Disease relevance of Panthera

• Association and transmission analyses revealed that a 2 bp deletion in the ASIP gene specifies black coloration in domestic cats, and two different "in-frame" deletions in the MC1R gene are implicated in melanism in jaguars and jaguarundis [1].
• Species-specific strains of FIV have been described for domestic cat (Felis catus), puma (Puma concolor), lion (Panthera leo), leopard (Panthera pardus), and Pallas' cat (Otocolobus manul) [2].
• Generalized amyloidosis with predominant renal medullary amyloid deposition was found in four closely related Siberian tigers (Panthera tigris altaica) suffering from end stage kidney diseases [3].
• Preductal aortic coarctation and patent ductus arteriosus in a Sumatran tiger (Panthera tigris sumatrae) cub [4].
• Paresis secondary to an extradural hematoma in a Sumatran tiger (Panthera tigris sumatrae) [5].

High impact information on Panthera

• The Panthera genus numt differs from the numt previously described in the Felis genus in: (1) chromosomal location (F2-telomeric region vs. D2-centromeric region), (2) gene make up (from the ND5 to the ATP8 vs. from the CR to the COII), (3) size (12.5 vs. 7.9 kb), and (4) structure (single monomer vs. tandemly repeated in Felis) [6].
• Viral DNA was amplified, and subsequently analysed, from faeces or formalin-fixed small intestines from an orphaned bat-eared fox (Otocyon megalotis), a free-ranging honey badger (Mellivora capensis), six captive cheetahs (Acinonyx jubatus), a captive Siberian tiger (Panthera tigris altaica) and a free-ranging African wild cat (Felis lybica) [7].
• Seasonal analysis of 1239 captive births of Siberian tigers (Panthera tigris altaica) indicated a peak in April to June (P less than 0.001) [8].
• The inability of the lion, Panthera leo, L. to desaturate linoleic acid [9].
• Monophyly of Panthera genus in pantherine lineage was confirmed and interspecific affinities within this genus revealed a novel branching pattern, with P. tigris diverging first in Panthera genus, followed by P. onca, P. leo, and last two sister species P. pardus and P. uncia [10].

Biological context of Panthera

• The effect of elevated progesterone levels on intraocular pressure in lions (Panthera leo) [11].
• Carnivora: the amino-acid sequence of the adult Sumatran tiger (Panthera tigris sumatrae) hemoglobins [12].

Anatomical context of Panthera

• Double aortic arch and persistent left vena cava in a white lion cub (Panthera leo) [13].

Associations of Panthera with chemical compounds

• Serum concentrations of oestradiol and progesterone during the normal oestrous cycle and early pregnancy in the lion (Panthera leo) [14].
• Serum concentrations of oestradiol and progesterone, and sexual behaviour during the normal oestrous cycle in the leopard (Panthera pardus) [15].
• Use of mibolerone in wolves and in three Panthera species [16].
• The aims of this study were to evaluate the effects of a ketamine/propofol anaesthetic protocol in lions (Panthera leo), and to compare it to two commonly used anaesthetic protocols [17].
• Five male and five female cheetahs and one male Sumatran tiger (Panthera tigris) were studied [18].

Gene context of Panthera

• Generalized AA-amyloidosis in Siberian tigers (Panthera tigris altaica) with predominant renal medullary amyloid deposition [3].
• This study determined whether this was the case for 2 captive jaguars housed at the Woodland Park Zoo, Seattle, WA [19].
• Nutritional secondary hyperparathyroidism in a white lion cub (Panthera leo), with concomitant radiographic double cortical line [20].
• Echinococcosis has been diagnosed in the following wild species in the Kruger National Park : lion, Panthera leo, spotted hyena, Crocuta crocuta, Cape hunting dog, Lycaon pictus, Burchell's zebra, Equus burchelli antiquorum, buffalo, Syncerus caffer, hippopotamus, Hippopotamus amphibius, and impala, Aepyceros melampus [21].

Analytical, diagnostic and therapeutic context of Panthera

• Immobilization of free-ranging African lions (Panthera leo) with a combination of xylazine hydrochloride and ketamine hydrochloride [22].

References