ-phenotype are associated with byssinosis and familial allergy in cotton mill workers. Sigsgaard, T., Brandslund, I., Rasmussen, J.B., Lund, E.D., Varming, H. Pharmacogenetics (1994) [Pubmed]
  8. Alteration in the modulatory role of respiratory epithelium after exposure of guinea pigs to respirable cotton dust. Smith, J.A., Frazer, D.G., Fedan, J.S. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  9. Compensation for byssinosis in Great Britain. Rooke, G.B. Chest (1981) [Pubmed]
  10. Ocular and nasal irritation in operatives in Lancashire cotton and synthetic fibre mills. Fishwick, D., Fletcher, A.M., Pickering, C.A., Niven, R.M., Faragher, E.B. Occupational and environmental medicine. (1994) [Pubmed]
  11. Byssinosis: thromboxane release from human platelets by cotton dust and bract extracts. Mundie, T.G., Ainsworth, S.K. Arch. Environ. Health (1985) [Pubmed]
  12. Platelet 5-hydroxytryptamine release and aggregation promoted by cotton bracts tannin. Rohrbach, M.S., Rolstad, R.A., Tracy, P.B., Russell, J.A. J. Lab. Clin. Med. (1984) [Pubmed]
  13. Role of histamine in the aetiology of byssinosis. I Blood histamine concentrations in workers exposed to cotton and flax dusts. Noweir, M.H., Abdel-Kader, H.M., Omran, F. British journal of industrial medicine. (1984) [Pubmed]
  14. The role of prostaglandin F2 alpha in byssinosis. Elissalde, M.H., Greenblatt, G.A., Ziprin, R.L. American Industrial Hygiene Association journal. (1980) [Pubmed]
  15. Orciprenaline chronic effect in byssinosis. Raucher, C., Szabo, V. Arhiv za higijenu rada i toksikologiju. (1981) [Pubmed]
  16. Histamine release from platelets for assay of byssinogenic substances in cotton mill dust and related materials. Ainsworth, S.K., Neuman, R.E., Harley, R.A. British journal of industrial medicine. (1979) [Pubmed]
  17. Cotton bract tannin: a novel human T-lymphocyte mitogen and a possible causative agent of byssinosis. Vuk-Pavlović, Z., Russell, J.A., Rohrbach, M.S. Int. Arch. Allergy Appl. Immunol. (1988) [Pubmed]
  18. Bactericidal treatment of raw cotton as the method of byssinosis prevention. Hend, I.M., Milnera, M., Milnera, S.M. AIHA journal : a journal for the science of occupational and environmental health and safety. (2003) [Pubmed]
  19. HLA antigen frequencies in flax byssinosis patients. Middleton, D., Logan, J.S., Magennis, B.P., Nelson, S.D. British journal of industrial medicine. (1979) [Pubmed]
  20. Byssinosis: serum immunoglobulin and complement concentrations in cotton mill workers. Mundie, T.G., Pilia, P.A., Ainsworth, S.K. Arch. Environ. Health (1985) [Pubmed]
  21. An environmental and medical study of byssinosis and other respiratory conditions in the cotton textile industry in Egypt. Noweir, M.H., Noweir, K.H., Osman, H.A., Moselhi, M. Am. J. Ind. Med. (1984) [Pubmed]
  22. Lung function, bronchial reactivity, atopic status, and dust exposure in Lancashire cotton mill operatives. Fishwick, D., Fletcher, A.M., Pickering, C.A., Niven, R.M., Faragher, E.B. Am. Rev. Respir. Dis. (1992) [Pubmed]
  23. Byssinosis in Hong Kong. Ong, S.G., Lam, T.H., Wong, C.M., Ma, P.L., Lam, S.K., O'Kelly, F.J. British journal of industrial medicine. (1985) [Pubmed]
  24. Differential diagnosis of byssinosis by blood histamine and pulmonary function test: a review and an appraisal. Venkatakrishna-Bhatt, H., Mohan-Rao, N., Panchal, G.M. International journal of toxicology. (2001) [Pubmed]
WikiGenes - Universities