Disease relevance of Conization

• A comparison of cold knife, CO2 laser, and electrosurgical loop conization in the treatment of cervical intraepithelial neoplasia [1].
• Intraoperative and postoperative complications related to CO2 laser conization and cold knife conization were compared [2].
• In 3 cases evaluated by cervical conization, histologic slides showed tubal metaplasia [3].

High impact information on Conization

• The overall sensitivity of HC in detecting high-grade SIL on cervical scrapes and conization samples was 71.2%, while its positive predictive value was 17.8% [4].
• With the use of a modified Storey method for determining codon 72 allelotypes, DNA was examined from 431 microdissected, formalin-fixed, archival cervical conization specimens ranging from low-grade squamous lesions to invasive cancer [5].
• High-risk HPV testing was realized by the Hybrid Capture II system before and 3 months after conization [6].
• High-grade glandular intraepithelial lesions developed in two (0.05%) patients 14 and 17 years after conization [7].
• METHODS: Cervical brushings were taken from the cervices of hysterectomy and conization or loop electrical excision specimens and analyzed for HPV nucleic acids by polymerase chain reaction and restriction fragment length polymorphism analysis [8].

Chemical compound and disease context of Conization

• Thus in our experience, CO2 laser conization is more effective for clinical diagnosis and treating of cervical intraepithelial neoplasia [2].

Biological context of Conization

• Hemostasis in cold-knife conization. Effects and side effects of Glypressin, a long-acting analogue of lysine-vasopressin [9].
• On the other hand reduction in heart rate (values before conization compared with values during conization) was more pronounced when N alpha-triglycyl-lysine vasopressin was used, but there was no difference in absolute values between the two groups during conization [10].
• The finding of increased liberation of plasminogen activators strengthens the rationale for administration of synthetic inhibitors of fibrinolysis to reduce the frequency of bleeding complications at conization [11].

Anatomical context of Conization

• The outcome of pregnancy after CO2 laser conisation of the cervix [12].
• A comparison is made of the histologic changes in the cervical epithelium and stroma following CO2 laser conization and office excisional biopsy of cervical tissue using the loop electrosurgical excision procedure [13].

Associations of Conization with chemical compounds

• Comparison of specimens removed by CO2 laser conization and the loop electrosurgical excision procedure [13].
• Carbon dioxide laser for combination excisional-vaporization conization [14].
• All patients had a history of intrauterine diethylstilbestrol exposure, and three patients had also undergone cervical conization [15].
• In a double-blind, randomized study, 50 patients undergoing conization were treated with either lysine-vasopressin (LVP) or its longer-acting analogue Glypressin [9].
• Severe cervical dysplasia. Control by biopsies or primary conization? A comparative study [16].

Gene context of Conization

• Plasminogen activator and fibrinogen/fibrin degradation products at conization of the uterine cervix [11].
• A persistently elevated (greater than 5.0 ng. milliter) plasma CEA value following conization was associated with residual CIN in the cervix [17].
• Two patients developed in situ carcinoma (CIS) of the vagina 12 months after CH for lesions on conization that invaded less than 1 mm [18].
• Ninety-three cervical conization specimens with condyloma or intraepithelial neoplasia were stained by the peroxidase-antiperoxidase technique for involucrin [19].
• MATERIALS AND METHODS: 16 conization specimens (8 from HIV-infected and 8 from non-HIV-infected patients) of HPV-related, high-grade SIL were selected [20].

Analytical, diagnostic and therapeutic context of Conization

• All patients underwent high-risk human papillomavirus deoxyribonucleic acid testing by the Hybrid Capture II (Digene Corporation, Gaithersburg, MD) system before conization and at the time of hysterectomy (within 2-7 weeks after conization) [21].
• We investigated the treatment effect on oxidative status from patients submitted to radiotherapy or conization surgery to high-grade SIL (squamous intraepithelial lesion) treatment, and oxidative profile from patients newly diagnosed for uterine cervix cancer, without treatment [22].
• Treatments considered were large loop excision of the transformation zone (LLETZ) cold knife conization, and CO2 laser vaporization [23].
• Additional cervical electron microscopy specimens were recovered from the speculum during pulsed CO2 laser treatment at 13 W average power during conization [24].
• The use of the CO2 laser has been shown to reduce the high morbidity associated with cervical conization, but, like cold-knife conization, laser excisional procedures are still usually done in an operating room under general anesthesia [25].

References