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MeSH Review

Metabolic Detoxication, Phase II

 
 
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Disease relevance of Metabolic Detoxication, Phase II

 

High impact information on Metabolic Detoxication, Phase II

  • During postembryonic stages, SKN-1 regulates a key Phase II detoxification gene through constitutive and stress-inducible mechanisms in the ASI chemosensory neurons and intestine, respectively [5].
  • The widespread expression of MRP in tissues, combined with its ability to transport both lipophilic xenobiotics and the products of phase II detoxification, indicates that the transporter represents a widespread and remarkably versatile cellular defense mechanism [6].
  • Nrf2 is a transcription factor that regulates important antioxidant and phase II detoxification genes [7].
  • A major protective mechanism against oxidizing substances capable of damaging DNA integrity and initiating carcinogenesis is the induction of phase II detoxification and antioxidant enzymes by chemopreventive agents [8].
  • An imbalance between phase I drug metabolism [e.g., cytochrome P450 (CYP)] and phase II detoxification [e.g., glutathione S-transferase (GST)] may contribute to the development of these diseases [9].
 

Biological context of Metabolic Detoxication, Phase II

 

Anatomical context of Metabolic Detoxication, Phase II

 

Associations of Metabolic Detoxication, Phase II with chemical compounds

 

Gene context of Metabolic Detoxication, Phase II

References

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