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MeSH Review

Intestinal Polyps

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Disease relevance of Intestinal Polyps


High impact information on Intestinal Polyps

  • A Ptgs2 null mutation reduced the number and size of the intestinal polyps dramatically [6].
  • Exposure of Apc(min) mice to the PPAR-delta ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps [7].
  • Here we show that Lkb1(+/-) mice develop intestinal polyps identical to those seen in individuals affected with PJS [8].
  • Homozygous gene knockout for other PGE(2) receptors, EP1 or EP3, did not affect intestinal polyp formation in Apc(Delta 716) mice [2].
  • Interestingly, we found the loss of one p85alpha allele with or without the loss of p85beta led to increased incidence of intestinal polyps [9].

Chemical compound and disease context of Intestinal Polyps


Biological context of Intestinal Polyps


Anatomical context of Intestinal Polyps


Gene context of Intestinal Polyps

  • Transfer of the Apc(Min) allele onto a homozygous Egfr(wa2) background results in a 90% reduction in intestinal polyp number relative to Apc(Min) mice carrying a wild-type Egfr allele [19].
  • These results suggest that the reduced APC protein level increases intestinal polyp multiplicity through quantitative stimulation of the beta-catenin/T-cell factor transcription [20].
  • A recent study showed that Cdx2 null mutation was embryonically lethal, whereas Cdx2+/- mice developed multiple intestinal polyps in the proximal colon in addition to developmental defects [21].
  • Analysis by immunohistochemistry of intestinal polyps in mice heterozygous for the multiple intestinal neoplasia gene (Min/+) at 5 months revealed an increase and redistribution of VEGF-A in proximity to those cells expressing nuclear beta-catenin with a corresponding increase in vessel density [22].
  • As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice [23].

Analytical, diagnostic and therapeutic context of Intestinal Polyps


  1. The APCI1307K allele and cancer risk in a community-based study of Ashkenazi Jews. Woodage, T., King, S.M., Wacholder, S., Hartge, P., Struewing, J.P., McAdams, M., Laken, S.J., Tucker, M.A., Brody, L.C. Nat. Genet. (1998) [Pubmed]
  2. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice. Sonoshita, M., Takaku, K., Sasaki, N., Sugimoto, Y., Ushikubi, F., Narumiya, S., Oshima, M., Taketo, M.M. Nat. Med. (2001) [Pubmed]
  3. Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice. Niho, N., Mutoh, M., Takahashi, M., Tsutsumi, K., Sugimura, T., Wakabayashi, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Overexpression of the nonpancreatic secretory group II PLA2 messenger RNA and protein in colorectal adenomas from familial adenomatous polyposis patients. Kennedy, B.P., Soravia, C., Moffat, J., Xia, L., Hiruki, T., Collins, S., Gallinger, S., Bapat, B. Cancer Res. (1998) [Pubmed]
  5. No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice. Takaku, K., Wrana, J.L., Robertson, E.J., Taketo, M.M. Cancer Res. (2002) [Pubmed]
  6. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Oshima, M., Dinchuk, J.E., Kargman, S.L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J.M., Evans, J.F., Taketo, M.M. Cell (1996) [Pubmed]
  7. Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Gupta, R.A., Wang, D., Katkuri, S., Wang, H., Dey, S.K., DuBois, R.N. Nat. Med. (2004) [Pubmed]
  8. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Bardeesy, N., Sinha, M., Hezel, A.F., Signoretti, S., Hathaway, N.A., Sharpless, N.E., Loda, M., Carrasco, D.R., DePinho, R.A. Nature (2002) [Pubmed]
  9. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Luo, J., Sobkiw, C.L., Logsdon, N.M., Watt, J.M., Signoretti, S., O'Connell, F., Shin, E., Shim, Y., Pao, L., Neel, B.G., Depinho, R.A., Loda, M., Cantley, L.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. Mutoh, M., Watanabe, K., Kitamura, T., Shoji, Y., Takahashi, M., Kawamori, T., Tani, K., Kobayashi, M., Maruyama, T., Kobayashi, K., Ohuchida, S., Sugimoto, Y., Narumiya, S., Sugimura, T., Wakabayashi, K. Cancer Res. (2002) [Pubmed]
  11. Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(Delta716) mouse intestinal polyps. Seno, H., Oshima, M., Ishikawa, T.O., Oshima, H., Takaku, K., Chiba, T., Narumiya, S., Taketo, M.M. Cancer Res. (2002) [Pubmed]
  12. Chemopreventive effects of dietary folate on intestinal polyps in Apc+/-Msh2-/- mice. Song, J., Sohn, K.J., Medline, A., Ash, C., Gallinger, S., Kim, Y.I. Cancer Res. (2000) [Pubmed]
  13. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Niho, N., Takahashi, M., Kitamura, T., Shoji, Y., Itoh, M., Noda, T., Sugimura, T., Wakabayashi, K. Cancer Res. (2003) [Pubmed]
  14. Effects of docosahexaenoic acid (DHA) on intestinal polyp development in Apc delta 716 knockout mice. Oshima, M., Takahashi, M., Oshima, H., Tsutsumi, M., Yazawa, K., Sugimura, T., Nishimura, S., Wakabayashi, K., Taketo, M.M. Carcinogenesis (1995) [Pubmed]
  15. Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Dashwood, W.M., Orner, G.A., Dashwood, R.H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  16. Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice. Taketo, M.M., Takaku, K. Hum. Cell (2000) [Pubmed]
  17. Silencing of CDX2 expression in colon cancer via a dominant repression pathway. Hinoi, T., Loda, M., Fearon, E.R. J. Biol. Chem. (2003) [Pubmed]
  18. Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis. Kitamura, T., Kawamori, T., Uchiya, N., Itoh, M., Noda, T., Matsuura, M., Sugimura, T., Wakabayashi, K. Carcinogenesis (2002) [Pubmed]
  19. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Roberts, R.B., Min, L., Washington, M.K., Olsen, S.J., Settle, S.H., Coffey, R.J., Threadgill, D.W. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  20. The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Li, Q., Ishikawa, T.O., Oshima, M., Taketo, M.M. Cancer Res. (2005) [Pubmed]
  21. Homeosis and polyposis: a tale from the mouse. He, T.C., da Costa, L.T., Thiagalingam, S. Bioessays (1997) [Pubmed]
  22. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Easwaran, V., Lee, S.H., Inge, L., Guo, L., Goldbeck, C., Garrett, E., Wiesmann, M., Garcia, P.D., Fuller, J.H., Chan, V., Randazzo, F., Gundel, R., Warren, R.S., Escobedo, J., Aukerman, S.L., Taylor, R.N., Fantl, W.J. Cancer Res. (2003) [Pubmed]
  23. Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. Kitamura, T., Itoh, M., Noda, T., Matsuura, M., Wakabayashi, K. Int. J. Cancer (2004) [Pubmed]
  24. Food restriction inhibits the growth of intestinal polyps in multiple intestinal neoplasia mouse. Kakuni, M., Morimura, K., Wanibuchi, H., Ogawa, M., Min, W., Hayashi, S., Fukushima, S. Jpn. J. Cancer Res. (2002) [Pubmed]
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