Disease relevance of Mucocele

• Sinus mucocele is rare in the paediatric age, and so far no prevalence data have been reported in children with Cystic Fibrosis (CF) [1].

High impact information on Mucocele

• On the basis of these results, the authors conclude that the use of gadopentetate dimeglumine for contrast enhancement at MR imaging is useful for differentiating mucoceles from neoplasms in the sinonasal tract [2].
• Six cases demonstrated co-existing neoplasm and mucocele: Gadolinium-enhanced MR enabled correct differentiation of five of these lesions, while unenhanced MR enabled correct differentiation of three [2].
• Intracranial mucoceles with midline fusion defects [3].
• Mucoceles of the appendix are a rare group of lesions thought to occur as a sequelae of luminal obstruction as well as certain benign and malignant neoplasms of the appendix [4].
• In accordance with the proposed traumatic origin of extravasation mucocele, histological changes were classified on the basis of mucin extravasation and cyst formation [5].

Chemical compound and disease context of Mucocele

• Voluminous frontoethmoidal mucocele with epidural involvement. Surgical treatment by coronal approach [6].
• Mucosal preservation in the treatment of mucocele with CO2 laser [7].
• A case of thallium-201 accumulation by mucocele [8].
• Multiple oral mucoceles treated with gamma-linolenic acid: report of a case [9].
• Local steroid therapy for oral mucoceles [10].

Anatomical context of Mucocele

• A newborn infant with bilateral mucoceles of the lacrimal sacs also had submucosal masses along the floor of the nose beneath the inferior turbinates communicating with the mucoceles [11].
• In group C, true mucoceles had an intact hyperplastic mucosa, a mucin-filled lumen, and minimal inflammation [12].
• Since TNF-alpha stimulates the production of MMPs from cells such as fibroblasts, these results suggest that TNF-alpha is one of the causal molecules that enhance the accumulation of proteolytic enzymes in luminal fluid of mucoceles [13].
• MELP has a useful place in the management of mucoceles with a significant bony partition from an adjacent sinus or nasal cavity [14].
• CONCLUSIONS: This study demonstrated that ductal and acinar cells of the normal submandibular gland and of labial minor salivary glands adjacent to mucoceles are the major sites of TGF-alpha synthesis and secretion [15].

Gene context of Mucocele

• SUBJECTS AND METHODS: Five MSG tissue sections from SS and seven from mucocele patients were stained immunohistochemically using antibody to IGF-1 receptor and insulin receptor in a horse radish peroxidase and DAB system [16].
• Significant correlation between matrix metalloproteinase activity and tumor necrosis factor-alpha in salivary extravasation mucoceles [13].
• Carcinoembryonic antigen elevation due to bowel sequestration with mucocele formation following colonic resection [17].
• We report a case of bowel sequestration with mucocele formation at the site of previous colo-colic anastomosis causing a mild elevation in CEA [17].
• We examined the content of type IV collagenases and plasminogen activators (PAs) in luminal fluid of four extravasation mucoceles by means of gelatin or casein zymography [18].

References