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Disease relevance of Conization


High impact information on Conization

  • The overall sensitivity of HC in detecting high-grade SIL on cervical scrapes and conization samples was 71.2%, while its positive predictive value was 17.8% [4].
  • With the use of a modified Storey method for determining codon 72 allelotypes, DNA was examined from 431 microdissected, formalin-fixed, archival cervical conization specimens ranging from low-grade squamous lesions to invasive cancer [5].
  • High-risk HPV testing was realized by the Hybrid Capture II system before and 3 months after conization [6].
  • High-grade glandular intraepithelial lesions developed in two (0.05%) patients 14 and 17 years after conization [7].
  • METHODS: Cervical brushings were taken from the cervices of hysterectomy and conization or loop electrical excision specimens and analyzed for HPV nucleic acids by polymerase chain reaction and restriction fragment length polymorphism analysis [8].

Chemical compound and disease context of Conization


Biological context of Conization


Anatomical context of Conization

  • The outcome of pregnancy after CO2 laser conisation of the cervix [12].
  • A comparison is made of the histologic changes in the cervical epithelium and stroma following CO2 laser conization and office excisional biopsy of cervical tissue using the loop electrosurgical excision procedure [13].

Associations of Conization with chemical compounds


Gene context of Conization

  • Plasminogen activator and fibrinogen/fibrin degradation products at conization of the uterine cervix [11].
  • A persistently elevated (greater than 5.0 ng. milliter) plasma CEA value following conization was associated with residual CIN in the cervix [17].
  • Two patients developed in situ carcinoma (CIS) of the vagina 12 months after CH for lesions on conization that invaded less than 1 mm [18].
  • Ninety-three cervical conization specimens with condyloma or intraepithelial neoplasia were stained by the peroxidase-antiperoxidase technique for involucrin [19].
  • MATERIALS AND METHODS: 16 conization specimens (8 from HIV-infected and 8 from non-HIV-infected patients) of HPV-related, high-grade SIL were selected [20].

Analytical, diagnostic and therapeutic context of Conization


  1. A comparison of cold knife, CO2 laser, and electrosurgical loop conization in the treatment of cervical intraepithelial neoplasia. Lewis, P.L., Lashgari, M. Journal of gynecologic surgery. (1994) [Pubmed]
  2. CO 2 laser conization for cervical intraepithelial neoplasia: a comparison with cold knife conization during pregnancy. Moriyama, M., Iwanari, O., Nakayama, S., Yoshino, N., Date, Y., Miyako, J., Ryukou, K., Kitao, M. Journal of clinical laser medicine & surgery. (1991) [Pubmed]
  3. Microglandular endocervical hyperplasia and tubal metaplasia: pitfalls in the diagnosis of adenocarcinoma on cervical smears. Selvaggi, S.M., Haefner, H.K. Diagn. Cytopathol. (1997) [Pubmed]
  4. Comparative analysis of human papillomavirus detection by hybrid capture assay and routine cytologic screening to detect high-grade cervical lesions. Clavel, C., Bory, J.P., Rihet, S., Masure, M., Duval-Binninger, I., Putaud, I., Lorenzato, M., Quereux, C., Birembaut, P. Int. J. Cancer (1998) [Pubmed]
  5. Polymorphism at codon 72 of p53 is not associated with cervical cancer risk. Malcolm, E.K., Baber, G.B., Boyd, J.C., Stoler, M.H. Mod. Pathol. (2000) [Pubmed]
  6. Value of human papillomavirus testing after conization by loop electrosurgical excision for high-grade squamous intraepithelial lesions. Houfflin Debarge, V., Collinet, P., Vinatier, D., Ego, A., Dewilde, A., Boman, F., Leroy, J.L. Gynecol. Oncol. (2003) [Pubmed]
  7. Cervical intraepithelial neoplasia III: long-term outcome after cold-knife conization with clear margins. Reich, O., Pickel, H., Lahousen, M., Tamussino, K., Winter, R. Obstetrics and gynecology. (2001) [Pubmed]
  8. Prevalence and histologic significance of cervical human papillomavirus DNA detected in women at low and high risk for cervical neoplasia. Shen, L.H., Rushing, L., McLachlin, C.M., Sheets, E.E., Crum, C.P. Obstetrics and gynecology. (1995) [Pubmed]
  9. Hemostasis in cold-knife conization. Effects and side effects of Glypressin, a long-acting analogue of lysine-vasopressin. Irestedt, L., Thomassen, P.A., Vilhardt, H. Acta obstetricia et gynecologica Scandinavica. (1986) [Pubmed]
  10. Comparison between lysine vasopressin and a long-acting analogue (N alpha-triglycyl-lysine vasopressin) used as local hemostatic agents for conization. Rundqvist, E., Allen, D., Larsson, G. Acta obstetricia et gynecologica Scandinavica. (1988) [Pubmed]
  11. Plasminogen activator and fibrinogen/fibrin degradation products at conization of the uterine cervix. Larsson, G., Astedt, B. Acta obstetricia et gynecologica Scandinavica. (1986) [Pubmed]
  12. The outcome of pregnancy after CO2 laser conisation of the cervix. Murdoch, J.B., Morgan, P.R., Lopes, A., Monaghan, J.M. British journal of obstetrics and gynaecology. (1994) [Pubmed]
  13. Comparison of specimens removed by CO2 laser conization and the loop electrosurgical excision procedure. Wright, T.C., Richart, R.M., Ferenczy, A., Koulos, J. Obstetrics and gynecology. (1992) [Pubmed]
  14. Carbon dioxide laser for combination excisional-vaporization conization. Baggish, M.S., Dorsey, J.H. Am. J. Obstet. Gynecol. (1985) [Pubmed]
  15. Transvaginal cerclage under ultrasound guidance in cases of severe cervical hypoplasia. Ludmir, J., Jackson, G.M., Samuels, P. Obstetrics and gynecology. (1991) [Pubmed]
  16. Severe cervical dysplasia. Control by biopsies or primary conization? A comparative study. Westergaard, L., Nørgaard, M. Acta obstetricia et gynecologica Scandinavica. (1981) [Pubmed]
  17. Carcinoembryonic antigen in intraepithelial neoplasia of the uterine cervix. van Nagell, J.R., Meeker, W.R., Parker, J.C., Kashmiri, R., McCollum, V. Am. J. Obstet. Gynecol. (1976) [Pubmed]
  18. Early invasive carcinoma of the cervix. Jones, W.B., Mercer, G.O., Lewis, J.L., Rubin, S.C., Hoskins, W.J. Gynecol. Oncol. (1993) [Pubmed]
  19. Immunoreactivity of involucrin in cervical condyloma and intraepithelial neoplasia. Saito, K., Saito, A., Fu, Y.S., Cheng, L., Hilborne, L.H. Int. J. Gynecol. Pathol. (1986) [Pubmed]
  20. Local impairment of immunoreactivity in HIV-infected women with HPV-related squamous intraepithelial lesions of the cervix. Barberis, M.C., Vago, L., Cecchini, G., Bramerio, M., Banfi, G., D'Amico, M., Cannone, M. Tumori. (1998) [Pubmed]
  21. Value of human papillomavirus deoxyribonucleic acid testing after conization in the prediction of residual disease in the subsequent hysterectomy specimen. Lin, C.T., Tseng, C.J., Lai, C.H., Hsueh, S., Huang, K.G., Huang, H.J., Chao, A. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  22. Oxidative status in patients submitted to conization and radiation treatments for uterine cervix neoplasia. Maldonado, P.A., Negrini, L.A., Kaizer, R.R., Zanin, R.F., Araújo, M.d.o. .C., Battisti, V., Morsch, V.M., Schetinger, M.R. Clin. Chim. Acta (2006) [Pubmed]
  23. Decision-making in the colposcopy clinic--a critical analysis. Bornstein, J., Yaakov, Z., Pascal, B., Faktor, J., Baram, A., Zarfati, D., Abramovici, H. Eur. J. Obstet. Gynecol. Reprod. Biol. (1999) [Pubmed]
  24. Studies on the transmission of viral disease via the CO2 laser plume and ejecta. Wisniewski, P.M., Warhol, M.J., Rando, R.F., Sedlacek, T.V., Kemp, J.E., Fisher, J.C. The Journal of reproductive medicine. (1990) [Pubmed]
  25. Conization of the cervix with the CO2 laser as an office procedure. Indman, P.D. The Journal of reproductive medicine. (1985) [Pubmed]
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