The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

AG-D-84699     (2S,3S,4S)-4-[(6R)-6- carboxyhepta-2,4-dien...

Synonyms: CTK8F9359, 14277-97-5
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of C13732

  • In late 1987 there was an outbreak in Canada of gastrointestinal and neurologic symptoms after the consumption of mussels found to be contaminated with domoic acid, which is structurally related to the excitatory neurotransmitter glutamate [1].
  • An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid [2].
  • Such findings reveal that monitoring of mussel toxicity alone does not necessarily provide adequate warning of DA entering the food web at levels sufficient to harm marine wildlife and perhaps humans [3].
  • Domoic acid (DA), a potent neurotoxin, administered intravenously (0.75 mg/kg body weight) in adult rats evoked seizures accompanied by nerve cell damage in the present study [4].
  • After intraperitoneal (i.p.) administration of domoic acid (6 mg/kg), electrographic spikes appeared at increasing frequency, progressing to high-amplitude (0.1-0.8 mV) continuous seizure activity (status epilepticus) [5].

Psychiatry related information on C13732


High impact information on C13732


Chemical compound and disease context of C13732


Biological context of C13732


Anatomical context of C13732

  • Neuronal degeneration followed by detection of nitric oxide (NO)-producing neurons of the hippocampus was investigated at 4 h, 16 h, 24 h, 2 days, 5 days, and 14 days after administration of domoic acid (DA), in the present study [19].
  • Subcellular fractionation and lesioning experiments using the excitotoxin domoic acid indicated that the alpha-amino-3-hydroxyl-5-methyl-isoxazole-4-propionate receptor subunits were associated with postsynaptic membranes [20].
  • Results indicate that the primary health effects associated with domoic acid toxicity can be averted in populations of concern and for others consuming crabs or clams less frequently (or in lesser quantity) if domoic acid contaminant concentration does not exceed 30 mg/kg in the hepatopancreas and viscera of dungeness crabs or 20 mg/kg in clams [21].
  • 3. In the isolated dorsal root fibre, domoic acid caused the most significant depolarization [22].
  • Induction of inducible nitric oxide synthase expression in activated microglia following domoic acid (DA)-induced neurotoxicity in the rat hippocampus [23].

Associations of C13732 with other chemical compounds


Gene context of C13732

  • Distribution of NADPH-diaphorase and expression of nNOS, N-methyl-D-aspartate receptor (NMDAR1) and non-NMDA glutamate receptor (GlutR2) genes in the neurons of the hippocampus after domoic acid-induced lesions in adult rats [19].
  • Using DA-3 antibody, an indirect competitive enzyme immunoassay (idc-EIA) was developed for measurement of domoic acid [28].
  • For production of monoclonal antibodies against domoic acid, a causative agent of amnesic shellfish poisoning, three immunogens, domoic acid conjugated with bovine serum albumin (BSA), ovalbumin (OVA) and human gamma globulin (HGG), were prepared [28].
  • Animals pretreated with diazepam (5 mg/kg, ip) tolerated intraventricular dose of domoic acid 0.4 microgram, but showed a loss of pyramidal neurons mainly in the CA3, CA4, and a part of CA1 areas of the dorsal hippocampus [29].
  • Furthermore, though less potent than LPS, a 4-hour treatment with domoic acid (1 mM) yielded a 757% (p < 0.01) increase in MMP-9 release, but had no effect on MMP-2 [30].

Analytical, diagnostic and therapeutic context of C13732


  1. Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels. Teitelbaum, J.S., Zatorre, R.J., Carpenter, S., Gendron, D., Evans, A.C., Gjedde, A., Cashman, N.R. N. Engl. J. Med. (1990) [Pubmed]
  2. An outbreak of toxic encephalopathy caused by eating mussels contaminated with domoic acid. Perl, T.M., Bédard, L., Kosatsky, T., Hockin, J.C., Todd, E.C., Remis, R.S. N. Engl. J. Med. (1990) [Pubmed]
  3. Mortality of sea lions along the central California coast linked to a toxic diatom bloom. Scholin, C.A., Gulland, F., Doucette, G.J., Benson, S., Busman, M., Chavez, F.P., Cordaro, J., DeLong, R., De Vogelaere, A., Harvey, J., Haulena, M., Lefebvre, K., Lipscomb, T., Loscutoff, S., Lowenstine, L.J., Marin, R., Miller, P.E., McLellan, W.A., Moeller, P.D., Powell, C.L., Rowles, T., Silvagni, P., Silver, M., Spraker, T., Trainer, V., Van Dolah, F.M. Nature (2000) [Pubmed]
  4. Domoic acid-induced neuronal damage in the rat hippocampus: changes in apoptosis related genes (bcl-2, bax, caspase-3) and microglial response. Ananth, C., Thameem Dheen, S., Gopalakrishnakone, P., Kaur, C. J. Neurosci. Res. (2001) [Pubmed]
  5. Phosphate energy metabolism during domoic acid-induced seizures. Sutherland, G.R., Ross, B.D., Lesiuk, H., Peeling, J., Pillay, N., Pinsky, C. Epilepsia (1993) [Pubmed]
  6. Neurotoxicity of domoic Acid in cerebellar granule neurons in a genetic model of glutathione deficiency. Giordano, G., White, C.C., McConnachie, L.A., Fernandez, C., Kavanagh, T.J., Costa, L.G. Mol. Pharmacol. (2006) [Pubmed]
  7. Sequelae of parenteral domoic acid administration in rats: comparison of effects on different anatomical markers in brain. Appel, N.M., Rapoport, S.I., O'Callaghan, J.P. Synapse (1997) [Pubmed]
  8. Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid. Scallet, A.C., Schmued, L.C., Johannessen, J.N. Neurotoxicology and teratology. (2005) [Pubmed]
  9. Persisting behavioral consequences of prenatal domoic acid exposure in rats. Levin, E.D., Pizarro, K., Pang, W.G., Harrison, J., Ramsdell, J.S. Neurotoxicology and teratology. (2005) [Pubmed]
  10. Toxicology of mussels contaminated by neuroexcitant domoic acid. Glavin, G., Pinsky, C., Bose, R. Lancet (1989) [Pubmed]
  11. Temporal lobe epilepsy caused by domoic acid intoxication: evidence for glutamate receptor-mediated excitotoxicity in humans. Cendes, F., Andermann, F., Carpenter, S., Zatorre, R.J., Cashman, N.R. Ann. Neurol. (1995) [Pubmed]
  12. Hippocampal changes in developing postnatal mice following intrauterine exposure to domoic acid. Dakshinamurti, K., Sharma, S.K., Sundaram, M., Watanabe, T. J. Neurosci. (1993) [Pubmed]
  13. Comparative behavioural toxicity of domoic acid and kainic acid in neonatal rats. Doucette, T.A., Strain, S.M., Allen, G.V., Ryan, C.L., Tasker, R.A. Neurotoxicology and teratology. (2000) [Pubmed]
  14. Evaluation of cardiac lesions and risk factors associated with myocarditis and dilated cardiomyopathy in southern sea otters (Enhydra lutris nereis). Kreuder, C., Miller, M.A., Lowenstine, L.J., Conrad, P.A., Carpenter, T.E., Jessup, D.A., Mazet, J.A. Am. J. Vet. Res. (2005) [Pubmed]
  15. Domoic acid poisoning and mussel-associated intoxication: preliminary investigations into the response of mice and rats to toxic mussel extract. Iverson, F., Truelove, J., Nera, E., Tryphonas, L., Campbell, J., Lok, E. Food Chem. Toxicol. (1989) [Pubmed]
  16. The neuroprotective effects of virally-derived caspase inhibitors p35 and crmA following a necrotic insult. Roy, M., Sapolsky, R.M. Neurobiol. Dis. (2003) [Pubmed]
  17. Effects of acromelic acid A on the binding of [3H]-kainic acid and [3H]-AMPA to rat brain synaptic plasma membranes. Smith, A.L., McIlhinney, R.A. Br. J. Pharmacol. (1992) [Pubmed]
  18. Acute phase gene expression in mice exposed to the marine neurotoxin domoic acid. Ryan, J.C., Morey, J.S., Ramsdell, J.S., Van Dolah, F.M. Neuroscience (2005) [Pubmed]
  19. Distribution of NADPH-diaphorase and expression of nNOS, N-methyl-D-aspartate receptor (NMDAR1) and non-NMDA glutamate receptor (GlutR2) genes in the neurons of the hippocampus after domoic acid-induced lesions in adult rats. Ananth, C., Dheen, S.T., Gopalakrishnakone, P., Kaur, C. Hippocampus. (2003) [Pubmed]
  20. Localization of AMPA receptors in the hippocampus and cerebellum of the rat using an anti-receptor monoclonal antibody. Hampson, D.R., Huang, X.P., Oberdorfer, M.D., Goh, J.W., Auyeung, A., Wenthold, R.J. Neuroscience (1992) [Pubmed]
  21. Establishing tolerable dungeness crab (Cancer magister) and razor clam (Siliqua patula) domoic acid contaminant levels. Mariën, K. Environ. Health Perspect. (1996) [Pubmed]
  22. Novel kainate derivatives: potent depolarizing actions on spinal motoneurones and dorsal root fibres in newborn rats. Ishida, M., Shinozaki, H. Br. J. Pharmacol. (1991) [Pubmed]
  23. Induction of inducible nitric oxide synthase expression in activated microglia following domoic acid (DA)-induced neurotoxicity in the rat hippocampus. Ananth, C., Gopalakrishnakone, P., Kaur, C. Neurosci. Lett. (2003) [Pubmed]
  24. The functional expression of a pontine pneumotaxic centre in neonatal rats. Fung, M.L., St John, W.M. J. Physiol. (Lond.) (1995) [Pubmed]
  25. Protective role of melatonin in domoic acid-induced neuronal damage in the hippocampus of adult rats. Ananth, C., Gopalakrishnakone, P., Kaur, C. Hippocampus. (2003) [Pubmed]
  26. New fluorimetric method of liquid chromatography for the determination of the neurotoxin domoic acid in seafood and marine phytoplankton. James, K.J., Gillman, M., Lehane, M., Gago-Martinez, A. Journal of chromatography. A. (2000) [Pubmed]
  27. Mediation of ionotropic glutamate receptors in domoic acid-induced striatal dopamine release in rats. Quintela, B.A., Durán, R., Alfonso, M. Eur. J. Pharmacol. (2000) [Pubmed]
  28. Production and characterization of a monoclonal antibody against domoic acid and its application to enzyme immunoassay. Kawatsu, K., Hamano, Y., Noguchi, T. Toxicon (1999) [Pubmed]
  29. Neural and behavioural effects of domoic acid, an amnesic shellfish toxin, in the rat. Nakajima, S., Potvin, J.L. Canadian journal of psychology. (1992) [Pubmed]
  30. Effect of a short-term in vitro exposure to the marine toxin domoic acid on viability, tumor necrosis factor-alpha, matrix metalloproteinase-9 and superoxide anion release by rat neonatal microglia. Mayer, A.M., Hall, M., Fay, M.J., Lamar, P., Pearson, C., Prozialeck, W.C., Lehmann, V.K., Jacobson, P.B., Romanic, A.M., Uz, T., Manev, H. BMC Pharmacol. (2001) [Pubmed]
  31. A kainic acid receptor from frog brain purified using domoic acid affinity chromatography. Hampson, D.R., Wenthold, R.J. J. Biol. Chem. (1988) [Pubmed]
  32. UV resonance Raman detection and quantitation of domoic acid in phytoplankton. Wu, Q., Nelson, W.H., Treubig, J.M., Brown, P.R., Hargraves, P., Kirs, M., Feld, M., Desari, R., Manoharan, R., Hanlon, E.B. Anal. Chem. (2000) [Pubmed]
  33. Analysis of domoic acid and isomers in seafood by capillary electrophoresis. Zhao, J.Y., Thibault, P., Quilliam, M.A. Electrophoresis (1997) [Pubmed]
  34. Preparation and characterization of domoic acid-protein conjugates using small amount of toxin in a reversed micellar medium: application in a competitive enzyme-linked immunosorbent assay. Branaa, P., Naar, J., Chinain, M., Pauillac, S. Bioconjug. Chem. (1999) [Pubmed]
WikiGenes - Universities