The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SULT1A2  -  sulfotransferase family, cytosolic, 1A,...

Homo sapiens

Synonyms: Aryl sulfotransferase 2, HAST4, P-PST, P-PST 2, Phenol sulfotransferase 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SULT1A2


Psychiatry related information on SULT1A2


High impact information on SULT1A2


Biological context of SULT1A2

  • Here we report on the sequencing and genomic organization of the STP1 and STP2 genes from a single cosmid clone obtained from chromosome 16p12.1-p11 [7].
  • Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16 [7].
  • The two most closely related genes, STP1 and STP2, encoding P-PST isozymes have been mapped to a single cosmid clone and are, therefore, in close proximity to one another [8].
  • The genes for SULT1A1 and SULT1A2 contain common genetic polymorphisms that are associated with individual variations in levels of enzyme activity as well as variations in biochemical and physical properties [9].
  • Ethnic variation in allele frequencies was also observed for SULT1A2, with frequencies in Caucasian subjects for SULT1A2*1, *2 and *3 of 0.507, 0.389 and 0.104; frequencies in Chinese of 0.924 and 0.076 with no *3 alleles observed; and, finally, in African-Americans frequencies of 0.637, 0.249 and 0.114, respectively [9].

Anatomical context of SULT1A2


Associations of SULT1A2 with chemical compounds


Other interactions of SULT1A2

  • The characterization of the STP2 gene provides further insight into the organization, regulation, and multiplicity of the sulfotransferase supergene family [15].
  • Finally, use of the long polymerase chain reaction made it possible to determine that STP1 is located approximately 45 kb 5'-upstream from STP2 on the short arm of human chromosome 16 [16].
  • While the increased expression of SULT1C1 in malignant tissue seems to reflect tumor dedifferentiation, our finding of unspliced SULT1A2 mRNA in non-malignant tissue offers additional aspects regarding the search for breast cancer risk factors [17].

Analytical, diagnostic and therapeutic context of SULT1A2


  1. Sulfotransferase 1A2*2 is a risk factor for early-onset breast cancer. Hou, M.F., Chen, S.T., Chen, J.C., Yeh, K.T., Lee, T.P., Chen, C.M., Shih, M.C., Lin, C.C., Chang, J.G. Int. J. Mol. Med. (2002) [Pubmed]
  2. Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancer. Moreno, V., Glatt, H., Guino, E., Fisher, E., Meinl, W., Navarro, M., Badosa, J.M., Boeing, H. Int. J. Cancer (2005) [Pubmed]
  3. Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium. Meinl, W., Meerman, J.H., Glatt, H. Pharmacogenetics (2002) [Pubmed]
  4. Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations. Raftogianis, R.B., Wood, T.C., Weinshilboum, R.M. Biochem. Pharmacol. (1999) [Pubmed]
  5. Pharmacogenetics of sulfotransferase. Nagata, K., Yamazoe, Y. Annu. Rev. Pharmacol. Toxicol. (2000) [Pubmed]
  6. Drug-induced down-regulation of topoisomerase I in human epidermoid cancer cells resistant to saintopin and camptothecins. Taniguchi, K., Kohno, K., Kawanami, K., Wada, M., Kanematsu, T., Kuwano, M. Cancer Res. (1996) [Pubmed]
  7. Genomic organization and DNA sequences of two human phenol sulfotransferase genes (STP1 and STP2) on the short arm of chromosome 16. Dooley, T.P., Huang, Z. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  8. Cloning of the human phenol sulfotransferase gene family: three genes implicated in the metabolism of catecholamines, thyroid hormones and drugs. Dooley, T.P. Chem. Biol. Interact. (1998) [Pubmed]
  9. Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects. Carlini, E.J., Raftogianis, R.B., Wood, T.C., Jin, F., Zheng, W., Rebbeck, T.R., Weinshilboum, R.M. Pharmacogenetics (2001) [Pubmed]
  10. cDNA cloning and expression of a new form of human aryl sulfotransferase. Zhu, X., Veronese, M.E., Iocco, P., McManus, M.E. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  11. Human phenol sulfotransferase STP2 gene: molecular cloning, structural characterization, and chromosomal localization. Her, C., Raftogianis, R., Weinshilboum, R.M. Genomics (1996) [Pubmed]
  12. Examination of human tissue cytosols for expression of sulfotransferase isoform 1A2 (SULT1A2) using a SULT1A2-specific antibody. Nowell, S., Green, B., Tang, Y.M., Wiese, R., Kadlubar, F.F. Mol. Pharmacol. (2005) [Pubmed]
  13. Molecular biology of the human phenol sulfotransferase gene family. Dooley, T.P. J. Exp. Zool. (1998) [Pubmed]
  14. Catecholestrogen sulfation: possible role in carcinogenesis. Adjei, A.A., Weinshilboum, R.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  15. Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene. Gaedigk, A., Beatty, B.G., Grant, D.M. Genomics (1997) [Pubmed]
  16. Human phenol sulfotransferase pharmacogenetics: STP1 gene cloning and structural characterization. Raftogianis, R.B., Her, C., Weinshilboum, R.M. Pharmacogenetics (1996) [Pubmed]
  17. Altered expression of the hormone- and xenobiotic-metabolizing sulfotransferase enzymes 1A2 and 1C1 in malignant breast tissue. Aust, S., Obrist, P., Klimpfinger, M., Tucek, G., Jäger, W., Thalhammer, T. Int. J. Oncol. (2005) [Pubmed]
  18. Purification and characterization of human liver phenol-sulfating phenol sulfotransferase. Falany, C.N., Vazquez, M.E., Heroux, J.A., Roth, J.A. Arch. Biochem. Biophys. (1990) [Pubmed]
WikiGenes - Universities