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MeSH Review

Mobiluncus

 
 
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Disease relevance of Mobiluncus

 

High impact information on Mobiluncus

  • Metronidazole, tinidazole, and Nile blue A may be of value in the development of a selective agar for Mobiluncus species [6].
  • In contrast, all isolates of Bacteroides, other than the Bact. fragilis group, and all Mobiluncus isolates were inhibited by 2 mg/l of roxithromycin or less [7].
  • The MIC of metronidazole against the Mobiluncus spp. varied between 0.5 and greater than or equal to 128 mg/l (median MIC 16 mg/l) and the hydroxy metabolite showed little increased activity (median MIC also 16 mg/l) [8].
  • METHODS: A multiple PCR assay was developed using primers specific to 16S ribosomal deoxyribonucleic acid (DNA) (Mobiluncus mulieris and Mobiluncus curtisii), nanH (Bacteroides fragilis), and an internal spacer region of ribosomal DNA (Gardnerella vaginalis) [9].
  • Mobiluncus spp. morphotypes were 99.0% specific and 52.1% sensitive and proline aminopeptidase activity in vaginal fluid was 84.4% sensitive and 70.2% specific for diagnosis [10].
 

Chemical compound and disease context of Mobiluncus

 

Gene context of Mobiluncus

  • The greater sensitivity of the proline aminopeptidase assay, especially in patients without Mobiluncus morphotypes, proves its superiority [13].
  • Mobiluncus species were isolated on enriched Schaedler agar and RLK agar plates under anaerobic conditions [14].
 

Analytical, diagnostic and therapeutic context of Mobiluncus

References

  1. Occurrence of clindamycin-resistant anaerobic bacteria isolated from cultures taken following clindamycin therapy. Ohm-Smith, M.J., Sweet, R.L., Hadley, W.K. Antimicrob. Agents Chemother. (1986) [Pubmed]
  2. Characterization of unusual tetracycline-resistant gram-positive bacteria. Roberts, M.C., Moncla, B.J., Hillier, S.L. Antimicrob. Agents Chemother. (1991) [Pubmed]
  3. Tetracycline resistance and tetM in pathogenic urogenital bacteria. Roberts, M.C., Hillier, S.L., Hale, J., Holmes, K.K., Kenny, G.E. Antimicrob. Agents Chemother. (1986) [Pubmed]
  4. Newly recovered and delineated microbial species of the human genital tract. Hammann, R. Infection (1989) [Pubmed]
  5. In vitro activity of azithromycin and erythromycin against organisms associated with bacterial vaginosis and chancroid. Jones, B.M., Kinghorn, G.R., Duerden, B.I. Eur. J. Clin. Microbiol. Infect. Dis. (1988) [Pubmed]
  6. Susceptibility of Mobiluncus species to 23 antimicrobial agents and 15 other compounds. Spiegel, C.A. Antimicrob. Agents Chemother. (1987) [Pubmed]
  7. In-vitro comparison of roxithromycin and erythromycin against 900 anaerobic bacterial strains. Dubreuil, L. J. Antimicrob. Chemother. (1987) [Pubmed]
  8. In-vitro and in-vivo activity of metronidazole against Gardnerella vaginalis, Bacteroides spp. and Mobiluncus spp. in bacterial vaginosis. Jones, B.M., Geary, I., Alawattegama, A.B., Kinghorn, G.R., Duerden, B.I. J. Antimicrob. Chemother. (1985) [Pubmed]
  9. A multiplex polymerase chain reaction-based diagnostic method for bacterial vaginosis. Obata-Yasuoka, M., Ba-Thein, W., Hamada, H., Hayashi, H. Obstetrics and gynecology. (2002) [Pubmed]
  10. Bacterial vaginosis: diagnostic and pathogenetic findings during topical clindamycin therapy. Livengood, C.H., Thomason, J.L., Hill, G.B. Am. J. Obstet. Gynecol. (1990) [Pubmed]
  11. Chemotaxis inhibition by Gardnerella vaginalis and succinate producing vaginal anaerobes: composition of vaginal discharge associated with G vaginalis. Sturm, A.W. Genitourinary medicine. (1989) [Pubmed]
  12. Antigenic and biochemical characteristics of Mobiluncus mulieris and Mobiluncus curtisii. Skarin, A. Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology. (1986) [Pubmed]
  13. Proline aminopeptidase activity as a rapid diagnostic test to confirm bacterial vaginosis. Thomason, J.L., Gelbart, S.M., Wilcoski, L.M., Peterson, A.K., Jilly, B.J., Hamilton, P.R. Obstetrics and gynecology. (1988) [Pubmed]
  14. Mobiluncus species in gynaecological and obstetric infections: antimicrobial resistance and prevalence in a Turkish population. Bahar, H., Torun, M.M., Oçer, F., Kocazeybek, B. Int. J. Antimicrob. Agents (2005) [Pubmed]
  15. Is there a causal connection between motile curved rods, Mobiluncus species, and bleeding complications? Larsson, P.G., Bergman, B.B. Am. J. Obstet. Gynecol. (1986) [Pubmed]
 
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