Gene Review:
TNNI3 - troponin I type 3 (cardiac)
Homo sapiens
Synonyms:
CMD1FF, CMD2A, CMH7, Cardiac troponin I, RCM1, ...
Mogensen,
Kruse,
Børglum,
Soker,
Kervancioglu,
Takahashi-Yanaga,
Morimoto,
Harada,
Minakami,
Shiraishi,
Ohta,
Lu,
Sasaguri,
Ohtsuki,
Morrow,
de Lemos,
Sabatine,
Murphy,
Demopoulos,
DiBattiste,
McCabe,
Gibson,
Cannon,
Braunwald,
Kobayashi,
Dong,
Burkart,
Cheung,
Solaro,
Mogensen,
Murphy,
Kubo,
Bahl,
Moon,
Klausen,
Elliott,
McKenna,
Kruger,
Zittrich,
Redwood,
Blaudeck,
James,
Robbins,
Pfitzer,
Stehle,
Eigel,
van Ingen,
Wagenpfeil,
Ishii,
Nomura,
Okuma,
Minagawa,
Naruse,
Mori,
Ishikawa,
Kurokawa,
Hirano,
Kondo,
Nagamura,
Ezaki,
Hishida,
Gerhardt,
Nordin,
Herbert,
Burzell,
Isaksson,
Gustavsson,
Haglund,
Müller-Bardorff,
Katus,
- Frequency and clinical expression of cardiac troponin I mutations in 748 consecutive families with hypertrophic cardiomyopathy. Mogensen, J., Murphy, R.T., Kubo, T., Bahl, A., Moon, J.C., Klausen, I.C., Elliott, P.M., McKenna, W.J. J. Am. Coll. Cardiol. (2004)
- RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle. Ricchiuti, V., Apple, F.S. Clin. Chem. (1999)
- Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C. Lindhout, D.A., Li, M.X., Schieve, D., Sykes, B.D. Biochemistry (2002)
- Effects of protein kinase C dependent phosphorylation and a familial hypertrophic cardiomyopathy-related mutation of cardiac troponin I on structural transition of troponin C and myofilament activation. Kobayashi, T., Dong, W.J., Burkart, E.M., Cheung, H.C., Solaro, R.J. Biochemistry (2004)
- Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy. Takahashi-Yanaga, F., Morimoto, S., Harada, K., Minakami, R., Shiraishi, F., Ohta, M., Lu, Q.W., Sasaguri, T., Ohtsuki, I. J. Mol. Cell. Cardiol. (2001)
- Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18. Morrow, D.A., de Lemos, J.A., Sabatine, M.S., Murphy, S.A., Demopoulos, L.A., DiBattiste, P.M., McCabe, C.H., Gibson, C.M., Cannon, C.P., Braunwald, E. J. Am. Coll. Cardiol. (2003)
- Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy. Kimura, A., Harada, H., Park, J.E., Nishi, H., Satoh, M., Takahashi, M., Hiroi, S., Sasaoka, T., Ohbuchi, N., Nakamura, T., Koyanagi, T., Hwang, T.H., Choo, J.A., Chung, K.S., Hasegawa, A., Nagai, R., Okazaki, O., Nakamura, H., Matsuzaki, M., Sakamoto, T., Toshima, H., Koga, Y., Imaizumi, T., Sasazuki, T. Nat. Genet. (1997)
- Ability of minor elevations of troponins I and T to predict benefit from an early invasive strategy in patients with unstable angina and non-ST elevation myocardial infarction: results from a randomized trial. Morrow, D.A., Cannon, C.P., Rifai, N., Frey, M.J., Vicari, R., Lakkis, N., Robertson, D.H., Hille, D.A., DeLucca, P.T., DiBattiste, P.M., Demopoulos, L.A., Weintraub, W.S., Braunwald, E. JAMA (2001)
- Troponin I phosphorylation in the normal and failing adult human heart. Bodor, G.S., Oakeley, A.E., Allen, P.D., Crimmins, D.L., Ladenson, J.H., Anderson, P.A. Circulation (1997)
- Prognostic influence of elevated values of cardiac troponin I in patients with unstable angina. Galvani, M., Ottani, F., Ferrini, D., Ladenson, J.H., Destro, A., Baccos, D., Rusticali, F., Jaffe, A.S. Circulation (1997)
- Troponin T and I assays show decreased concentrations in heparin plasma compared with serum: lower recoveries in early than in late phases of myocardial injury. Gerhardt, W., Nordin, G., Herbert, A.K., Burzell, B.L., Isaksson, A., Gustavsson, E., Haglund, S., Müller-Bardorff, M., Katus, H.A. Clin. Chem. (2000)
- Direct comparison of early elevations of cardiac troponin T and I in patients with clinical unstable angina. Ottani, F., Galvani, M., Ferrini, D., Ladenson, J.H., Puggioni, R., Destro, A., Baccos, D., Bosi, S., Ronchi, A., Rusticali, F., Jaffe, A.S. Am. Heart J. (1999)
- Risk stratification using serum concentrations of cardiac troponin T in patients with end-stage renal disease on chronic maintenance dialysis. Ishii, J., Nomura, M., Okuma, T., Minagawa, T., Naruse, H., Mori, Y., Ishikawa, T., Kurokawa, H., Hirano, T., Kondo, T., Nagamura, Y., Ezaki, K., Hishida, H. Clin. Chim. Acta (2001)
- Performance of a revised cardiac troponin method that minimizes interferences from heterophilic antibodies. Kim, W.J., Laterza, O.F., Hock, K.G., Pierson-Perry, J.F., Kaminski, D.M., Mesguich, M., Braconnier, F., Zimmermann, R., Zaninotto, M., Plebani, M., Hanna, A., Cembrowski, G.S., Scott, M.G. Clin. Chem. (2002)
- Predictive value of perioperative cardiac troponin I for adverse outcome in coronary artery bypass surgery. Eigel, P., van Ingen, G., Wagenpfeil, S. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2001)
- Assignment of the human cardiac troponin I gene (TNNI3) to chromosome 19q13.4 by radiation hybrid mapping. Mogensen, J., Kruse, T.A., Børglum, A.D. Cytogenet. Cell Genet. (1997)
- Novel mutation in cardiac troponin I in recessive idiopathic dilated cardiomyopathy. Murphy, R.T., Mogensen, J., Shaw, A., Kubo, T., Hughes, S., McKenna, W.J. Lancet (2004)
- Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences. Doolan, A., Tebo, M., Ingles, J., Nguyen, L., Tsoutsman, T., Lam, L., Chiu, C., Chung, J., Weintraub, R.G., Semsarian, C. J. Mol. Cell. Cardiol. (2005)
- Structural characterization of the human fast skeletal muscle troponin I gene (TNNI2). Mullen, A.J., Barton, P.J. Gene (2000)
- The human cardiac troponin I locus: assignment to chromosome 19p13.2-19q13.2. MacGeoch, C., Barton, P.J., Vallins, W.J., Bhavsar, P., Spurr, N.K. Hum. Genet. (1991)
- Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil. Wang, X., Li, M.X., Sykes, B.D. J. Biol. Chem. (2002)
- Cardiac troponin C-L29Q, related to hypertrophic cardiomyopathy, hinders the transduction of the protein kinase A dependent phosphorylation signal from cardiac troponin I to C. Schmidtmann, A., Lindow, C., Villard, S., Heuser, A., Mügge, A., Gessner, R., Granier, C., Jaquet, K. FEBS J. (2005)
- Troponin I, troponin T, or creatine kinase-MB to detect perioperative myocardial damage after coronary artery bypass surgery. Bonnefoy, E., Filley, S., Kirkorian, G., Guidollet, J., Roriz, R., Robin, J., Touboul, P. Chest (1998)
- A novel interaction of cGMP-dependent protein kinase I with troponin T. Yuasa, K., Michibata, H., Omori, K., Yanaka, N. J. Biol. Chem. (1999)
- A monoclonal antibody that distinguishes phospho- and dephosphorylated forms of cardiac troponin-I. Cummins, B., Russell, G.J., Cummins, P. Biochem. Soc. Trans. (1991)
- Plasma concentrations of NT-pro-BNP and cardiac troponin-I in relation to doxorubicin-induced cardiomyopathy and cardiac function in childhood malignancy. Soker, M., Kervancioglu, M. Saudi medical journal. (2005)
- Functional consequences of caspase activation in cardiac myocytes. Communal, C., Sumandea, M., de Tombe, P., Narula, J., Solaro, R.J., Hajjar, R.J. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Concentration time courses of troponin and myosin subunits after acute myocardial infarction. Mair, J., Thome-Kromer, B., Wagner, I., Lechleitner, P., Dienstl, F., Puschendorf, B., Michel, G. Coron. Artery Dis. (1994)
- Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils. Kruger, M., Zittrich, S., Redwood, C., Blaudeck, N., James, J., Robbins, J., Pfitzer, G., Stehle, R. J. Physiol. (Lond.) (2005)
- Phosphorylation of human cardiac troponin I G203S and K206Q linked to familial hypertrophic cardiomyopathy affects actomyosin interaction in different ways. Deng, Y., Schmidtmann, A., Kruse, S., Filatov, V., Heilmeyer, L.M., Jaquet, K., Thieleczek, R. J. Mol. Cell. Cardiol. (2003)
- Cardiac troponin I levels are a risk factor for mortality and multiple organ failure in noncardiac critically ill patients and have an additive effect to the APACHE II score in outcome prediction. Wu, T.T., Yuan, A., Chen, C.Y., Chen, W.J., Luh, K.T., Kuo, S.H., Lin, F.Y., Yang, P.C. Shock (2004)