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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Leukocyte Rolling

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High impact information on Leukocyte Rolling


Biological context of Leukocyte Rolling


Anatomical context of Leukocyte Rolling

  • Thus, the biphasic inhibitory action of heparin on fMLP-induced firm adhesion could in part be attributed to changes in leukocyte delivery (i.e. blood flow) and rolling leukocyte flux induced by heparin [7].
  • METHODS: Leucocyte rolling, arrest and transendothelial migration were quantified in the cremaster muscle microcirculation of 20-week-old MRL/lpr mice, using intravital microscopy [8].
  • Application of Celecoxib resulted in a significant reduction in the rolling leukocyte fraction as well as in the number of leukocytes adherent to the endothelium (0.25 +/- 0. 1 and 96 +/- 34 cells/mm2 respectively) in comparison to the untreated animals with AiA (0.44 +/- 0.03 and 206 +/- 22 cells/mm2 respectively) [9].

Associations of Leukocyte Rolling with chemical compounds


Gene context of Leukocyte Rolling

  • Rolling leukocyte flux after 120 min was significantly attenuated by SOD plus catalase [14].
  • We found that 30 min after TNF-alpha administration leucocyte rolling was unchanged compared with phosphate-buffered saline (PBS)-treated mice and similar in LFA-1-deficient and wild-type animals [15].
  • Intravital microscopy studies of these mice have indicated that, under conditions of low-dose endotoxaemia, iNOS-derived nitric oxide can inhibit leucocyte rolling and adhesion [16].


  1. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression. Steeber, D.A., Campbell, M.A., Basit, A., Ley, K., Tedder, T.F. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo. Kunkel, E.J., Ley, K. Circ. Res. (1996) [Pubmed]
  3. Mechanisms underlying acute mast cell-induced leukocyte rolling and adhesion in vivo. Gaboury, J.P., Johnston, B., Niu, X.F., Kubes, P. J. Immunol. (1995) [Pubmed]
  4. Heparin attenuates TNF-alpha induced inflammatory response through a CD11b dependent mechanism. Salas, A., Sans, M., Soriano, A., Reverter, J.C., Anderson, D.C., Piqué, J.M., Panés, J. Gut (2000) [Pubmed]
  5. Role of interleukin 8 on leucocyte-endothelial cell adhesion in intestinal inflammation. Arndt, H., Bolanowski, M.A., Granger, D.N. Gut (1996) [Pubmed]
  6. Leukocytes extravasation in acute homocysteinemic rats. Fu, W.Y., Dudman, N.P., Perry, M.A., Wang, X.L. Atherosclerosis (2002) [Pubmed]
  7. Inhibitory effect of locally administered heparin on leukocyte rolling and chemoattractant-induced firm adhesion in rat mesenteric venules in vivo. Xie, X., Thorlacius, H., Raud, J., Hedqvist, P., Lindbom, L. Br. J. Pharmacol. (1997) [Pubmed]
  8. MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-alpha. Marshall, D., Dangerfield, J.P., Bhatia, V.K., Larbi, K.Y., Nourshargh, S., Haskard, D.O. Rheumatology (Oxford, England) (2003) [Pubmed]
  9. The effects of Celecoxib on inflammation and synovial microcirculation in murine antigen-induced arthritis. Gebhard, H.H., Zysk, S.P., Schmitt-Sody, M., Jansson, V., Messmer, K., Veihelmann, A. Clinical and experimental rheumatology. (2005) [Pubmed]
  10. Microvascular mechanisms of histamine-induced potentiation of leukocyte adhesion evoked by chemoattractants. Thorlacius, H., Raud, J., Xie, X., Hedqvist, P., Lindbom, L. Br. J. Pharmacol. (1995) [Pubmed]
  11. Preventive effect of sulphated colominic acid on P-selectin-dependent infiltration of macrophages in experimentally induced crescentic glomerulonephritis. Ogawa, D., Shikata, K., Matsuda, M., Okada, S., Wada, J., Yamaguchi, S., Suzuki, Y., Miyasaka, M., Tojo, S., Makino, H. Clin. Exp. Immunol. (2002) [Pubmed]
  12. Acute hyperglycaemia causes severe disturbances of mesenteric microcirculation in an in vivo rat model. Schäffler, A., Arndt, H., Schölmerich, J., Palitzsch, K. Eur. J. Clin. Invest. (1998) [Pubmed]
  13. Histamine can induce leukocyte rolling in rat mesenteric venules. Ley, K. Am. J. Physiol. (1994) [Pubmed]
  14. Delayed "spontaneous" adhesion of leukocytes to rat mesenteric venules is dependent upon reactive oxidants. Morita, Y., Clemens, M.G., Bulkley, G.B. Shock (1995) [Pubmed]
  15. Lymphocyte function antigen 1 (LFA-1) mediates early tumour necrosis factor alpha-induced leucocyte adhesion in venules. Thorlacius, H., Vollmar, B., Guo, Y., Mak, T.W., Pfreundschuh, M.M., Menger, M.D., Schmits, R. Br. J. Haematol. (2000) [Pubmed]
  16. Role of inducible nitric oxide synthase in the regulation of leucocyte recruitment. Hickey, M.J. Clin. Sci. (2001) [Pubmed]
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