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Gene Review

Adora1  -  adenosine A1 receptor

Rattus norvegicus

Synonyms: Adenosine receptor A1
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Disease relevance of Adora1


Psychiatry related information on Adora1


High impact information on Adora1


Chemical compound and disease context of Adora1


Biological context of Adora1


Anatomical context of Adora1


Associations of Adora1 with chemical compounds


Physical interactions of Adora1


Regulatory relationships of Adora1

  • The mechanism by which activation of the adenosine A3 receptor induces bronchospasm is distinct from the mechanism by which activation of the adenosine A1 receptor induces bronchospasm [27].
  • Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine [28].
  • A parallel Fos detection indicates that this discrepancy may be due to the excitatory action of the medial parabrachial nucleus at the rostral pontine level that surpasses inhibitory influence of the adenosine A1 receptor activation at the medullary level particularly in the ventrolateral reticular nucleus of the medulla [29].
  • Activation of inhibitory G-proteins by the adenosine A1 receptor analogue N6-phenylisopropyladenosine at 10(-6) mol/l completely blocked NE stimulated calcitonin secretion [30].
  • The adenosine A1 receptor analogue N-6 phenylisopropyl-adenosine (PIA) (10(-10)-10(-6) M) inhibits dose-dependently glucagon (10(-7) M) and rGRH (10(-7) M) stimulated cAMP formation and calcitonin secretion [31].

Other interactions of Adora1


Analytical, diagnostic and therapeutic context of Adora1


  1. Adenosine A(1) receptor antagonist and mitochondrial ATP-sensitive potassium channel blocker attenuate the tolerance to focal cerebral ischemia in rats. Yoshida, M., Nakakimura, K., Cui, Y.J., Matsumoto, M., Sakabe, T. J. Cereb. Blood Flow Metab. (2004) [Pubmed]
  2. Study of an adenosine A1 receptor agonist on trigeminally evoked dural blood vessel dilation in the anaesthetized rat. Honey, A.C., Bland-Ward, P.A., Connor, H.E., Feniuk, W., Humphrey, P.P. Cephalalgia : an international journal of headache. (2002) [Pubmed]
  3. Increase of adenosine A1 receptor gene expression in cerebral ischemia of Wistar rats. Lai, D.M., Tu, Y.K., Liu, I.M., Cheng, J.T. Neurosci. Lett. (2005) [Pubmed]
  4. Adenosine receptor subtypes and vasodilatation in rat skeletal muscle during systemic hypoxia: a role for A1 receptors. Bryan, P.T., Marshall, J.M. J. Physiol. (Lond.) (1999) [Pubmed]
  5. Effects of adenosine receptor subtypes on hippocampal extracellular serotonin level and serotonin reuptake activity. Okada, M., Kawata, Y., Kiryu, K., Mizuno, K., Wada, K., Tasaki, H., Kaneko, S. J. Neurochem. (1997) [Pubmed]
  6. Adenosine A1 receptor agonist GR79236 suppresses apnea during all sleep stages in the rat. Carley, D.W., Hagan, R.M., Sheehan, M., Trbovic, S., Thai, T., Radulovacki, M. Sleep. (1997) [Pubmed]
  7. Adenosine A1 receptors mediate inhibition of cAMP formation in vitro in the pontine, REM sleep induction zone. Marks, G.A., Birabil, C.G., Speciale, S.G. Brain Res. (2005) [Pubmed]
  8. Adenosine A1 receptor-dependent G-protein activity in the rat brain during prolonged wakefulness. Alanko, L.O., Laitinen, J.T., Stenberg, D., Porkka-Heiskanen, T. Neuroreport (2004) [Pubmed]
  9. Effects of adenosine receptor agonists and antagonists in amphetamine-induced conditioned place preference test in rats. Poleszak, E., Malec, D. Polish journal of pharmacology. (2003) [Pubmed]
  10. Adenosine formed by 5'-nucleotidase mediates tubuloglomerular feedback. Thomson, S., Bao, D., Deng, A., Vallon, V. J. Clin. Invest. (2000) [Pubmed]
  11. Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accumulation. The role of N-methyl-D-aspartate receptors. Bong, G.W., Rosengren, S., Firestein, G.S. J. Clin. Invest. (1996) [Pubmed]
  12. Evidence for deactivation of both ectosolic and cytosolic 5'-nucleotidase by adenosine A1 receptor activation in the rat cardiomyocytes. Kitakaze, M., Hori, M., Minamino, T., Takashima, S., Komamura, K., Node, K., Kurihara, T., Morioka, T., Sato, H., Inoue, M. J. Clin. Invest. (1994) [Pubmed]
  13. Activation of adenosine A1-receptor pathway induces edema formation in the pancreas of rats. Satoh, A., Shimosegawa, T., Satoh, K., Ito, H., Kohno, Y., Masamune, A., Fujita, M., Toyota, T. Gastroenterology (2000) [Pubmed]
  14. The role of intraspinal adenosine A1 receptors in sympathetic regulation. Peng, S.C., Ho, C.M., Ho, S.T., Tsai, S.K., Su, C.K. Eur. J. Pharmacol. (2004) [Pubmed]
  15. Role of adenosine receptors in the paradoxic bradycardia response of rats to inferior vena cava occlusion during an infusion of isoproterenol. Waxman, M.B., Asta, J.A. Circulation (1998) [Pubmed]
  16. Ischemic preconditioning and glucose metabolism during low-flow ischemia: role of the adenosine A1 receptor. de Jonge, R., de Jong, J.W. Cardiovasc. Res. (1999) [Pubmed]
  17. Group 1 mGlu receptors elevate [Ca2+]i in rat cultured cortical type 2 astrocytes: [Ca2+]i synergy with adenosine A1 receptors. Toms, N.J., Roberts, P.J. Neuropharmacology (1999) [Pubmed]
  18. Adenosine A1 receptor down-regulation in mothers and fetal brain after caffeine and theophylline treatments to pregnant rats. León, D., Albasanz, J.L., Ruíz, M.A., Fernández, M., Martín, M. J. Neurochem. (2002) [Pubmed]
  19. Role of central and peripheral adenosine receptors in the cardiovascular responses to intraperitoneal injections of adenosine A1 and A2A subtype receptor agonists. Schindler, C.W., Karcz-Kubicha, M., Thorndike, E.B., Müller, C.E., Tella, S.R., Ferré, S., Goldberg, S.R. Br. J. Pharmacol. (2005) [Pubmed]
  20. Inhibition of glycolysis and enhanced mechanical function of working rat hearts as a result of adenosine A1 receptor stimulation during reperfusion following ischaemia. Finegan, B.A., Lopaschuk, G.D., Gandhi, M., Clanachan, A.S. Br. J. Pharmacol. (1996) [Pubmed]
  21. Valerian extract Ze 911 inhibits postsynaptic potentials by activation of adenosine A1 receptors in rat cortical neurons. Vissiennon, Z., Sichardt, K., Koetter, U., Brattström, A., Nieber, K. Planta Med. (2006) [Pubmed]
  22. Adenosine A1 receptor distribution in the nucleus tractus solitarii of normotensive and spontaneously hypertensive rats. Carrettiero, D.C., Fior-Chadi, D.R. Journal of neural transmission (Vienna, Austria : 1996) (2004) [Pubmed]
  23. Characterization of adenosine-A1 receptor-mediated antilipolysis in rats by tissue microdialysis, 1H-spectroscopy, and glucose clamp studies. Schoelch, C., Kuhlmann, J., Gossel, M., Mueller, G., Neumann-Haefelin, C., Belz, U., Kalisch, J., Biemer-Daub, G., Kramer, W., Juretschke, H.P., Herling, A.W. Diabetes (2004) [Pubmed]
  24. Effects of long-term theophylline exposure on recovery of respiratory function and expression of adenosine A1 mRNA in cervical spinal cord hemisected adult rats. Nantwi, K.D., Basura, G.J., Goshgarian, H.G. Exp. Neurol. (2003) [Pubmed]
  25. Orexin neurons of the hypothalamus express adenosine A1 receptors. Thakkar, M.M., Winston, S., McCarley, R.W. Brain Res. (2002) [Pubmed]
  26. A new milrinone analog: role of binding to A1 adenosine receptor in its positive inotropic effect on isolated guinea pig and rat atria. Floreani, M., Borea, P.A., Gessi, S., Mosti, L., Fossa, P., Dorigo, P. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  27. In vivo role of the adenosine A3 receptor: N6-2-(4-aminophenyl)ethyladenosine induces bronchospasm in BDE rats by a neurally mediated mechanism involving cells resembling mast cells. Meade, C.J., Mierau, J., Leon, I., Ensinger, H.A. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  28. Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine. Okamura, N., Hashimoto, K., Shimizu, E., Kumakiri, C., Komatsu, N., Iyo, M. Neuropsychopharmacology (2004) [Pubmed]
  29. Involvement of adenosinergic A1 systems in the occurrence of respiratory perturbations encountered in newborns following an in utero caffeine exposure. a study on brainstem-spinal cord preparations isolated from newborn rats. Saadani-Makki, F., Frugière, A., Gros, F., Gaytan, S., Bodineau, L. Neuroscience (2004) [Pubmed]
  30. Norepinephrine induced calcitonin secretion in rat medullary thyroid carcinoma 6-23 cells: interaction between intracellular calcium and cAMP. Zink-Lorenz, A., Komitowska, J., Raue, F. Exp. Clin. Endocrinol. Diabetes (1996) [Pubmed]
  31. Adenosine A1-receptors inhibit cAMP and Ca2+ mediated calcitonin secretion in C-cells. Zink, A., Scherübl, H., Höflich, M., Hescheler, J., Raue, F. Horm. Metab. Res. (1995) [Pubmed]
  32. Role of adenosine A1 receptor in the regulation of gastrin release. Yip, L., Leung, H.C., Kwok, Y.N. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  33. Characterisation of ATP-induced facilitation of transmission in rat hippocampus. O'Kane, E.M., Stone, T.W. Eur. J. Pharmacol. (2000) [Pubmed]
  34. Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent. Lasley, R.D., Keith, B.J., Kristo, G., Yoshimura, Y., Mentzer, R.M. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  35. Repeated cocaine administration alters the expression of genes in corticolimbic circuitry after a 3-week withdrawal: a DNA macroarray study. Toda, S., McGinty, J.F., Kalivas, P.W. J. Neurochem. (2002) [Pubmed]
  36. Evidence for functionally important adenosine A2a receptors in the rat hippocampus. Cunha, R.A., Johansson, B., van der Ploeg, I., Sebastião, A.M., Ribeiro, J.A., Fredholm, B.B. Brain Res. (1994) [Pubmed]
  37. Activation of adenosine A2 receptors enhances high K(+)-evoked taurine release from rat hippocampus: a microdialysis study. Hada, J., Kaku, T., Morimoto, K., Hayashi, Y., Nagai, K. Amino Acids (1998) [Pubmed]
  38. Inhibitory effect of ischemic preconditioning on leukocyte participation in retinal ischemia-reperfusion injury. Nonaka, A., Kiryu, J., Tsujikawa, A., Yamashiro, K., Nishijima, K., Miyamoto, K., Nishiwaki, H., Honda, Y., Ogura, Y. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
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