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Chemical Compound Review

Cyclogyl     2-dimethylaminoethyl 2-(1...

Synonyms: Mydrilate, Cylate, Diopentolate, Ciclopentolato, Cyclopentoiate, ...
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Disease relevance of cyclopentolate


High impact information on cyclopentolate


Chemical compound and disease context of cyclopentolate


Biological context of cyclopentolate


Anatomical context of cyclopentolate


Associations of cyclopentolate with other chemical compounds


Gene context of cyclopentolate

  • Five eyes of 3 patients had a difference of 0.50 D or greater between the 2 agents; less myopia with cyclopentolate [26].
  • Near-point testing revealed less residual accommodation with cyclopentolate (difference in MSE, OD=-0.27 +/- 0.51 D, t=2.68, P=.006; OS=-0.32 +/- 0.49 D, t=3.46, P=.001) [26].
  • The average of five successful consecutive refraction and keratometry readings were obtained with calibrated Canon RK5 autokeratorefractometers by well trained optometry students, at least 30 minutes after the instillation of the third drop of cyclopentolate [27].
  • Children exposed to organophosphate insecticides and other pseudocholinesterase inhibitors may be at risk for cyclopentolate toxicity [28].
  • Examinations include a detailed assessment of visual acuity, cover testing for strabismus, identification of amblyopia, slit-lamp examination, non-contact ocular biometry and cycloplegia (cyclopentolate) followed by autorefraction, optical coherence tomography, retinal thickness measurement, digital mydriatic retinal photography and aberrometry [29].

Analytical, diagnostic and therapeutic context of cyclopentolate


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  2. Effects of cyclopentolate eyedrops on gastric secretory function in pre-term infants. Isenberg, S.J., Abrams, C., Hyman, P.E. Ophthalmology (1985) [Pubmed]
  3. Cycloplegic refraction in esotropic children. Cyclopentolate versus atropine. Rosenbaum, A.L., Bateman, J.B., Bremer, D.L., Liu, P.Y. Ophthalmology (1981) [Pubmed]
  4. Generalised urticaria induced by topical cyclopentolate. Newman, D.K., Jordan, K. Eye (London, England) (1996) [Pubmed]
  5. Muscarinic cholinoceptor regulation of cyclic guanosine monophosphate in human corneal epithelium. Walkenbach, R.J., Ye, G.S. Invest. Ophthalmol. Vis. Sci. (1991) [Pubmed]
  6. Comparison of 6-month results of implantation of the 1CU accommodative intraocular lens with conventional intraocular lenses. Küchle, M., Seitz, B., Langenbucher, A., Gusek-Schneider, G.C., Martus, P., Nguyen, N.X. Ophthalmology (2004) [Pubmed]
  7. Analysis of patients with good uncorrected distance and near vision after monofocal intraocular lens implantation. Nanavaty, M.A., Vasavada, A.R., Patel, A.S., Raj, S.M., Desai, T.H. Journal of cataract and refractive surgery. (2006) [Pubmed]
  8. Drug-induced intraocular lens movement and near visual acuity after AcrySof intraocular lens implantation. Muftuoglu, O., Hosal, B.M., Karel, F., Zilelioglu, G. Journal of cataract and refractive surgery. (2005) [Pubmed]
  9. The effect of cycloplegia on measurement of the ocular components. Mutti, D.O., Zadnik, K., Egashira, S., Kish, L., Twelker, J.D., Adams, A.J. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  10. A comparative study of the efficacy of 2.5% phenylephrine and 10% phenylephrine in pre-operative mydriasis for routine cataract surgery. Tanner, V., Casswell, A.G. Eye (London, England) (1996) [Pubmed]
  11. Ocular toxicology. Novack, G.D. Current opinion in ophthalmology. (1997) [Pubmed]
  12. Possible allergic reactions to cyclopentolate hydrochloride: case reports with literature review of uses and adverse reactions. Jones, L.W., Hodes, D.T. Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). (1991) [Pubmed]
  13. Evaluation of surgical performance with intracameral mydriatics in phacoemulsification surgery. Behndig, A., Eriksson, A. Acta ophthalmologica Scandinavica. (2004) [Pubmed]
  14. Intraocular lens movement caused by ciliary muscle contraction. Findl, O., Kiss, B., Petternel, V., Menapace, R., Georgopoulos, M., Rainer, G., Drexler, W. Journal of cataract and refractive surgery. (2003) [Pubmed]
  15. Changes in intraocular pressure following diagnostic mydriasis with cyclopentolate 1%. Hancox, J., Murdoch, I., Parmar, D. Eye (London, England) (2002) [Pubmed]
  16. The effect of some macromolecular ionic complexes on the pharmacokinetics and -dynamics of ocular cyclopentolate in rabbits. Huupponen, R., Kaila, T., Saettone, M.F., Monti, D., Ilsalo, E., Salminen, L., Oksala, O. Journal of ocular pharmacology. (1992) [Pubmed]
  17. Systemic absorption of ocular cyclopentolate in children. Lahdes, K., Huupponen, R., Kaila, T., Ali-Melkkilä, T., Salminen, L., Saari, M. German journal of ophthalmology. (1992) [Pubmed]
  18. Stimulus-driven versus pilocarpine-induced biometric changes in pseudophakic eyes. Kriechbaum, K., Findl, O., Koeppl, C., Menapace, R., Drexler, W. Ophthalmology (2005) [Pubmed]
  19. Posterior capsule opacification after phacoemulsification in patients with diabetes mellitus. Zaczek, A., Zetterström, C. Journal of cataract and refractive surgery. (1999) [Pubmed]
  20. Ultrasound biomicroscopic study of ciliary body thickness after topical application of pharmacologic agents. Mishima, H.K., Shoge, K., Takamatsu, M., Kiuchi, Y., Tanaka, J. Am. J. Ophthalmol. (1996) [Pubmed]
  21. Effects of mydriatic agents on neutrophil migration. Tsai, E., Till, G.O., Marak, G.E. Ophthalmic Res. (1988) [Pubmed]
  22. Systemic reactions to ophthalmic drug preparations. Fraunfelder, F.T., Meyer, S.M. Medical toxicology and adverse drug experience. (1987) [Pubmed]
  23. Retinoscopy in infants using a near noncycloplegic technique, cycloplegia with tropicamide 1%, and cycloplegia with cyclopentolate 1%. Twelker, J.D., Mutti, D.O. Optometry and vision science : official publication of the American Academy of Optometry. (2001) [Pubmed]
  24. The maintenance of per-operative mydriasis in phacoemulsification with topical diclofenac sodium. Antcliff, R.J., Trew, D.R. Eye (London, England) (1997) [Pubmed]
  25. Microbore liquid chromatography of tertiary amine anticholinergic pharmaceuticals with tris(2,2'-bipyridine)ruthenium(III) chemiluminescence detection. Holeman, J.A., Danielson, N.D. Journal of chromatographic science. (1995) [Pubmed]
  26. Comparison of tropicamide and cyclopentolate for cycloplegic refractions in myopic adult refractive surgery patients. Hofmeister, E.M., Kaupp, S.E., Schallhorn, S.C. Journal of cataract and refractive surgery. (2005) [Pubmed]
  27. Defining myopia using refractive error and uncorrected logMAR visual acuity >0.3 from 1334 Singapore school children ages 7-9 years. Luo, H.D., Gazzard, G., Liang, Y., Shankar, A., Tan, D.T., Saw, S.M. The British journal of ophthalmology. (2006) [Pubmed]
  28. Grand mal seizure in a child 30 minutes after Cyclogyl (cyclopentolate hydrochloride) and 10% Neo-Synephrine (phenylephrine hydrochloride) eye drops were instilled. Demayo, A.P., Reidenberg, M.M. Pediatrics (2004) [Pubmed]
  29. Methods for a population-based study of myopia and other eye conditions in school children: the Sydney Myopia Study. Ojaimi, E., Rose, K.A., Smith, W., Morgan, I.G., Martin, F.J., Mitchell, P. Ophthalmic epidemiology. (2005) [Pubmed]
  30. Pseudophakic accommodation and pseudoaccommodation under physiological conditions measured with partial coherence interferometry. Tsorbatzoglou, A., Németh, G., Máth, J., Berta, A. Journal of cataract and refractive surgery. (2006) [Pubmed]
  31. Plasma concentrations and ocular effects of cyclopentolate after ocular application of three formulations. Lahdes, K., Huupponen, R., Kaila, T., Monti, D., Saettone, M.F., Salminen, L. British journal of clinical pharmacology. (1993) [Pubmed]
  32. Is post-cataract mydriasis necessary? Teimory, M., Davey, K., Marsh, I.B. Eye (London, England) (1993) [Pubmed]
  33. Ocular dimensions and refraction in Tibetan children. Garner, L.F., Yap, M.K., Kinnear, R.F., Frith, M.J. Optometry and vision science : official publication of the American Academy of Optometry. (1995) [Pubmed]
  34. Can retinoscopy be used to screen infants for amblyopia? A longitudinal study of refraction in the first year of life. Hopkisson, B., Arnold, P., Billingham, B., McGarrigle, M., Shribman, S. Eye (London, England) (1992) [Pubmed]
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