Disease relevance of Dacryocystitis

• The presence of corneal opacities associated with dacryoadenitis and lacrimal gland destruction has led investigators to consider MRL/Mp mice as models for band keratopathy and Sjögren syndrome [1].
• Experimental autoimmune dacryoadenitis was produced in Lewis rats by immunization with a single intradermal administration of a 3M KCl extract of exorbital lacrimal gland in CFA, when enhanced by simultaneous i.v. injection of killed Bordetella pertussis [2].
• Role of the ICAM-1/LFA-1 pathway during the development of autoimmune dacryoadenitis in an animal model for Sjögren's syndrome [3].
• Toxicity was mild to moderate, and was comprised primarily of fatigue, diarrhea, dacryocystitis, and fluid retention (in the IL-2 cohort) [4].
• Dacryocystorhinostomy for dacryocystitis caused by methicillin- resistant Staphylococcus aureus: report of four cases [5].

High impact information on Dacryocystitis

• Additionally, HBD-2 mRNA was detected in epithelial samples from patients with dacryocystitis [6].
• Leakage of aquaporin 5 in the tear of dacryoadenitis mice [7].
• METHODS: Female MRL/lpr (24-week-old), male NOD/Shi Jci (5-, 8-, and 10-week-old), female NFS/s-TX (10-week-old), and lipopolysaccharide (LPS)-induced dacryoadenitis model mice were used [7].
• Experimental autoimmune dacryoadenitis. I. Lacrimal gland disease in the rat [2].
• High incidence of autoimmune dacryoadenitis in male non-obese diabetic (NOD) mice depending on sex steroid [8].

Chemical compound and disease context of Dacryocystitis

• In LPS-induced dacryoadenitis model mice, either tissue destruction with inflammation in LG or AQP5 leakage in the tear was observed [7].
• Apart from myoepithelial cells and some luminal-duct cells, the remaining epithelia in dacryoadenitis were negative with AB 34 beta E12 (CK 5) [9].
• Clinically the combination of bacitracin and neomycin, primarily used in half of the patients as initial therapy, was successful in curing the dacryocystitis in 82.5% of all patients [10].
• Treatment of experimental autoimmune dacryoadenitis with cyclosporin A [11].
• The dacryocystitis resolved with intravenous antibiotics, aspiration of the lacrimal sacs, injection of sulfacetamide into the lacrimal sacs, and bilateral dacryocystorhinostomy [12].

Anatomical context of Dacryocystitis

• Vimentin was negative in epithelial cells in dacryoadenitis except in one case [9].

Gene context of Dacryocystitis

• PURPOSE: To evaluate the effect of tumor necrosis factor (TNF) inhibitor protein on lacrimal gland immunopathology and ocular surface disease resulting from induced dacryoadenitis [13].
• CONCLUSION: Dacryocystitis due to MRSA was resistant to conservative therapy [5].
• Experimental autoimmune dacryoadenitis: purification and characterization of a lacrimal gland antigen [14].
• Atrophic acini in dacryoadenitis reacted with antibodies (ABs) KL1 and Pkk1 (CK 7, 8, 17, 18) in a manner similar to ducts [9].
• Epithelia in dacryoadenitis reacted weakly but consistently with Lf while revealing weak and inconsistent staining for Ly [9].

Analytical, diagnostic and therapeutic context of Dacryocystitis

• PURPOSE: To evaluate the efficacy of intralesional injection of steroid as a new line of therapy in treatment of the acute form of an isolated idiopathic dacryoadenitis [15].

References