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Chemical Compound Review

KST-1A4368     (3R,4S)-2-[6- (cyclohexylamino)purin-9- yl]...

Synonyms: AC1L2XRK, AR-1A6160, AC1Q4Y27, 36396-99-3, N(6)-Cyclohexyladenosine, ...
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Disease relevance of Adenosine, N-cyclohexyl-


Psychiatry related information on Adenosine, N-cyclohexyl-

  • Adenosine A(1) receptor agonists N(6)-cyclohexyladenosine (CHA) or N(6)-phenylisopropyladenosine (R-PIA) only at the higher doses used, and adenosine A(2) receptor agonist 5'-N-ethylcarboxaminoadenosine (NECA), at all doses used, decreased morphine-induced amnesia in a dose-dependent manner [4].

High impact information on Adenosine, N-cyclohexyl-


Chemical compound and disease context of Adenosine, N-cyclohexyl-


Biological context of Adenosine, N-cyclohexyl-


Anatomical context of Adenosine, N-cyclohexyl-

  • In the fully kindled animals, N(6)-cyclohexyladenosine (CHA), a selective A(1) receptor agonist, and 1,3-dimethyl-8-cyclopenthylxanthine (CPT), a selective A(1) receptor antagonist, were microinjected bilaterally into the EC (group 1) or amygdala (group 2) [13].

Gene context of Adenosine, N-cyclohexyl-


  1. Involvement of the cerebellar adenosine A(1) receptor in cannabinoid-induced motor incoordination in the acute and tolerant state in mice. DeSanty, K.P., Dar, M.S. Brain Res. (2001) [Pubmed]
  2. Multiple actions of extracellular ATP and adenosine on calcium currents mediated by various purinoceptors in neurons of nucleus tractus solitarius. Aoki, Y., Yamada, E., Endoh, T., Suzuki, T. Neurosci. Res. (2004) [Pubmed]
  3. Characterization of N(6)-cyclohexyladenosine-induced hypothermia in Syrian hamsters. Shintani, M., Tamura, Y., Monden, M., Shiomi, H. J. Pharmacol. Sci. (2005) [Pubmed]
  4. The effects of adenosine receptor agonists and antagonists on morphine state-dependent memory of passive avoidance. Khavandgar, S., Homayoun, H., Torkaman-Boutorabi, A., Zarrindast, M.R. Neurobiology of learning and memory. (2002) [Pubmed]
  5. Adenosine activates aromatic L-amino acid decarboxylase activity in the kidney and increases dopamine. Takezako, T., Noda, K., Tsuji, E., Koga, M., Sasaguri, M., Arakawa, K. J. Am. Soc. Nephrol. (2001) [Pubmed]
  6. Mechanisms linking adenosine A1 receptors and extracellular signal-regulated kinase 1/2 activation in human trabecular meshwork cells. Husain, S., Shearer, T.W., Crosson, C.E. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  7. Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation. Cordeaux, Y., Ijzerman, A.P., Hill, S.J. Br. J. Pharmacol. (2004) [Pubmed]
  8. A(2A) adenosine receptor ligands and proinflammatory cytokines induce PC 12 cell death through apoptosis. Trincavelli, M.L., Falleni, A., Chelli, B., Tuscano, D., Costa, B., Gremigni, V., Lucacchini, A., Martini, C. Biochem. Pharmacol. (2003) [Pubmed]
  9. Inhibition of lipolysis causes suppression of endogenous glucose production independent of changes in insulin. Mittelman, S.D., Bergman, R.N. Am. J. Physiol. Endocrinol. Metab. (2000) [Pubmed]
  10. Co-modulation of acute ethanol-induced motor impairment by mouse cerebellar adenosinergic A(1) and GABA(A) receptor systems. Saeed Dar, M. Brain Res. Bull. (2006) [Pubmed]
  11. Influence of beta-adrenoceptor tone on the cardioprotective efficacy of adenosine A(1) receptor activation in isolated working rat hearts. Ford, W.R., Jugdutt, B.I., Lopaschuk, G.D., Schulz, R., Clanachan, A.S. Br. J. Pharmacol. (2000) [Pubmed]
  12. Modification of cardiovascular responses to adenosine A1 receptor stimulation in the posterior hypothalamus of anaesthetized rats by cAMP and by GABA(B) receptor blockade. Lee, H.H., Koh, H.C., Chae, S.L., Kang, J.S., Lee, C.H., Paik, D.J., Shin, I.C. Journal of autonomic pharmacology. (2001) [Pubmed]
  13. The role of adenosine A(1) receptors in the interaction between amygdala and entorhinal cortex of kindled rats. Mohammad-Zadeh, M., Amini, A., Mirnajafi-Zadeh, J., Fathollahi, Y. Epilepsy Res. (2005) [Pubmed]
  14. Adenosine A1 receptors regulate the response of the mouse circadian clock to light. Sigworth, L.A., Rea, M.A. Brain Res. (2003) [Pubmed]
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