Gene Review:
Stk11 - serine/threonine kinase 11
Mus musculus
Synonyms:
AA408040, LKB1, Liver kinase B1 homolog, Lkb1, Par-4, ...
- Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. Udd, L., Katajisto, P., Rossi, D.J., Lepistö, A., Lahesmaa, A.M., Ylikorkala, A., Järvinen, H.J., Ristimäki, A.P., Mäkelä, T.P. Gastroenterology (2004)
- Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas. Takeda, H., Miyoshi, H., Tamai, Y., Oshima, M., Taketo, M.M. Br. J. Cancer (2004)
- Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Bardeesy, N., Sinha, M., Hezel, A.F., Signoretti, S., Hathaway, N.A., Sharpless, N.E., Loda, M., Carrasco, D.R., DePinho, R.A. Nature (2002)
- Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Ylikorkala, A., Rossi, D.J., Korsisaari, N., Luukko, K., Alitalo, K., Henkemeyer, M., Mäkelä, T.P. Science (2001)
- Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Jishage, K., Nezu, J., Kawase, Y., Iwata, T., Watanabe, M., Miyoshi, A., Ose, A., Habu, K., Kake, T., Kamada, N., Ueda, O., Kinoshita, M., Jenne, D.E., Shimane, M., Suzuki, H. Proc. Natl. Acad. Sci. U.S.A. (2002)
- The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Smith, D.P., Spicer, J., Smith, A., Swift, S., Ashworth, A. Hum. Mol. Genet. (1999)
- Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Miyoshi, H., Nakau, M., Ishikawa, T.O., Seldin, M.F., Oshima, M., Taketo, M.M. Cancer Res. (2002)
- Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Wei, C., Amos, C.I., Stephens, L.C., Campos, I., Deng, J.M., Behringer, R.R., Rashid, A., Frazier, M.L. Cancer Res. (2005)
- Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Nakau, M., Miyoshi, H., Seldin, M.F., Imamura, M., Oshima, M., Taketo, M.M. Cancer Res. (2002)
- Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Takeda, H., Miyoshi, H., Kojima, Y., Oshima, M., Taketo, M.M. Oncogene (2006)