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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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High impact information on Hypocrea

  • L-Arabinitol 4-dehydrogenase (EC ) was purified from the filamentous fungus Trichoderma reesei (Hypocrea jecorina) [1].
  • A novel yeast-based method to isolate transcriptional activators was applied to clone regulators binding to the cellulase promoter cbh1 of the filamentous fungus Trichoderma reesei (Hypocrea jecorina) [2].
  • The cellulase system of the filamentous fungus Hypocrea jecorina (Trichoderma reesei) consists of several cellobiohydrolases, endoglucanases, and beta-glucosidases, encoded by separate genes, which are coordinately expressed in the presence of cellulose or the disaccharide sophorose [3].
  • The galactokinase of Hypocrea jecorina is essential for cellulase induction by lactose but dispensable for growth on d-galactose [4].
  • Lactose is the only soluble carbon source which can be used economically for the production of cellulases or heterologous proteins under cellulase expression signals by Hypocrea jecorina (=Trichoderma reesei) [4].

Biological context of Hypocrea


Associations of Hypocrea with chemical compounds


Gene context of Hypocrea

  • To this end, snf1, an ortholog of SNF1, was isolated from the ascomycete Hypocrea jecorina [9].
  • This paper describes the cloning and characterisation of genes for two components of the pathway, ire1 and ptc2, from the filamentous fungus Trichoderma reesei (Hypocrea jecorina) [12].
  • Phylogenetic analysis showed that cytochrome C oxidase subunits III exhibited high degree of similarity to sequences from Hypocrea jecorina, Verticillium lecanii, Podospora anserine, Neurospora crassa and Magnaporthe grisea (99, 90, 84, 82 and 79% identity, respectively) [13].


  1. Cloning and expression of a fungal L-arabinitol 4-dehydrogenase gene. Richard, P., Londesborough, J., Putkonen, M., Kalkkinen, N., Penttilä, M. J. Biol. Chem. (2001) [Pubmed]
  2. ACEII, a novel transcriptional activator involved in regulation of cellulase and xylanase genes of Trichoderma reesei. Aro, N., Saloheimo, A., Ilmén, M., Penttilä, M. J. Biol. Chem. (2001) [Pubmed]
  3. Two adjacent protein binding motifs in the cbh2 (cellobiohydrolase II-encoding) promoter of the fungus Hypocrea jecorina (Trichoderma reesei) cooperate in the induction by cellulose. Zeilinger, S., Mach, R.L., Kubicek, C.P. J. Biol. Chem. (1998) [Pubmed]
  4. The galactokinase of Hypocrea jecorina is essential for cellulase induction by lactose but dispensable for growth on d-galactose. Seiboth, B., Hartl, L., Pail, M., Fekete, E., Karaffa, L., Kubicek, C.P. Mol. Microbiol. (2004) [Pubmed]
  5. Nucleosome transactions on the Hypocrea jecorina (Trichoderma reesei) cellulase promoter cbh2 associated with cellulase induction. Zeilinger, S., Schmoll, M., Pail, M., Mach, R.L., Kubicek, C.P. Mol. Genet. Genomics (2003) [Pubmed]
  6. A complete survey of Trichoderma chitinases reveals three distinct subgroups of family 18 chitinases. Seidl, V., Huemer, B., Seiboth, B., Kubicek, C.P. FEBS J. (2005) [Pubmed]
  7. Identification in the mold Hypocrea jecorina of the first fungal D-galacturonic acid reductase. Kuorelahti, S., Kalkkinen, N., Penttilä, M., Londesborough, J., Richard, P. Biochemistry (2005) [Pubmed]
  8. The Hypocrea jecorina gal10 (uridine 5'-diphosphate-glucose 4-epimerase-encoding) gene differs from yeast homologues in structure, genomic organization and expression. Seiboth, B., Karaffa, L., Sándor, E., Kubicek, C. Gene (2002) [Pubmed]
  9. The Snf1 kinase of the filamentous fungus Hypocrea jecorina phosphorylates regulation-relevant serine residues in the yeast carbon catabolite repressor Mig1 but not in the filamentous fungal counterpart Cre1. Cziferszky, A., Seiboth, B., Kubicek, C.P. Fungal Genet. Biol. (2003) [Pubmed]
  10. D-xylose metabolism in Hypocrea jecorina: loss of the xylitol dehydrogenase step can be partially compensated for by lad1-encoded L-arabinitol-4-dehydrogenase. Seiboth, B., Hartl, L., Pail, M., Kubicek, C.P. Eukaryotic Cell (2003) [Pubmed]
  11. Lactose metabolism and cellulase production in Hypocrea jecorina: the gal7 gene, encoding galactose-1-phosphate uridylyltransferase, is essential for growth on galactose but not for cellulase induction. Seiboth, B., Hofmann, G., Kubicek, C.P. Mol. Genet. Genomics (2002) [Pubmed]
  12. The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei. Valkonen, M., Penttilä, M., Saloheimo, M. Mol. Genet. Genomics (2004) [Pubmed]
  13. Cloning and sequence analysis of a mitochondrial gene cluster encoding cytochrome C oxidase subunit III from Trichoderma pseudokoningii. Wang, T.H., Wu, Z.H., Liu, S.L., Huang, W. DNA Seq. (2002) [Pubmed]
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