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MeSH Review

Arrhythmia, Sinus

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Disease relevance of Arrhythmia, Sinus


High impact information on Arrhythmia, Sinus

  • Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy [6].
  • Dose/response studies in humans and rhesus monkeys are cited as an example for interspecies comparisons using ED50 calculations for a 30% decrease in the respiratory sinus arrhythmias following atropine [7].
  • Respiratory sinus arrhythmias are quantified following atropine sulfate administration and the resulting vagolytic blockade is used as a pharmacologic challenge technique [7].
  • The extent of sinus arrhythmia suppression was inversely correlated with the degree of M1 selectivity of the drugs used, advocating the use of M1-selective antiparkinsonian anticholinergics like biperiden in the treatment of extrapyramidal side effects [8].
  • Melatonin decreased heart rate by 3.66+/-1.68 beats/min (P<0.05) and pre-ejection period (measure of cardiac sympathetic activity) by 16.48+/-4.28 ms (P<0.05), but had no effect on respiratory sinus arrhythmia (measure of cardiac parasympathetic activity) (P>0.05) [9].

Chemical compound and disease context of Arrhythmia, Sinus


Biological context of Arrhythmia, Sinus


Anatomical context of Arrhythmia, Sinus


Gene context of Arrhythmia, Sinus

  • Surprisingly, however, a recent study in anesthetized rats paradoxically found an enhancement of cardiac vagal activity during inspiration, suggesting that rats have an inverted respiratory sinus arrhythmia (Rentero N, Cividjian A, Trevaks D, Pequignot JM, Quintin L, and McAllen RM. Am J Physiol Regul Integr Comp Physiol 283: R1327-R1334, 2002) [17].
  • ADHD subjects showed less respiratory sinus arrhythmia than normal children but were similarly responsive to tone stimuli [18].
  • Extent of sinus arrhythmia tended to be highest in quiet sleep (QS), lower in active or REM sleep (AS), and lowest in waking (AW), especially after 2 months of age [19].
  • Pulmonary function, heart period (milliseconds between heart beats), and respiratory sinus arrhythmia (a measure of cardiac vagal tone) were assessed before drug administration and 45 min thereafter [20].
  • Respiratory sinus arrhythmia as a predictor of outcome in major depressive disorder [21].

Analytical, diagnostic and therapeutic context of Arrhythmia, Sinus


  1. Sleep-induced apnea syndrome. Prevalence of cardiac arrhythmias and their reversal after tracheostomy. Tilkian, A.G., Guilleminault, C., Schroeder, J.S., Lehrman, K.L., Simmons, F.B., Dement, W.C. Am. J. Med. (1977) [Pubmed]
  2. Effect of amitraz on heart rate and aortic blood pressure in conscious dogs: influence of atropine, prazosin, tolazoline, and yohimbine. Hsu, W.H., Lu, Z.X., Hembrough, F.B. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  3. Influence of nifedipine on xylazine-induced acute pressor response in halothane-anesthetized dogs. Tranquilli, W.J., Thurmon, J.C., Paul, A.J., Benson, G.J. Am. J. Vet. Res. (1985) [Pubmed]
  4. Corticotropin-releasing factor modulates cardiovascular and pupillary autonomic reflexes in man: is there a link to inflammation-induced autonomic nervous hyperreflexia? Pongratz, G., Zietz, B., Glück, T., Schölmerich, J., Straub, R.H. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  5. Echocardiographic study of mitral valve prolapse in dachshunds. Pedersen, H.D., Kristensen Bø, n.u.l.l., Nørby, B., Lorentzen, K.A. Zentralblatt für Veterinärmedizin. Reihe A. (1996) [Pubmed]
  6. Diminishment of respiratory sinus arrhythmia foreshadows doxorubicin-induced cardiomyopathy. Hrushesky, W.J., Fader, D.J., Berestka, J.S., Sommer, M., Hayes, J., Cope, F.O. Circulation (1991) [Pubmed]
  7. Pharmacologic challenges for establishing interspecies extrapolation models in neurotoxicology. Dellinger, J.A. Neuroscience and biobehavioral reviews. (1991) [Pubmed]
  8. Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics. Avissar, S., Schreiber, G. Biol. Psychiatry (1989) [Pubmed]
  9. The effects of day-time exogenous melatonin administration on cardiac autonomic activity. Harris, A.S., Burgess, H.J., Dawson, D. J. Pineal Res. (2001) [Pubmed]
  10. Does the sympathetic nervous system influence sinus arrhythmia in man? Evidence from combined autonomic blockade. Coker, R., Koziell, A., Oliver, C., Smith, S.E. J. Physiol. (Lond.) (1984) [Pubmed]
  11. CO2-dependent components of sinus arrhythmia from the start of breath holding in humans. Cooper, H.E., Parkes, M.J., Clutton-Brock, T.H. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  12. Ketamine inhibits inspiratory-evoked gamma-aminobutyric acid and glycine neurotransmission to cardiac vagal neurons in the nucleus ambiguus. Wang, X., Huang, Z.G., Dergacheva, O., Bouairi, E., Gorini, C., Stephens, C., Andresen, M.C., Mendelowitz, D. Anesthesiology (2005) [Pubmed]
  13. Halothane and cardiac autonomic control in infants: assessment with quantitative respiratory sinus arrhythmia. Oberlander, T.F., Berde, C.B., Saul, J.P. Pediatr. Res. (1996) [Pubmed]
  14. Respiratory sinus arrhythmia during recovery from isoflurane-nitrous oxide anesthesia. Donchin, Y., Feld, J.M., Porges, S.W. Anesth. Analg. (1985) [Pubmed]
  15. Muscarinic cholinergic receptors modulate vagal cardiac responses in man. Raczkowska, M., Eckberg, D.L., Ebert, T.J. J. Auton. Nerv. Syst. (1983) [Pubmed]
  16. Sinus arrhythmia in children with atrial septal defect: an analysis of heart rate variability before and after surgical repair. Finley, J.P., Nugent, S.T., Hellenbrand, W., Craig, M., Gillis, D.A. British heart journal. (1989) [Pubmed]
  17. Respiratory sinus arrhythmia in freely moving and anesthetized rats. Bouairi, E., Neff, R., Evans, C., Gold, A., Andresen, M.C., Mendelowitz, D. J. Appl. Physiol. (2004) [Pubmed]
  18. Baseline respiratory sinus arrhythmia and heart-rate responses during auditory stimulation of children with attention-deficit hyperactivity disorder. Shibagaki, M., Furuya, T. Perceptual and motor skills. (1997) [Pubmed]
  19. Development of sinus arrhythmia during sleeping and waking states in normal infants. Harper, R.M., Walter, D.O., Leake, B., Hoffman, H.J., Sieck, G.C., Sterman, M.B., Hoppenbrouwers, T., Hodgman, J. Sleep. (1978) [Pubmed]
  20. Effects of aerosol ipratropium bromide on cardiac vagal tone. Lehrer, P.M., Hochron, S.M., Rausch, L., Carr, R. Chest (1994) [Pubmed]
  21. Respiratory sinus arrhythmia as a predictor of outcome in major depressive disorder. Rottenberg, J., Wilhelm, F.H., Gross, J.J., Gotlib, I.H. Journal of affective disorders. (2002) [Pubmed]
  22. Clinical comparison of medetomidine with xylazine/l-methadone in dogs. Kramer, S., Nolte, I., Jöchle, W. Vet. Rec. (1996) [Pubmed]
  23. Fractal ventilation enhances respiratory sinus arrhythmia. Mutch, W.A., Graham, M.R., Girling, L.G., Brewster, J.F. Respir. Res. (2005) [Pubmed]
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