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Chemical Compound Review

Cobalt-57     cobalt

Synonyms: AC1L2XM8, 13981-50-5, Cobalt, isotope of mass 57
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Disease relevance of cobalt


High impact information on cobalt

  • Using oriented epitaxial Co2+: ZnO films grown by chemical vapor deposition, kinetics measurements demonstrate a direct correlation between the oxidative quenching of ferromagnetism and the diffusion and oxidation of interstitial zinc [6].
  • In a separate series of experiments, the Na+ flux across the blood-brain barrier was studied by injecting 22NaCl together with an intravascular reference (cobalt-57-labeled microspheres 15 microns in diameter) into the ischemic area [7].
  • Measurement of total-body cobalt-57 vitamin B12 absorption with a gamma camera [8].
  • Central venous pressure line localization with a cobalt-57 marker system [9].
  • For two different murine monoclonal antibodies, the average chelator content obtained by terbium fluorescence titration correlated closely with that measured by the cobalt-57 binding assay [10].

Biological context of cobalt


Anatomical context of cobalt


Associations of cobalt with other chemical compounds


Analytical, diagnostic and therapeutic context of cobalt

  • Uniformity correction for SPECT using a mapped cobalt-57 sheet source [19].
  • This inhibitor coordinates the metal center through four interactions as follows: (i) ligation of the N-terminal (3R)-nitrogen to Co2, (ii, iii) bridging coordination of the (2S)-hydroxyl group, and (iv) terminal ligation to Co1 by the keto oxygen of the pseudo-peptide linkage [20].


  1. Monitoring of 57Co-bleomycin delivery to brain metastases and their tumors of origin. Front, D., Even-Sapir, E., Iosilevsky, G., Israel, O., Frenkel, A., Kolodny, G.M., Feinsud, M. J. Neurosurg. (1987) [Pubmed]
  2. 57Co-bleomycin scintigraphy for the staging of lung cancer. Nieweg, O.E., Piers, D.A., Beekhuis, H., Sluiter, H.J., van der Wal, A.M., Woldring, M.G. Cancer (1989) [Pubmed]
  3. Cobalt-57 SPET in relapsing-progressive multiple sclerosis: a pilot study. Joosten, A.A., Jansen, H.M., Piers, D.A., Minderhoud, J.M., Korf, J. Nuclear medicine communications. (1995) [Pubmed]
  4. Internal radiotherapy for hepatic metastases II: The blood supply to hepatic metastases. Stribley, K.V., Gray, B.N., Chmiel, R.L., Heggie, J.C., Bennett, R.C. J. Surg. Res. (1983) [Pubmed]
  5. In vivo measurements of the fraction of dose of bleomycin labeled with cobalt 57 delivered to human tumors. Front, D., Even-Sapir, E., Israel, O., Iosilevsky, G., Frenkel, A., Milstein, D., Epelbaum, R., Robinson, E., Kolodny, G.M. Cancer (1991) [Pubmed]
  6. Direct kinetic correlation of carriers and ferromagnetism in Co2+: ZnO. Kittilstved, K.R., Schwartz, D.A., Tuan, A.C., Heald, S.M., Chambers, S.A., Gamelin, D.R. Phys. Rev. Lett. (2006) [Pubmed]
  7. Effect of enhanced capillary activity on the blood-brain barrier during focal cerebral ischemia in cats. Shigeno, T., Asano, T., Mima, T., Takakura, K. Stroke (1989) [Pubmed]
  8. Measurement of total-body cobalt-57 vitamin B12 absorption with a gamma camera. Cardarelli, J.A., Slingerland, D.W., Burrows, B.A., Miller, A. J. Nucl. Med. (1985) [Pubmed]
  9. Central venous pressure line localization with a cobalt-57 marker system. DeLuca, S.A., Castronovo, F.P. Radiology. (1981) [Pubmed]
  10. Characterization of antibody-chelator conjugates: determination of chelator content by terbium fluorescence titration. Brandt, K.D., Schnobrich, K.E., Johnson, D.K. Bioconjug. Chem. (1991) [Pubmed]
  11. A practical SPECT technique for quantitation of drug delivery to human tumors and organ absorbed radiation dose. Iosilevsky, G., Israel, O., Frenkel, A., Even-Sapir, E., Ben-Haim, S., Front, A., Kolodny, G.M., Front, D. Seminars in nuclear medicine. (1989) [Pubmed]
  12. Measurement of pulmonary edema in intact dogs by transthoracic gamma-ray attenuation. Simon, D.S., Murray, J.F., Staub, N.C. Journal of applied physiology: respiratory, environmental and exercise physiology. (1979) [Pubmed]
  13. Heterogeneity of blood flow in tibial cortical bone: an experimental investigation using microspheres. Willans, S.M., McCarthy, I.D. J. Orthop. Res. (1991) [Pubmed]
  14. Lung toxicity of hard metal particles and production of interleukin-1, tumor necrosis factor-alpha, fibronectin, and cystatin-c by lung phagocytes. Huaux, F., Lasfargues, G., Lauwerys, R., Lison, D. Toxicol. Appl. Pharmacol. (1995) [Pubmed]
  15. Assessment of cobalt 57 tagged bleomycin as a clinical aid in staging of head and neck carcinoma. Cummings, C.W., Larson, S.M., Dobie, R.A., Weymuller, E.A., Rudd, T.G., Merello, A. Laryngoscope (1981) [Pubmed]
  16. Cobalt-57 as a SPET tracer in the visualization of ischaemic brain damage in patients with middle cerebral artery stroke. Stevens, H., Knollema, S., Piers, D.A., Van de Wiele, C., Jansen, H.M., De Jager, A.E., De Reuck, J., Dierckx, R.A., Korf, J. Nuclear medicine communications. (1998) [Pubmed]
  17. Regional pulmonary distribution of iodine-125-labeled oleic acid. Its relationship to the pattern of oleic acid edema and pulmonary blood flow. Tarver, R.D., Tsai, J., Hedlund, L.W., Sullivan, D.C., Lischko, M.M., Harris, C.C., Effmann, E.L., Putman, C.E. Investigative radiology. (1986) [Pubmed]
  18. Labelling of bleomycin with cobalt-57, indium-111, technetium-99m, mercury-197, lead-203, and copper-67. van de Poll, M.A., Versluis, A., Rasker, J.J., Jurjens, H., Woldring, M.G. Nuklearmedizin. (1976) [Pubmed]
  19. Uniformity correction for SPECT using a mapped cobalt-57 sheet source. Oppenheim, B.E., Appledorn, C.R. J. Nucl. Med. (1985) [Pubmed]
  20. Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis. Lowther, W.T., Orville, A.M., Madden, D.T., Lim, S., Rich, D.H., Matthews, B.W. Biochemistry (1999) [Pubmed]
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