Disease relevance of Speech

• Heart rate, preejection period, respiratory sinus arrhythmia, respiratory rate, norepinephrine, epinephrine, adrenocorticotropic hormone, and cortisol were assessed in 64 healthy older women (mean = 67 years) in response to a mental arithmetic and public-speaking task [1].

Psychiatry related information on Speech

• Moreover, the intensity of the subject's public speaking phobia predicted both degree of prestress anxiety relief from 10 mg diazepam and overall anxiety level, regardless of medication, throughout the experimental session [2].
• In two studies, saliva cortisol responses to the psychological stress of public speaking and mental arithmetic were investigated in women using oral contraceptives (OC; n = 28) and in control women (n = 29) [3].
• Anxiety and salivary cortisol were measured in subjects performing simulated public speaking (SPS), a procedure that has been neurobiologically related to panic disorder [4].

High impact information on Speech

• The plasma cortisol level rose significantly after public speaking in all groups [5].
• Left ventricular (LV) volumes and global and regional function were assessed by radionuclide ventriculography at rest and during two 5-minute standardized mental stress tasks (simulated public speaking and the Stroop Color-Word Test), administered in random order [6].
• Large blood pressure responses during public speaking were associated with high cholesterol levels and low educational attainment [7].
• Four trials were carried out to study the mechanism for this observed platelet secretion: (1) phenoxybenzamine, (2) propranolol, (3) 650 mg aspirin, and (4) 80 mg aspirin were given several hours before the public speaking engagement [8].
• The SBP response to public speaking was greater in the hypertensive subjects with higher systolic daytime BP than in those with lower daytime BP (55.3 +/- 20.9 versus 45.1 +/- 20.6 mmHg, = 0.046) [9].

Biological context of Speech

• The relationship between age at first sexual intercourse and salivary cortisol stress reactivity (to the Trier Social Stress Test; TSST; consisting of public speaking and mental arithmetic) was examined in healthy subjects (43 females and 36 males; ages 19-38) [10].

Associations of Speech with chemical compounds

• Paroxetine modulates psychological and sympathetic responses during public speaking [11].
• Normal male volunteers took single acute doses of either diazepam or placebo under double-blind conditions in three simulated public speaking experiments [2].
• To examine the validity of this hypothesis, we subjected to a video-recorded public-speaking stress seven healthy persons, six type I diabetics with stable blood glucose levels and six type I diabetics with unstable or brittle diabetes (with more than 10 hypoglycaemia/month and frequent hyperglycaemia) [12].
• In a double blind design, forty healthy male volunteers were exposed to a brief psychological stressor (public speaking) and received a single oral dose of dexamethasone [DEX] (N=20) or placebo (N=20) the evening before the main experiment [13].
• Ritanserin facilitates anxiety in a simulated public-speaking paradigm [14].

Gene context of Speech

• The effects of ritanserin, a 5-HT2A/2C (5-hydroxytryptamine) antagonist, have been investigated in simulated public speaking with healthy volunteers [14].
• All the subjects were exposed to the same psychosocial stressor (Stroop Color-Word Interference Task, public speaking and mental arithmetic in front of an audience) 3 weeks after MDMA discontinuation [15].
• 3. Beta blockers appear to be of use in specific social phobias, like public speaking [16].

Analytical, diagnostic and therapeutic context of Speech

• METHODS: Eighteen schizophrenic patients were compared to 21 healthy controls in their salivary cortisol response to a physical (bicycle ergometry) and a psychosocial (public speaking) stressor [17].
• To further explore the role of serotonin (5-HT) in anxiety, 28 healthy volunteers received in a double-blind study d-fenfluramine (30 mg, p.o.) or placebo, and were submitted to a simulated public speaking test (SPS), consisting of speaking in front of a video camera [18].

References