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MeSH Review

Junin Virus

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Disease relevance of Junin Virus

  • Because Junin virus (JV) experimental encephalitis of mice and rats is characterized by mild histopathological changes that do not seem to justify per se lethality after intracerebral infection, such a murine model seems adequate to investigate the potential role of inducible nitric oxide synthase (iNOS) as a pathogenic factor [1].
  • Ribavirin, a broad spectrum antiviral agent, is effective in the treatment of other viral hemorrhagic fevers, and the studies done with Junin virus infections to date indicate that this drug may also have a beneficial effect in Argentine hemorrhagic fever [2].
  • When Vero cells infected with Junín virus are cultured in the presence of 16 mM glucosamine, no infectious virus is produced and no surface antigens or virions are detected [3].

High impact information on Junin Virus

  • In addition, we demonstrate that the Junín virus GP-C signal peptide subunit is myristoylated at its N-terminal glycine [4].
  • Polyacrylamide gel electrophoresis of purified Junin virus revealed six distinct structural polypeptides, two major and four minor ones [5].
  • When ribavirin was administered intramuscularly at the time of experimental infection with the lethal P3790 strain of Junin virus, all animals were protected from clinical disease [6].
  • The induction of endogenous interferon (IFN) was studied in 28 cases of Argentine hemorrhagic fever (AHF), a severe systemic disease caused by Junin virus [7].
  • The G2 fusion subunit of the Junín virus envelope glycoprotein GP-C contains two hydrophobic heptad-repeat regions that are postulated to form a six-helix bundle structure required for the membrane fusion activity of Class I viral fusion proteins [8].

Chemical compound and disease context of Junin Virus


Biological context of Junin Virus

  • In this paper, we report the nucleotide sequence of the glycoprotein precursor gene (GPC) of the Junin virus vaccine strain (Candid #1) and its flanking untranslated regions [14].

Anatomical context of Junin Virus


Gene context of Junin Virus


Analytical, diagnostic and therapeutic context of Junin Virus


  1. Junin virus-induced astrocytosis is impaired by iNOS inhibition. Gómez, R.M., Yep, A., Schattner, M., Berría, M.I. J. Med. Virol. (2003) [Pubmed]
  2. Antiviral treatment of Argentine hemorrhagic fever. Enria, D.A., Maiztegui, J.I. Antiviral Res. (1994) [Pubmed]
  3. Effect of glucosamine on the replication of the arenavirus Junín in Vero cells. Martínez Peralta, L.A., León, M.E., Coto, C.E., Laguens, R.P. Intervirology (1979) [Pubmed]
  4. The signal peptide of the Junín arenavirus envelope glycoprotein is myristoylated and forms an essential subunit of the mature G1-G2 complex. York, J., Romanowski, V., Lu, M., Nunberg, J.H. J. Virol. (2004) [Pubmed]
  5. Junin virus structural proteins. De Martínez Segovia, Z.M., De Mitri, M.I. J. Virol. (1977) [Pubmed]
  6. Ribavirin prophylaxis and therapy for experimental argentine hemorrhagic fever. McKee, K.T., Huggins, J.W., Trahan, C.J., Mahlandt, B.G. Antimicrob. Agents Chemother. (1988) [Pubmed]
  7. Endogenous interferon in Argentine hemorrhagic fever. Levis, S.C., Saavedra, M.C., Ceccoli, C., Falcoff, E., Feuillade, M.R., Enria, D.A., Maiztegui, J.I., Falcoff, R. J. Infect. Dis. (1984) [Pubmed]
  8. Genetic analysis of heptad-repeat regions in the G2 fusion subunit of the Junín arenavirus envelope glycoprotein. York, J., Agnihothram, S.S., Romanowski, V., Nunberg, J.H. Virology (2005) [Pubmed]
  9. Junin virus monoclonal antibodies: characterization and cross-reactivity with other arenaviruses. Sanchez, A., Pifat, D.Y., Kenyon, R.H., Peters, C.J., McCormick, J.B., Kiley, M.P. J. Gen. Virol. (1989) [Pubmed]
  10. Brain inflammatory exudate in Junin virus-infected rats: its characterization by the immunoperoxidase (PAP) technique. Lascano, E.F., Blejer, J.L., Galassi, N.V., Nejamkis, M.R. J. Neuroimmunol. (1986) [Pubmed]
  11. Formalin inactivated Junin virus: immunogenicity and protection assays. Videla, C., Carballal, G., Remorini, P., La Torre, J. J. Med. Virol. (1989) [Pubmed]
  12. Myristic acid analogs are inhibitors of Junin virus replication. Cordo, S.M., Candurra, N.A., Damonte, E.B. Microbes Infect. (1999) [Pubmed]
  13. Replication of Junin virus in the presence of tunicamycin. Padula, P.J., de Martínez Segovia, Z.M. Intervirology (1984) [Pubmed]
  14. The glycoprotein precursor gene of the attenuated Junin virus vaccine strain (Candid #1). Ghiringhelli, P.D., Albarino, C.G., Piboul, M., Romanowski, V. Am. J. Trop. Med. Hyg. (1997) [Pubmed]
  15. Glial fibrillary acidic protein (GFAP) immunochemical profile after junin virus infection of rat cultured astrocytes. Iacono, R.F., Nessi de Aviñón, A., Rosetti, F.A., Berría, M.I. Neurosci. Lett. (1995) [Pubmed]
  16. Zinc-binding properties of Junín virus nucleocapsid protein. Tortorici, M.A., Ghiringhelli, P.D., Lozano, M.E., Albariño, C.G., Romanowski, V. J. Gen. Virol. (2001) [Pubmed]
  17. Effect of inhibitors of the intracellular exocytic pathway on glycoprotein processing and maturation of Junin virus. Candurra, N.A., Damonte, E.B. Arch. Virol. (1997) [Pubmed]
  18. Immunosuppression in experimental Junin virus infection of mice. Giovanniello, O.A., Nejamkis, M.R., Galassi, N.V., Nota, N.R. Intervirology (1980) [Pubmed]
  19. Description of a BHK/21 cell line persistently infected with Junin virus: its use in diagnostic procedures. Carballal, G., Cossio, P.M., Rabinovich, A., Oubiña, J., Arana, R.M. Intervirology (1980) [Pubmed]
  20. Effect of ribavirin and tributylribavirin on argentine hemorrhagic fever (Junin virus) in guinea pigs. Kenyon, R.H., Canonico, P.G., Green, D.E., Peters, C.J. Antimicrob. Agents Chemother. (1986) [Pubmed]
  21. Biological properties of Junin virus proteins. I. Identification of the immunogenic glycoprotein. Cresta, B., Padula, P., de Martinez Segovia, M. Intervirology (1980) [Pubmed]
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