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Gene Review

Vcam1  -  vascular cell adhesion molecule 1

Rattus norvegicus

Synonyms: V-CAM 1, VCAM-1, Vascular cell adhesion protein 1, Vcam-1
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Disease relevance of Vcam1


High impact information on Vcam1


Chemical compound and disease context of Vcam1


Biological context of Vcam1


Anatomical context of Vcam1


Associations of Vcam1 with chemical compounds


Physical interactions of Vcam1

  • TNF-alpha also induced the specific interaction of proteins from GMC nuclei with an oligonucleotide bearing the NF-kappa B binding sites in the VCAM-1 promoter [20].

Regulatory relationships of Vcam1

  • However, when added together with interleukin-1beta, angiotensin II, through activation of the AT(1) receptor, inhibited iNOS expression and enhanced VCAM-1 expression induced by the cytokine [16].
  • In addition, expression of E-selectin and ICAM-1 was up regulated in both rat strains whereas expression of VCAM-1 was only up regulated in the BN rat [21].
  • Growth factors, eg, transforming growth factor-beta1, down-regulated I-CAM-1- and V-CAM-1-coding mRNAs and stimulated N-CAM expression of HSC [22].
  • Ang II stimulates mRNA and protein expression of VCAM-1 in these cells via the AT(1) receptor [13].
  • Blocking LFA-or ICAM-1 resulted in a significant reduction in migration across IL-1 beta-activated endothelial cells to 17.4% and 20.9% of control values respectively although blocking the VLA-4/VCAM-1 interaction had no significant effect [23].

Other interactions of Vcam1

  • Expression of the NF-kappa B-regulated genes, vascular cell adhesion molecule (VCAM)-1 and monocyte chemotactic protein (MCP)-1, was apparent in SMCs within 4 hours after injury [15].
  • Progressive increases in ICAM-1, VCAM-1, IL-1beta, and TNF-alpha expression followed at 8 and 12 weeks [24].
  • In contrast, lymphocyte diapedesis is mostly supported through the LFA-1/ICAM-1 pairing, with a small proportion being mediated by VLA-4/VCAM-1 on IL-1 beta-activated EC [25].
  • In contrast, inflammatory cytokines like tumor necrosis factor-alpha reduced N-CAM-coding mRNAs, whereas induction of I-CAM-1- and V-CAM-1-specific transcripts increased several fold [22].
  • RESULTS: Semiquantitative analysis revealed that the capillary density and mRNA expression of PECAM-1, VCAM-1 and VEGF were significantly lower in the one-kidney group compared to the two-kidney group on day 14 [26].

Analytical, diagnostic and therapeutic context of Vcam1


  1. Expression and regulation of adhesion molecules in cardiac cells by cytokines: response to acute hypoxia. Kacimi, R., Karliner, J.S., Koudssi, F., Long, C.S. Circ. Res. (1998) [Pubmed]
  2. Adhesion molecule expression in experimental myositis. Ito, T., Kumamoto, T., Horinouchi, H., Yukishige, K., Sugihara, R., Fujimoto, S., Tsuda, T. Muscle Nerve (2002) [Pubmed]
  3. Ocular expression of vascular cell adhesion molecule (VCAM-1) in 2-butoxyethanol-induced hemolysis and thrombosis in female rats. Nyska, A., Moomaw, C.R., Ezov, N., Shabat, S., Levin-Harrus, T., Nyska, M., Redlich, M., Mittelman, M., Yedgar, S., Foley, J.F. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (2003) [Pubmed]
  4. Differential effects of ACE and AT1 receptor inhibition on chemoattractant and adhesion molecule synthesis. Morrissey, J.J., Klahr, S. Am. J. Physiol. (1998) [Pubmed]
  5. VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis. Sans, M., Panés, J., Ardite, E., Elizalde, J.I., Arce, Y., Elena, M., Palacín, A., Fernández-Checa, J.C., Anderson, D.C., Lobb, R., Piqué, J.M. Gastroenterology (1999) [Pubmed]
  6. Dexamethasone reduces lung eosinophilia, and VCAM-1 and ICAM-1 expression induced by Sephadex beads in rats. Ito, A., Miyake, M., Morishita, M., Ito, K., Torii, S., Sakamoto, T. Eur. J. Pharmacol. (2003) [Pubmed]
  7. Effects of fatty acids on liver metastasis of ACL-15 rat colon cancer cells. Iwamoto, S., Senzaki, H., Kiyozuka, Y., Ogura, E., Takada, H., Hioki, K., Tsubura, A. Nutrition and cancer. (1998) [Pubmed]
  8. C1-inhibitor reduces hepatic leukocyte-endothelial interaction and the expression of VCAM-1 in LPS-induced sepsis in the rat. Croner, R.S., Lehmann, T.G., Fallsehr, C., Herfarth, C., Klar, E., Kirschfink, M. Microvasc. Res. (2004) [Pubmed]
  9. Angiotensin II induces vascular cell adhesion molecule-1 expression in rat vasculature: A potential link between the renin-angiotensin system and atherosclerosis. Tummala, P.E., Chen, X.L., Sundell, C.L., Laursen, J.B., Hammes, C.P., Alexander, R.W., Harrison, D.G., Medford, R.M. Circulation (1999) [Pubmed]
  10. ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease. Rijcken, E., Krieglstein, C.F., Anthoni, C., Laukoetter, M.G., Mennigen, R., Spiegel, H.U., Senninger, N., Bennett, C.F., Schuermann, G. Gut (2002) [Pubmed]
  11. Sequential analysis of adhesion molecules and their ligands in rat renal allografts during the development of chronic rejection. Kauppinen, H., Soots, A., Krogerus, L., Loginov, R., Holma, K., Ahonen, J., Lautenschlager, I. Transpl. Int. (2000) [Pubmed]
  12. Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats. Crews, G.M., Erickson, L., Pan, F., Fisniku, O., Jang, M.S., Wynn, C., Benediktsson, H., Kobayashi, M., Jiang, H. Transplant. Proc. (2005) [Pubmed]
  13. Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress. Pueyo, M.E., Gonzalez, W., Nicoletti, A., Savoie, F., Arnal, J.F., Michel, J.B. Arterioscler. Thromb. Vasc. Biol. (2000) [Pubmed]
  14. Effects of antibody reactivity to major histocompatibility complex (MHC) and non-MHC alloantigens on graft endothelial cells in heart allograft rejection. Derhaag, J.G., Duijvestijn, A.M., Damoiseaux, J.G., van Breda Vriesman, P.J. Transplantation (2000) [Pubmed]
  15. Activation of the NF-kappa B and I kappa B system in smooth muscle cells after rat arterial injury. Induction of vascular cell adhesion molecule-1 and monocyte chemoattractant protein-1. Landry, D.B., Couper, L.L., Bryant, S.R., Lindner, V. Am. J. Pathol. (1997) [Pubmed]
  16. Angiotensin II differentially regulates interleukin-1-beta-inducible NO synthase (iNOS) and vascular cell adhesion molecule-1 (VCAM-1) expression: role of p38 MAPK. Jiang, B., Xu, S., Hou, X., Pimentel, D.R., Cohen, R.A. J. Biol. Chem. (2004) [Pubmed]
  17. Chronic blockade of NO synthase activity induces a proinflammatory phenotype in the arterial wall: prevention by angiotensin II antagonism. Luvarà, G., Pueyo, M.E., Philippe, M., Mandet, C., Savoie, F., Henrion, D., Michel, J.B. Arterioscler. Thromb. Vasc. Biol. (1998) [Pubmed]
  18. Calcium [corrected] channel blockers reduce angiotensin II-induced superoxide generation and inhibit lectin-like oxidized low-density lipoprotein receptor-1 expression in endothelial cells. Toba, H., Shimizu, T., Miki, S., Inoue, R., Yoshimura, A., Tsukamoto, R., Sawai, N., Kobara, M., Nakata, T. Hypertens. Res. (2006) [Pubmed]
  19. Direct evidence of leukocyte adhesion in arterioles by angiotensin II. Alvarez, A., Cerdá-Nicolás, M., Naim Abu Nabah, Y., Mata, M., Issekutz, A.C., Panés, J., Lobb, R.R., Sanz, M.J. Blood (2004) [Pubmed]
  20. Nuclear factor-kappa B mediates induction of vascular cell adhesion molecule-1 in glomerular mesangial cells. Khachigian, L.M., Collins, T., Fries, J.W. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  21. The strength of the OVA-induced airway inflammation in rats is strain dependent. Hylkema, M.N., Hoekstra, M.O., Luinge, M., Timens, W. Clin. Exp. Immunol. (2002) [Pubmed]
  22. Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair. Knittel, T., Dinter, C., Kobold, D., Neubauer, K., Mehde, M., Eichhorst, S., Ramadori, G. Am. J. Pathol. (1999) [Pubmed]
  23. Factors controlling T-cell migration across rat cerebral endothelium in vitro. Pryce, G., Male, D., Campbell, I., Greenwood, J. J. Neuroimmunol. (1997) [Pubmed]
  24. Proinflammatory gene expression and macrophage recruitment in the rat remnant kidney. Taal, M.W., Zandi-Nejad, K., Weening, B., Shahsafaei, A., Kato, S., Lee, K.W., Ziai, F., Jiang, T., Brenner, B.M., MacKenzie, H.S. Kidney Int. (2000) [Pubmed]
  25. Lymphocyte adhesion and transendothelial migration in the central nervous system: the role of LFA-1, ICAM-1, VLA-4 and VCAM-1. off. Greenwood, J., Wang, Y., Calder, V.L. Immunology (1995) [Pubmed]
  26. Impairment of vascular regeneration precedes progressive glomerulosclerosis in anti-Thy 1 glomerulonephritis. Wada, Y., Morioka, T., Oyanagi-Tanaka, Y., Yao, J., Suzuki, Y., Gejyo, F., Arakawa, M., Oite, T. Kidney Int. (2002) [Pubmed]
  27. Role of p38 MAP kinase in postcapillary venule leukocyte adhesion induced by ischemia/reperfusion injury. Johns, D.G., Ao, Z., Willette, R.N., Macphee, C.H., Douglas, S.A. Pharmacol. Res. (2005) [Pubmed]
  28. Rat cytomegalovirus infection in kidney allograft recipients is associated with increased expression of intracellular adhesion molecule-1 vascular adhesion molecule-1, and their ligands leukocyte function antigen-1 and very late antigen-4 in the graft. Kloover, J.S., Soots, A.P., Krogerus, L.A., Kauppinen, H.O., Loginov, R.J., Holma, K.L., Bruggeman, C.A., Ahonen, P.J., Lautenschlager, I.T. Transplantation (2000) [Pubmed]
  29. Early up-regulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression in rats with hemorrhagic shock and resuscitation. Sun, L.L., Ruff, P., Austin, B., Deb, S., Martin, B., Burris, D., Rhee, P. Shock (1999) [Pubmed]
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