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Gene Review

Icam1  -  intercellular adhesion molecule 1

Rattus norvegicus

Synonyms: CD54, ICAM, ICAM-1, Icam-1, Intercellular adhesion molecule 1
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Disease relevance of Icam1


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High impact information on Icam1


Chemical compound and disease context of Icam1


Biological context of Icam1


Anatomical context of Icam1


Associations of Icam1 with chemical compounds


Physical interactions of Icam1


Regulatory relationships of Icam1


Other interactions of Icam1


Analytical, diagnostic and therapeutic context of Icam1


  1. VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis. Sans, M., Panés, J., Ardite, E., Elizalde, J.I., Arce, Y., Elena, M., Palacín, A., Fernández-Checa, J.C., Anderson, D.C., Lobb, R., Piqué, J.M. Gastroenterology (1999) [Pubmed]
  2. Expression and regulation of adhesion molecules in cardiac cells by cytokines: response to acute hypoxia. Kacimi, R., Karliner, J.S., Koudssi, F., Long, C.S. Circ. Res. (1998) [Pubmed]
  3. ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease. Rijcken, E., Krieglstein, C.F., Anthoni, C., Laukoetter, M.G., Mennigen, R., Spiegel, H.U., Senninger, N., Bennett, C.F., Schuermann, G. Gut (2002) [Pubmed]
  4. Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis. Chen, Y.M., Chien, C.T., Hu-Tsai, M.I., Wu, K.D., Tsai, C.C., Wu, M.S., Tsai, T.J. Kidney Int. (1999) [Pubmed]
  5. Expression of intercellular adhesion molecule-1 on rat cardiac myocytes by monocyte chemoattractant protein-1. Ban, K., Ikeda, U., Takahashi, M., Kanbe, T., Kasahara, T., Shimada, K. Cardiovasc. Res. (1994) [Pubmed]
  6. ICAM-1-induced expression of proinflammatory cytokines in astrocytes: involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. Lee, S.J., Drabik, K., Van Wagoner, N.J., Lee, S., Choi, C., Dong, Y., Benveniste, E.N. J. Immunol. (2000) [Pubmed]
  7. Leukocytes mediate retinal vascular remodeling during development and vaso-obliteration in disease. Ishida, S., Yamashiro, K., Usui, T., Kaji, Y., Ogura, Y., Hida, T., Honda, Y., Oguchi, Y., Adamis, A.P. Nat. Med. (2003) [Pubmed]
  8. A key role for ICAM-1 in generating effector cells mediating inflammatory responses. Camacho, S.A., Heath, W.R., Carbone, F.R., Sarvetnick, N., LeBon, A., Karlsson, L., Peterson, P.A., Webb, S.R. Nat. Immunol. (2001) [Pubmed]
  9. CD48 is a counter-receptor for mouse CD2 and is involved in T cell activation. Kato, K., Koyanagi, M., Okada, H., Takanashi, T., Wong, Y.W., Williams, A.F., Okumura, K., Yagita, H. J. Exp. Med. (1992) [Pubmed]
  10. CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells. Kurose, I., Saito, H., Miura, S., Ebinuma, H., Higuchi, H., Watanabe, N., Zeki, S., Nakamura, T., Takaishi, M., Ishii, H. J. Clin. Invest. (1997) [Pubmed]
  11. Requirement and role of C5a in acute lung inflammatory injury in rats. Mulligan, M.S., Schmid, E., Beck-Schimmer, B., Till, G.O., Friedl, H.P., Brauer, R.B., Hugli, T.E., Miyasaka, M., Warner, R.L., Johnson, K.J., Ward, P.A. J. Clin. Invest. (1996) [Pubmed]
  12. Dexamethasone reduces lung eosinophilia, and VCAM-1 and ICAM-1 expression induced by Sephadex beads in rats. Ito, A., Miyake, M., Morishita, M., Ito, K., Torii, S., Sakamoto, T. Eur. J. Pharmacol. (2003) [Pubmed]
  13. Increased expression of cytokines and adhesion molecules in rat chronic esophagitis. Hamaguchi, M., Fujiwara, Y., Takashima, T., Hayakawa, T., Sasaki, E., Shiba, M., Watanabe, T., Tominaga, K., Oshitani, N., Matsumoto, T., Higuchi, K., Arakawa, T. Digestion (2003) [Pubmed]
  14. Hepatic cold hypoxia and oxidative stress: implications for ICAM-1 expression and modulation by glutathione during experimental isolated liver preservation. El-Wahsh, M., Fuller, B., Davidson, B., Rolles, K. Cryobiology (2003) [Pubmed]
  15. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia/reperfusion injury in a rat model. Ito, H., Nakano, A., Kinoshita, M., Matsumori, A. Lab. Invest. (2003) [Pubmed]
  16. High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-kappa B-dependent. Park, C.W., Kim, J.H., Lee, J.H., Kim, Y.S., Ahn, H.J., Shin, Y.S., Kim, S.Y., Choi, E.J., Chang, Y.S., Bang, B.K., Lee, J.W. Diabetologia (2000) [Pubmed]
  17. Elevation of cyclic AMP levels in astrocytes antagonizes cytokine-induced adhesion molecule expression. Ballestas, M.E., Benveniste, E.N. J. Neurochem. (1997) [Pubmed]
  18. Ischemia-reperfusion injury in renal transplantation is independent of the immunologic background. Dragun, D., Hoff, U., Park, J.K., Qun, Y., Schneider, W., Luft, F.C., Haller, H. Kidney Int. (2000) [Pubmed]
  19. Sequential analysis of adhesion molecules and their ligands in rat renal allografts during the development of chronic rejection. Kauppinen, H., Soots, A., Krogerus, L., Loginov, R., Holma, K., Ahonen, J., Lautenschlager, I. Transpl. Int. (2000) [Pubmed]
  20. Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1. Nadeau, K.C., Azuma, H., Tilney, N.L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  21. Monocyte chemoattractant protein-1 enhances expression of intercellular adhesion molecule-1 following ischemia-reperfusion of the liver in rats. Yamaguchi, Y., Matsumura, F., Takeya, M., Ichiguchi, O., Kuratsu, J.I., Horiuchi, T., Akizuki, E., Matsuda, T., Okabe, K., Ohshiro, H., Liang, J., Mori, K., Yamada, S., Takahashi, K., Ogawa, M. Hepatology (1998) [Pubmed]
  22. Ultrasound derived imaging and quantification of cell adhesion molecules in experimental autoimmune encephalomyelitis (EAE) by Sensitive Particle Acoustic Quantification (SPAQ). Reinhardt, M., Hauff, P., Linker, R.A., Briel, A., Gold, R., Rieckmann, P., Becker, G., Toyka, K.V., Mäurer, M., Schirner, M. Neuroimage (2005) [Pubmed]
  23. ICAM-1-coupled signaling pathways in astrocytes converge to cyclic AMP response element-binding protein phosphorylation and TNF-alpha secretion. Etienne-Manneville, S., Chaverot, N., Strosberg, A.D., Couraud, P.O. J. Immunol. (1999) [Pubmed]
  24. Lymphocyte migration through brain endothelial cell monolayers involves signaling through endothelial ICAM-1 via a rho-dependent pathway. Adamson, P., Etienne, S., Couraud, P.O., Calder, V., Greenwood, J. J. Immunol. (1999) [Pubmed]
  25. The strength of the OVA-induced airway inflammation in rats is strain dependent. Hylkema, M.N., Hoekstra, M.O., Luinge, M., Timens, W. Clin. Exp. Immunol. (2002) [Pubmed]
  26. Angiotensin II stimulates intercellular adhesion molecule-1 via an AT1 receptor/nuclear factor-kappaB pathway in brain microvascular endothelial cells. Liu, H.Q., Wei, X.B., Sun, R., Cai, Y.W., Lou, H.Y., Wang, J.W., Chen, A.F., Zhang, X.M. Life Sci. (2006) [Pubmed]
  27. Intercellular adhesion molecule-1 and CD18 are involved in neutrophil adhesion and its cytotoxicity to cultured sinusoidal endothelial cells in rats. Sakamoto, S., Okanoue, T., Itoh, Y., Sakamoto, K., Nishioji, K., Nakagawa, Y., Yoshida, N., Yoshikawa, T., Kashima, K. Hepatology (1997) [Pubmed]
  28. Interleukin 1-beta- and tumor necrosis factor-alpha-mediated regulation of ICAM-1 gene expression in astrocytes requires protein kinase C activity. Ballestas, M.E., Benveniste, E.N. Glia (1995) [Pubmed]
  29. Effects of the AT1 receptor antagonist on adhesion molecule expression in leukocytes and brain microvessels of stroke-prone spontaneously hypertensive rats. Takemori, K., Ito, H., Suzuki, T. Am. J. Hypertens. (2000) [Pubmed]
  30. Activated rat pancreatic stellate cells express intercellular adhesion molecule-1 (ICAM-1) in vitro. Masamune, A., Sakai, Y., Kikuta, K., Satoh, M., Satoh, A., Shimosegawa, T. Pancreas (2002) [Pubmed]
  31. Decreased expression of intercellular adhesion molecule-1 (ICAM-1) and urokinase-type plasminogen activator receptor (uPAR) is associated with tumor cell spreading in vivo. Donadio, A.C., Remedi, M.M., Frede, S., Bonacci, G.R., Chiabrando, G.A., Pistoresi-Palencia, M.C. Clin. Exp. Metastasis (2002) [Pubmed]
  32. Reversal Effect of Thalidomide on Established Hepatic Cirrhosis in Rats via Inhibition of Nuclear Factor-kappaB/Inhibitor of Nuclear Factor-kappaB Pathway. Lv, P., Luo, H.S., Zhou, X.P., Xiao, Y.J., Paul, S.C., Si, X.M., Zhou, Y.H. Arch. Med. Res. (2007) [Pubmed]
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