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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Speech


Psychiatry related information on Speech

  • Moreover, the intensity of the subject's public speaking phobia predicted both degree of prestress anxiety relief from 10 mg diazepam and overall anxiety level, regardless of medication, throughout the experimental session [2].
  • In two studies, saliva cortisol responses to the psychological stress of public speaking and mental arithmetic were investigated in women using oral contraceptives (OC; n = 28) and in control women (n = 29) [3].
  • Anxiety and salivary cortisol were measured in subjects performing simulated public speaking (SPS), a procedure that has been neurobiologically related to panic disorder [4].

High impact information on Speech

  • The plasma cortisol level rose significantly after public speaking in all groups [5].
  • Left ventricular (LV) volumes and global and regional function were assessed by radionuclide ventriculography at rest and during two 5-minute standardized mental stress tasks (simulated public speaking and the Stroop Color-Word Test), administered in random order [6].
  • Large blood pressure responses during public speaking were associated with high cholesterol levels and low educational attainment [7].
  • Four trials were carried out to study the mechanism for this observed platelet secretion: (1) phenoxybenzamine, (2) propranolol, (3) 650 mg aspirin, and (4) 80 mg aspirin were given several hours before the public speaking engagement [8].
  • The SBP response to public speaking was greater in the hypertensive subjects with higher systolic daytime BP than in those with lower daytime BP (55.3 +/- 20.9 versus 45.1 +/- 20.6 mmHg, = 0.046) [9].

Biological context of Speech

  • The relationship between age at first sexual intercourse and salivary cortisol stress reactivity (to the Trier Social Stress Test; TSST; consisting of public speaking and mental arithmetic) was examined in healthy subjects (43 females and 36 males; ages 19-38) [10].

Associations of Speech with chemical compounds

  • Paroxetine modulates psychological and sympathetic responses during public speaking [11].
  • Normal male volunteers took single acute doses of either diazepam or placebo under double-blind conditions in three simulated public speaking experiments [2].
  • To examine the validity of this hypothesis, we subjected to a video-recorded public-speaking stress seven healthy persons, six type I diabetics with stable blood glucose levels and six type I diabetics with unstable or brittle diabetes (with more than 10 hypoglycaemia/month and frequent hyperglycaemia) [12].
  • In a double blind design, forty healthy male volunteers were exposed to a brief psychological stressor (public speaking) and received a single oral dose of dexamethasone [DEX] (N=20) or placebo (N=20) the evening before the main experiment [13].
  • Ritanserin facilitates anxiety in a simulated public-speaking paradigm [14].

Gene context of Speech


Analytical, diagnostic and therapeutic context of Speech


  1. Cardiovascular and endocrine reactivity in older females: intertask consistency. Hawkley, L.C., Burleson, M.H., Poehlmann, K.M., Berntson, G.G., Malarkey, W.B., Cacioppo, J.T. Psychophysiology. (2001) [Pubmed]
  2. Simulated public speaking as a model of clinical anxiety. McNair, D.M., Frankenthaler, L.M., Czerlinsky, T., White, T.W., Sasson, S., Fisher, S. Psychopharmacology (Berl.) (1982) [Pubmed]
  3. Preliminary evidence for reduced cortisol responsivity to psychological stress in women using oral contraceptive medication. Kirschbaum, C., Pirke, K.M., Hellhammer, D.H. Psychoneuroendocrinology (1995) [Pubmed]
  4. Anxiety and salivary cortisol in symptomatic and nonsymptomatic panic patients and healthy volunteers performing simulated public speaking. Garcia-Leal, C., Parente, A.C., Del-Ben, C.M., Guimarães, F.S., Moreira, A.C., Elias, L.L., Graeff, F.G. Psychiatry research. (2005) [Pubmed]
  5. Psychological stress and metabolic control in patients with type I diabetes mellitus. Kemmer, F.W., Bisping, R., Steingrüber, H.J., Baar, H., Hardtmann, F., Schlaghecke, R., Berger, M. N. Engl. J. Med. (1986) [Pubmed]
  6. Left ventricular, peripheral vascular, and neurohumoral responses to mental stress in normal middle-aged men and women. Reference Group for the Psychophysiological Investigations of Myocardial Ischemia (PIMI) Study. Becker, L.C., Pepine, C.J., Bonsall, R., Cohen, J.D., Goldberg, A.D., Coghlan, C., Stone, P.H., Forman, S., Knatterud, G., Sheps, D.S., Kaufmann, P.G. Circulation (1996) [Pubmed]
  7. Menopausal status influences ambulatory blood pressure levels and blood pressure changes during mental stress. Owens, J.F., Stoney, C.M., Matthews, K.A. Circulation (1993) [Pubmed]
  8. Platelet activation and secretion associated with emotional stress. Levine, S.P., Towell, B.L., Suarez, A.M., Knieriem, L.K., Harris, M.M., George, J.N. Circulation (1985) [Pubmed]
  9. The white-coat effect is unrelated to the difference between clinic and daytime blood pressure and is associated with greater reactivity to public speaking. Palatini, P., Palomba, D., Bertolo, O., Minghetti, R., Longo, D., Sarlo, M., Pessina, A.C. J. Hypertens. (2003) [Pubmed]
  10. Age at first intercourse is inversely related to female cortisol stress reactivity. Brody, S. Psychoneuroendocrinology (2002) [Pubmed]
  11. Paroxetine modulates psychological and sympathetic responses during public speaking. Golding, M., Kotlyar, M., Garbutt, J.C., Guzzo, J., Sontz, E., Hinderliter, A., Carson, S.W. Journal of clinical psychopharmacology. (2002) [Pubmed]
  12. Hormonal response to stress in brittle diabetes. Dutour, A., Boiteau, V., Dadoun, F., Feissel, A., Atlan, C., Oliver, C. Psychoneuroendocrinology (1996) [Pubmed]
  13. Cortisol mediates redistribution of CD8+ but not of CD56+ cells after the psychological stress of public speaking. Hennig, J., Netter, P., Voigt, K.H. Psychoneuroendocrinology (2001) [Pubmed]
  14. Ritanserin facilitates anxiety in a simulated public-speaking paradigm. Guimarães, F.S., Mbaya, P.S., Deakin, J.F. J. Psychopharmacol. (Oxford) (1997) [Pubmed]
  15. Hypothalamic-pituitary-adrenal axis responses to stress in subjects with 3,4-methylenedioxy-methamphetamine ('ecstasy') use history: correlation with dopamine receptor sensitivity. Gerra, G., Bassignana, S., Zaimovic, A., Moi, G., Bussandri, M., Caccavari, R., Brambilla, F., Molina, E. Psychiatry research. (2003) [Pubmed]
  16. Recent advances in the psychopharmacology of social phobia. Den Boer, J.A., Van Vliet, I.M., Westenberg, H.G. Prog. Neuropsychopharmacol. Biol. Psychiatry (1994) [Pubmed]
  17. Selective impairments in the stress response in schizophrenic patients. Jansen, L.M., Gispen-de Wied, C.C., Kahn, R.S. Psychopharmacology (Berl.) (2000) [Pubmed]
  18. D-fenfluramine reduces anxiety induced by simulated public speaking. Hetem, L.A., de-Souza, C.J., Guimarães, F.S., Zuardi, A.W., Graeff, F.G. Braz. J. Med. Biol. Res. (1993) [Pubmed]
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