Disease relevance of Pyranisamine

• The recombinant form of the cellulase CelF of Clostridium cellulolyticum, tagged by a C-terminal histine tail, was overproduced in Escherichia coli [1].
• On Days 15 and 29, pyrilamine maleate was administered prior to inhalation challenges to block H1 receptors and to allow exposure for 20 min to 63 mg/m3 OA without histamine shock and fatal anaphylactic reactions [2].
• The mutagenic activities of the N-oxide and the N- and O-dealkylated pyrilamine derivatives, and pyrilamine maleate were measured by reversion of Salmonella typhimurium strains TA97, TA98, TA100, and TA102 [3].
• Among the 20 male and 20 female rats treated with pyrilamine maleate mixed into the diet, two males and two females had hepatocellular carcinomas and, in addition, five males and eight females had neoplastic nodules in the liver [4].
• Treatment with the antihistamine drug mepyramine maleate suppresses the cutaneous hypersensitivity reactions [5].

High impact information on Pyranisamine

• Vasopermeabilization activity in the guinea pig without and with H1 antihistamine (pyrilamine maleate) pretreatment was assessed by extrusion of Evans blue dye-treated plasma [6].
• Surprisingly, the greatest difference in enzymatic activities was a marked increase in 17alpha-hydroxylase activity of P450c17 in the baboon, which differs from rhesus only at residue 255 [arginine (Arg) in baboon, histine (His) in rhesus] [7].
• The histamine induced proliferation was mediated through an H2 histamine receptor on the fibroblast, being inhibited by cimetidine, an H2 antagonist, and not by pyrilamine maleate, an antagonist of the H1 receptor [8].
• Administration of pyrilamine maleate, an H1 receptor antagonist, before MAN or hCG injection reduced the number of cysts formed but did not alter ovulation rate [9].
• The Schultz-Dale reaction was only observed in the sensitized pulmonary veins; it could be blocked (25-45%) by pyrilamine maleate (10(-7) M) and (5-15%) by phentolamine (5 X 10(-6) M) [10].

Chemical compound and disease context of Pyranisamine

• The size of the bulla was lessened by mepyramine maleate, whereas levamisole enhanced the response to the extract [11].

Biological context of Pyranisamine

• The higher dose of ACh (10 mg in 0.1 ml of saline), however, produced slight increase of vascular permeability in rabbits, which was inhibited by the antihistamine, pyrilamine maleate [12].
• Passive cutaneous anaphylaxis was produced in chickens pretreated with the antihistamine mepyramine maleate [13].
• By using density gradient centrifugation, DNA repair was detected in hepatocytes following exposure to the antihistamines pyrilamine maleate and tripelennamine HCl [14].
• Histosol: a clearing agent for hard tissue histology and special staining technics [15].

Anatomical context of Pyranisamine

• Urine and feces are the major routes of elimination of pyrilamine maleate in the Fischer 344 rat [16].
• The lymph node response was not inhibited by the antihistamine, mepyramine maleate, but was inhibited by puromycin [17].
• The possibility that the latter may be mediated not only by H2-receptors in the heart and peripheral blood vessels but also by overflow stimulation of H1-receptors was investigated in a double-blind study using impromidine with or without the H1-antagonist, mepyramine maleate [18].
• In the present investigation it is shown that they release histamine from rat mast cells and that their effect on microvascular permeability can be inhibited by previous histamine depletion of the skin or treatment with an antihistamine, the H1-blocker mepyramine maleate [19].
• In addition, cimetidine but not pyrilamine maleate and thioperamide inhibited the histamine-induced angiogenesis in the granulation tissue in HDC-/- mice [20].

Associations of Pyranisamine with other chemical compounds

• IP3 formation was inhibited by H1 receptor antagonists mepyramine maleate and chlorphenyramine, but not by H2 receptor antagonist cimetidine [21].
• Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats [4].
• Thus this study (1) verifies that the unscheduled DNA synthesis seen in the hepatocyte primary culture/DNA repair test after carcinogen exposure in DNA repair And (2) confirms the induction of DNA repair by pyrilamine maleate and tripelennamine HCl but not by methapyrilene [14].
• Catalase (CAT), dimethyl sulfoxide (DMS0), dexamethasone (DM), indomethacin (IM), phenidone (PD), AA-861 (AA), pyrilamine maleate (PY), or cimetidine (CM) was continuously administered to female Balb/c mice using microosmotic pumps for 72 hr and intraperitoneally once before SPFX administration [22].

Gene context of Pyranisamine

• The encoded protein, denoted mE6(1-120)/mE7(1-60), comprises 120 N-terminus amino acids of E6 and 60 N-terminus amino acids of E7 plus a histine tag, was purified on an affinity column, and subsequently characterized by Western blotting [23].

References