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MeSH Review

Neural Inhibition

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Disease relevance of Neural Inhibition


High impact information on Neural Inhibition


Biological context of Neural Inhibition

  • GABA and its agonists, as well as benzodiazepines and barbiturates, induce neural inhibition as a consequence of their interaction with specific binding sites for each of these classes of neuroactive substances on the GABA receptor complex of postsynaptic neurons [8].

Anatomical context of Neural Inhibition


Associations of Neural Inhibition with chemical compounds


Gene context of Neural Inhibition

  • The data suggest that failure of neural inhibition induced by FG-7142 engages NMDA receptor processes to produce lasting potentiation of transmission in neural circuits that mediate defensive response with behavioral consequences [16].
  • The results were interpreted in terms of the interaction between arousal and task demands and a neural inhibition model of the P300 was discussed [17].
  • It has been suggested that liver failure leads to the accumulation of substances that bind to a receptor-complex in the brain resulting in neural inhibition which may progress to coma [18].


  1. Enzymes of cerebral GABA metabolism and synaptosomal GABA uptake in acute liver failure in the rabbit: evidence for decreased cerebral GABA-transaminase activity. Ferenci, P., Jacobs, R., Pappas, S.C., Schafer, D.F., Jones, E.A. J. Neurochem. (1984) [Pubmed]
  2. Flumazenil in the treatment of portal systemic encephalopathy--an overview. Gyr, K., Meier, R. Intensive care medicine. (1991) [Pubmed]
  3. Enteric inhibitory neural regulation of human colonic circular muscle: role of nitric oxide. Keef, K.D., Du, C., Ward, S.M., McGregor, B., Sanders, K.M. Gastroenterology (1993) [Pubmed]
  4. Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4. Suzuki, A., Ueno, N., Hemmati-Brivanlou, A. Development (1997) [Pubmed]
  5. Ionic mechanism of the efferent olivo-cochlear inhibition studied by cochlear perfusion in the cat. Desmedt, J.E., Robertson, D. J. Physiol. (Lond.) (1975) [Pubmed]
  6. Neural inhibition by c-Jun as a synergizing factor in bone morphogenetic protein 4 signaling. Peng, Y., Xu, R.H., Mei, J.M., Li, X.P., Yan, D., Kung, H.F., Phang, J.M. Neuroscience (2002) [Pubmed]
  7. Nitric oxide affects mammalian distal colonic smooth muscle by tonic neural inhibition. Middleton, S.J., Cuthbert, A.W., Shorthouse, M., Hunter, J.O. Br. J. Pharmacol. (1993) [Pubmed]
  8. The GABA hypothesis of the pathogenesis of hepatic encephalopathy: current status. Jones, E.A., Schafer, D.F., Ferenci, P., Pappas, S.C. The Yale journal of biology and medicine. (1984) [Pubmed]
  9. Evidence that endogenous thyrotropin-releasing hormone (TRH) may control vagal efferents to thyroid gland: neural inhibition by central administration of TRH antiserum. Tonoue, T., Somiya, H., Matsumoto, H., Ogawa, N., Leppäluoto, J. Regul. Pept. (1982) [Pubmed]
  10. Transcriptional regulation of Zic3 by heterodimeric AP-1(c-Jun/c-Fos) during Xenopus development. Lee, S.Y., Lee, H.S., Moon, J.S., Kim, J.I., Park, J.B., Lee, J.Y., Park, M.J., Kim, J. Exp. Mol. Med. (2004) [Pubmed]
  11. Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area. Givens, B.S., Breese, G.R. J. Pharmacol. Exp. Ther. (1990) [Pubmed]
  12. Decreased potassium-stimulated release of [3H]D-aspartate from hippocampal slices distinguishes encephalopathy related to acute liver failure from that induced by simple hyperammonemia. Hilgier, W., Haugvicova, R., Albrecht, J. Brain Res. (1991) [Pubmed]
  13. Effect of nedocromil sodium on non-adrenergic, non-cholinergic neural responses in guinea pig bronchi in vitro. Lindén, A., Bergendal, A., Lötvall, J., Skoogh, B.E., Löfdahl, C.G. Regul. Pept. (1999) [Pubmed]
  14. Hypovolaemia inhibits acid-induced alkaline transport in the rat duodenum via an alpha-2 adrenergic mechanism. Jönson, C., Hamlet, A., Fändriks, L. Acta Physiol. Scand. (1991) [Pubmed]
  15. Key neuroprotective role for endogenous adenosine A1 receptor activation during asphyxia in the fetal sheep. Hunter, C.J., Bennet, L., Power, G.G., Roelfsema, V., Blood, A.B., Quaedackers, J.S., George, S., Guan, J., Gunn, A.J. Stroke (2003) [Pubmed]
  16. Modelling anxiety disorders following chemical exposures. Adamec, R. Toxicology and industrial health. (1994) [Pubmed]
  17. Effects of preparatory set and task demands on auditory event-related potentials. Nash, A.J., Williams, C.S. Biological psychology. (1982) [Pubmed]
  18. Benzodiazepine receptor antagonists for acute and chronic hepatic encephalopathy. Als-Nielsen, B., Kjaergard, L.L., Gluud, C. Cochrane database of systematic reviews (Online) (2001) [Pubmed]
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