Disease relevance of Cerebellar Neoplasms

• Synergy between the Shh and PI3K signaling pathways are implicated in the cerebellar tumor medulloblastoma [1].
• In light of earlier reports on the association of JCV with PNETs in humans and the involvement of the Wnt signaling pathway in the development of cerebellar tumors, we investigated the interplay between T-antigen and beta-catenin, the key protein of the Wnt pathway [2].
• The diagnosis should be suspected in patients who present with slowly progressive sensorineural hearing loss and ataxia many years after eradication of a childhood cerebellar tumor [3].
• Lhermitte-Duclos disease (LDD) is a rare cerebellar tumor associated with Cowden disease (CD) and germline mutations in the PTEN gene [4].
• A 70-year-old woman is reported who had glioblastoma multiforme of the cerebellum 52 years after radiation therapy to a midline cerebellar tumor [5].

High impact information on Cerebellar Neoplasms

• Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation [6].
• Unlike p53, loss of the Arf tumor suppressor did not contribute to the appearance of vascular or cerebellar tumors [7].
• Amplification of the N-myc gene was detected in two cerebellar tumors both of which exhibited neuronal differentiation by light microscopy [8].
• Morphological and immunohistochemical evidence for the presence of subcortical target cells of N-ethyl-N-nitrosourea-induced cerebellar tumors in rats [9].
• In situ hybridization with catalyzed signal amplification and polymerase chain reactions with primers specific for human papilloma virus (HPV) types 16 and 18 were used to determine the relationship between the cervical and the cerebellar neoplasms [10].

Chemical compound and disease context of Cerebellar Neoplasms

• After failing to tolerate tamoxifen therapy, she received Megace, with marked improvement in her cerebellar tumor on CT scans [11].
• A 4-year-old boy was admitted for the treatment of a cerebellar tumor and, following total removal of the tumor, he was treated with combination chemotherapy consisting of cisplatin, vinblastine, and bleomycin [12].

Biological context of Cerebellar Neoplasms

• A heterozygous frameshift mutation of the PTEN/MMAC1 gene in a patient with Lhermitte-Duclos disease - only the mutated allele was expressed in the cerebellar tumor [13].

Anatomical context of Cerebellar Neoplasms

• Here we describe cloning and long-term culture of heterogeneous neural cell lines from a multifocal cerebellar neoplasm that arose in an adult p53-/- mutant mouse [14].

Gene context of Cerebellar Neoplasms

• Five of the 20 primary cerebellar tumors contained weakly GFAP-positive foci [15].
• Scattered nuclei were stained by Ki-67 in primary and metastatic cerebellar tumor [16].
• It was absent in cerebellar tumors. p53-positive tumors had a higher MIB-1 LI, compared to p53-negative tumors (p=0.003) [17].
• The authors report on the case of a 6-year-old boy who underwent resection of a midline cerebellar tumor [18].

References