Disease relevance of Lyme Neuroborreliosis

• She showed lymphocytic CSF pleocytosis and pronounced intrathecal Borrelia burgdorferi antibody production, indicating active Lyme neuroborreliosis [1].
• Twenty-nine patients, aged 11-79 years (mean, 50 years), with Lyme neuroborreliosis, facial nerve palsy, and meningitis were treated with oral doxycycline (daily dose, 200-400 mg) for 9-17 days in a prospective, nonrandomized study [2].
• This prospective, open-label, non-randomized trial at the University Departments of Infectious Diseases in Ljubljana, Slovenia, and Göteborg, Sweden, was conducted to compare the kinetics of the cerebrospinal fluid (CSF) mononuclear cell count after 10-14 d of ceftriaxone or doxycycline for treatment of Lyme neuroborreliosis [3].
• The presence of antibodies against Ehrlichia in 132 sera from Danish patients with definite Lyme neuroborreliosis were examined in order to provide immunoserologic evidence of this infection in Denmark [4].

High impact information on Lyme Neuroborreliosis

• The polymerase chain reaction in the diagnosis of Lyme neuroborreliosis [5].
• These data support the hypothesis that cytokines such as IL-6 are important amplification molecules for CNS inflammation in Lyme neuroborreliosis [6].
• Lyme neuroborreliosis may cause NPH by interfering with subarachnoid CSF flow [1].
• In conclusion, oral doxycycline is an adequate and cost-effective alternative to IV penicillin for the treatment of Lyme neuroborreliosis [7].
• Comparison of intravenous penicillin G and oral doxycycline for treatment of Lyme neuroborreliosis [7].

Chemical compound and disease context of Lyme Neuroborreliosis

• Patients with Lyme neuroborreliosis may benefit from a 10-day treatment with ceftriaxone or cefotaxime [8].
• Randomized comparison of ceftriaxone and cefotaxime in Lyme neuroborreliosis [8].
• Minocycline versus doxycycline in the treatment of Lyme neuroborreliosis [9].
• Fluorine-18-labeled fluorodeoxyglucose-positron emission tomography studies of acute brainstem Lyme neuroborreliosis [corrected] Case report [10].
• Cerebrospinal fluid and serum neopterin levels in patients with Lyme neuroborreliosis [11].

Anatomical context of Lyme Neuroborreliosis

• Cells secreting antibodies to myelin basic protein in cerebrospinal fluid of patients with Lyme neuroborreliosis [12].
• The T-cell response to the aetiologic pathogen Borrelia (B.) burgdorferi in patients with Lyme neuroborreliosis (LN) and in control patients with other neurological diseases was examined by enumerating B. burgdorferi-reactive T cells secreting interferon-gamma (IFN-gamma) with an ELIspot assay [13].
• Glial fibrillary acidic protein (GFAp), the main protein constituent of the intermediate filaments of astrocytes, was analysed in the cerebrospinal fluid (CSF) of 20 patients with Lyme neuroborreliosis as a marker of the astroglial reaction [14].

Gene context of Lyme Neuroborreliosis

• Zymography showed MMP-9 activity in 26 of 31 (84%) CSF samples from patients with acute stage 2 Lyme neuroborreliosis, but not in 20 controls with non-inflammatory neurological disorders [15].
• Diagnosis of Lyme neuroborreliosis with antibodies to recombinant proteins DbpA, BBK32, and OspC, and VlsE IR6 peptide [16].
• Increased expression of the Th1-inducing cytokines interleukin-12 and interleukin-18 in cerebrospinal fluid but not in sera from patients with Lyme neuroborreliosis [17].
• Detection of a 130-kD matrix metalloproteinase in cerebrospinal fluid from a patient with Lyme neuroborreliosis [18].
• Furthermore, the astroglial reaction seemed to occur early in Lyme neuroborreliosis since CSF-GFAp levels were elevated also in patients with recent (< 3 weeks) onset of disease [14].

Analytical, diagnostic and therapeutic context of Lyme Neuroborreliosis

• Intrathecal antibody synthesis in Lyme neuroborreliosis: use of recombinant p41 and a 14-kDa flagellin fragment in ELISA [19].
• PCR testing in CSF is not suitable for routine application in the diagnosis of Lyme neuroborreliosis [20].

References