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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Exertion

 
 
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Disease relevance of Exertion

 

High impact information on Exertion

  • Physical effort approximately doubled the plasma levels of adrenaline and noradrenaline in patients as well as in controls [4].
  • OBJECTIVES: This study investigated the involvement of serotonin and dopamine in two cost-benefit paradigms, one in which the cost was delay and the other in which it was physical effort [5].
  • Our results showed a hormonal response to competition, which was especially characterized by an anticipatory rise of T and C. Depending on outcome, significant higher C levels were found in winners in comparison to losers through all the competition but not in T or PRL, both groups expending a similar physical effort [6].
  • Efficient utilization of fatty acids to sustain prolonged physical efforts is thought to be dependent on the carnitine shuttle of muscle [7].
  • Pilocarpine produced only little sweating, and external heat and physical effort were associated with elevation of body temperature [8].
 

Biological context of Exertion

 

Anatomical context of Exertion

  • The results of this study suggest that entacapone does not change the work capacity, work efficiency or respiratory muscle strength in l-dopa treated PD patients with mild to moderate disease severity, and that its use with l-dopa seems to be safe in conditions of maximal physical effort [10].
  • Preliminary study of the relationship between plasma and erythrocyte magnesium variations and some circulating pro-oxidant and antioxidant indices in a standardized physical effort [11].
 

Associations of Exertion with chemical compounds

  • The second experiment examined the effects of O2 on food-deprived rats performing a response (nose poking) that required minimal physical effort to produce deliveries of food pellets [12].
  • In a temperature-gradient test paradigm (requiring less physical effort on the part of the subjects) alpha-flupenthixol did not alter the animals' preferred environmental temperature, nor did it disrupt behavioral thermoregulatory ability [13].
  • The effect of thyroxine treatment on the liver glycogen content both at rest and following physical effort was also studied [14].
  • ACE inhibitor administration does not modify the physical performance of nonathletic subjects; AII is significantly increased with exercise despite captopril treatment; ACE inhibitor decreases GFR significantly but does not influence MA with prolonged physical effort [15].
  • The absence of nandrolone metabolites in sedentary subjects supports the hypothesis that the presence of 19-NA and 19-NE could be linked to physical effort even though the origin is not yet clear [16].
 

Gene context of Exertion

  • Furthermore, high production of IFN and TNF may be associated with extensive physical effort [17].
  • Changes in SHBG concentrations indicated that they were dependent on the conditions of the physical effort and could be related not only to the concentrations of androgens but also to the reduction in body mass [18].
  • We devised a self-administered daily log (the NIH Activity Record, ACTRE), for persons with rheumatoid arthritis (RA), which recorded specific daily activities over a 24-hour period and identified the level of physical effort for each task [19].
  • Beta2 power was reduced after physical effort, which may reflect a decrease in active cognitive processing [20].
  • Work capacity during exercise is positively influenced by preload increase in ATE, while increased afterload due to isometric training in ATS determines higher systemic resistance during physical effort [21].

References

  1. Relevance of delayed hospital admission on development of cardiac rupture during acute myocardial infarction: study in 225 patients with free wall, septal or papillary muscle rupture. Figueras, J., Cortadellas, J., Calvo, F., Soler-Soler, J. J. Am. Coll. Cardiol. (1998) [Pubmed]
  2. Daytime serum myoglobin fluctuations in Steinert's disease. Sabriá-Leal, M., Paret-Masana, A., Montaner-Gomis, I., Gimeno-Leal, J.M., Rey-Joly Barroso, C. Eur. Neurol. (1989) [Pubmed]
  3. Quantitative effect of theophylline anhydrous on exercise-induced asthma after maximal physical effort. Chryssanthopoulos, C., Bruns, W.T., Maksud, M.G., Gallen, W.J., Hause, L.L. Annals of allergy. (1979) [Pubmed]
  4. Exercise-induced platelet aggregation in angina and its possible prevention by beta 1-selective blockade. Winther, K., Rein, E. Eur. Heart J. (1990) [Pubmed]
  5. Differential involvement of serotonin and dopamine systems in cost-benefit decisions about delay or effort. Denk, F., Walton, M.E., Jennings, K.A., Sharp, T., Rushworth, M.F., Bannerman, D.M. Psychopharmacology (Berl.) (2005) [Pubmed]
  6. Effects of competition and its outcome on serum testosterone, cortisol and prolactin. Suay, F., Salvador, A., González-Bono, E., Sanchís, C., Martínez, M., Martínez-Sanchis, S., Simón, V.M., Montoro, J.B. Psychoneuroendocrinology (1999) [Pubmed]
  7. Carnitine in muscle, serum, and urine of nonprofessional athletes: effects of physical exercise, training, and L-carnitine administration. Arenas, J., Ricoy, J.R., Encinas, A.R., Pola, P., D'Iddio, S., Zeviani, M., Didonato, S., Corsi, M. Muscle Nerve (1991) [Pubmed]
  8. Familial simple hypohidrosis with abnormal palmar dermal ridges. Frydman, M., Cohen, H.A., Kauschansky, A., Matoth, Y. Am. J. Med. Genet. (1988) [Pubmed]
  9. Differential effects of timolol and metoprolol on platelet function at rest and during exercise. Winther, K., Knudsen, J.B., Jørgensen, E.O., Eldrup, E. Eur. J. Clin. Pharmacol. (1988) [Pubmed]
  10. The effect of COMT inhibition with entacapone on cardiorespiratory responses to exercise in patients with Parkinson's disease. Lyytinen, J., Kaakkola, S., Gordin, A., Kultalahti, E.R., Teräväinen, H., Sovijärvi, A. Parkinsonism Relat. Disord. (2002) [Pubmed]
  11. Preliminary study of the relationship between plasma and erythrocyte magnesium variations and some circulating pro-oxidant and antioxidant indices in a standardized physical effort. Laires, M.J., Madeira, F., Sérgio, J., Colaço, C., Vaz, C., Felisberto, G.M., Neto, I., Breitenfeld, L., Bicho, M., Manso, C. Magnesium research : official organ of the International Society for the Development of Research on Magnesium. (1993) [Pubmed]
  12. Determinants of behavioral response with ozone exposure. Tepper, J.S., Weiss, B. J. Appl. Physiol. (1986) [Pubmed]
  13. Neuroleptic-induced deficits in operant responding for temperature reinforcement. Ettenberg, A., Carlisle, H.J. Pharmacol. Biochem. Behav. (1985) [Pubmed]
  14. Low muscle and liver glycogen contents in dogs treated with thyroid hormones. Brzezińska, Z., Kaciuba-Uścilko, H. Horm. Metab. Res. (1979) [Pubmed]
  15. Angiotensin-converting enzyme inhibition does not suppress plasma angiotensin II increase during exercise in humans. Aldigier, J.C., Huang, H., Dalmay, F., Lartigue, M., Baussant, T., Chassain, A.P., Leroux-Robert, C., Galen, F.X. J. Cardiovasc. Pharmacol. (1993) [Pubmed]
  16. Testing for nandrolone metabolites in urine samples of professional athletes and sedentary subjects by GC/MS/MS analysis. Gambelunghe, C., Sommavilla, M., Rossi, R. Biomed. Chromatogr. (2002) [Pubmed]
  17. Development and disappearance of tolerance to induction of interferon and tumor necrosis factor response in athletes treated with natural immunostimulant. Inglot, A.D., Sobiech, K.A., Zielińska-Jenczylik, J., Sypuła, A., Majda, J., Lorenc, M. Arch. Immunol. Ther. Exp. (Warsz.) (1999) [Pubmed]
  18. Changes in sex hormone binding globulin, high density lipoprotein cholesterol and plasma lipids in male cyclists during training and competition. Caballero, M.J., Mena, P., Maynar, M. European journal of applied physiology and occupational physiology. (1992) [Pubmed]
  19. Validation of the NIH activity record: a quantitative measure of life activities. Gerber, L.H., Furst, G.P. Arthritis care and research : the official journal of the Arthritis Health Professions Association. (1992) [Pubmed]
  20. Mental and physical effort affect vigilance differently. Smit, A.S., Eling, P.A., Hopman, M.T., Coenen, A.M. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. (2005) [Pubmed]
  21. Association between left ventricular structure and cardiac performance during effort in two morphological forms of athlete's heart. D'Andrea, A., Limongelli, G., Caso, P., Sarubbi, B., Della Pietra, A., Brancaccio, P., Cice, G., Scherillo, M., Limongelli, F., Calabrò, R. International journal of cardiology. (2002) [Pubmed]
 
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