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MeSH Review

Delphinium

 
 
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High impact information on Delphinium

  • Methyllycaconitine, a toxin isolated from the seeds of Delphinium brownii, inhibited acetylcholine- and anatoxin-induced whole-cell currents in cultured fetal rat hippocampal neurons, at picomolar concentrations [1].
  • In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum [2].
  • Three new norditerpenoid alkaloids, trifoliolasines A (1), B (3), and C (5), were isolated from the whole plant of Delphinium trifoliolatum FINET et GAGNEP, and their structures were established based on the spectral data [3].
  • Six volatile compounds, ethylmethylbenzene (1), 1-isopentyl-2,4, 5-trimethylbenzene (2), 2-(hex-3-ene-2-one)phenylmethyl ketone (3), E and Z isomers of 3-butylidene-3H-isobenzofuran-1-one (4 and 5), and 2-penten-1-ylbenzoic acid (6), were isolated from the mosquitocidal hexane extract of Delphinium x cultorum cv. Magic Fountains flowers [4].
  • The roots of Delphinium denudatum have yielded a new diterpenoid alkaloid, 8-acetylheterophyllisine (1), in addition to the known alkaloids vilmorrianone (2), panicutine (3), denudatine (4), isotalatizidine (5), and condelphine (6), as well as 3-hydroxy-2-methyl-4H-pyran-4-one (7) [5].
 

Biological context of Delphinium

 

Associations of Delphinium with chemical compounds

 

Gene context of Delphinium

  • These included field stations at Hugo and Woodland Park, Colorado, and Imperial, Nebraska (1905-1909), to study locoweed; Gunnison, Colorado (1910-1912), to primarily study larkspur; and Greycliff, Montana (1912-1915), to study the poisonous plants of the Yellowstone Valley. Dr. Rodney True replaced Mr. Chestnut in 1904 and in 1905 hired Dr. C [10].
  • Dried roots of Delphinium denudatum Wall. are a popular folk remedy for the treatment of epilepsy in the traditional Unani system of medicine in the sub-continent [11].

References

  1. Blockade of nicotinic currents in hippocampal neurons defines methyllycaconitine as a potent and specific receptor antagonist. Alkondon, M., Pereira, E.F., Wonnacott, S., Albuquerque, E.X. Mol. Pharmacol. (1992) [Pubmed]
  2. In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum. Raza, M., Shaheen, F., Choudhary, M.I., Rahman, A.U., Sombati, S., DeLorenzo, R.J. Neurosci. Lett. (2002) [Pubmed]
  3. New C19-diterpenoid alkaloids from Delphinium trifoliolatum. Zhou, X.L., Chen, Q.H., Wang, F.P. Chem. Pharm. Bull. (2004) [Pubmed]
  4. Antifeedant and mosquitocidal compounds from Delphinium x cultorum cv. Magic fountains flowers. Miles, J.E., Ramsewak, R.S., Nair, M.G. J. Agric. Food Chem. (2000) [Pubmed]
  5. Antifungal diterpenoid alkaloids from Delphinium denudatum. Atta-ur-Rahman, n.u.l.l., Nasreen, A., Akhtar, F., Shekhani, M.S., Clardy, J., Parvez, M., Choudhary, M.I. J. Nat. Prod. (1997) [Pubmed]
  6. Co-expression of an ethylene receptor gene, ERS1, and ethylene signaling regulator gene, CTR1, in Delphinium during abscission of florets. Kuroda, S., Hirose, Y., Shiraishi, M., Davies, E., Abe, S. Plant Physiol. Biochem. (2004) [Pubmed]
  7. Adverse influence of social facilitation and learning context in training cattle to avoid eating larkspur. Ralphs, M.H., Olsen, J.D. J. Anim. Sci. (1990) [Pubmed]
  8. Feed aversion induced by intraruminal infusion with larkspur extract in cattle. Olsen, J.D., Ralphs, M.H. Am. J. Vet. Res. (1986) [Pubmed]
  9. Look what I found! Poison hunting on eBay. Cantrell, F.L. Clinical toxicology (Philadelphia, Pa.) (2005) [Pubmed]
  10. History of USDA poisonous plant research. James, L.F. Journal of natural toxins. (1999) [Pubmed]
  11. Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum. Raza, M., Shaheen, F., Choudhary, M.I., Sombati, S., Rafiq, A., Suria, A., Rahman, A., DeLorenzo, R.J. Journal of ethnopharmacology. (2001) [Pubmed]
 
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