Disease relevance of DICHLOROPHENOL

• Estimation of the yield coefficient of Pseudomonas sp. strain DP-4 with a low substrate (2,4-dichlorophenol [DCP]) concentration in a mineral medium from which uncharacterized organic compounds were eliminated by a non-DCP-degrading organism [1].
• Effects of 2,4-D and DCP on the DHT-induced androgenic action in human prostate cancer cells [2].
• Aids for in vitro Mycobacterium lepraemurium investigations: estimation of oxidation-reduction potentials and pO2 with 2, 6 dichlorophenol indophenol [3].
• Validation of osmotic fragility test and dichlorophenol indophenol precipitation test for screening of thalassemia and hb e [4].

High impact information on DICHLOROPHENOL

• Pseudomonas strains capable of mineralizing 2,4-dichlorophenol (DCP) and p-nitrophenol (PNP) in culture media were isolated from soil [5].
• On the other hand, several variously substituted sulfonephthaleins, of different pK2 values, mediated the laccase catalysis, the most efficient being dichlorophenol red, which has the lowest pK2 of the series [6].
• As a result, the oxidative decarboxylation of pyruvate catalysed by E1 in the presence of dichlorophenol indophenol as an artificial electron acceptor is markedly enhanced, but the reductive acetylation of a free lipoyl domain is unchanged [7].
• The kinetics for DCP were much slower than those for phenol, and the largest effect was a half-maximum rate concentration, which was 19 times larger for DCP [8].
• The biomass completely dechlorinated DCP and utilized all of the substrates simultaneously as electron donors and carbon sources [8].

Chemical compound and disease context of DICHLOROPHENOL

• The oxidation-reduction potential (ORP) of NC-5, an aerobic, cysteine containing medium which supports the limited in vitro growth of Mycobacterium lepraemurium, is measurable with the redox dye, 2, 6 dichlorophenol indophenol [3].

Associations of DICHLOROPHENOL with other chemical compounds

• Impacts of COD and DCP loading rates on biological treatment of 2,4-dichlorophenol (DCP) containing wastewater in a perforated tubes biofilm reactor [9].
• Results, in experiments with DCP and PQ, have varied from no change to increase or decrease in the measured monooxygenase activities and cytochrome P450 content [10].
• The effect of DCP on the sorption of NA gradually increased with decreasing pH from 10.8 to 6.7, suggesting a stronger effect of neutral DCP than that of the ionic species on the sorption of NA [11].
• Increases have been recorded in two cases (NADPH ferricyanide reductase and cytochrome P450) after exposure to DCP and in the case of NADH ferricyanide reductase following the exposure to PQ [10].

Gene context of DICHLOROPHENOL

• Living organisms in pure culture and those naturally found in soil were shown to reduce 2,3-dichlorophenol indophenol (DCIP) and the tetrazolium dye 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide inner salt (XTT) [12].

Analytical, diagnostic and therapeutic context of DICHLOROPHENOL

• The enzymatic results were supported by genetic investigations by which the presence of the genes tfdB (encoding a dichlorophenol hydroxylase), tfdC (encoding a chlorocatechol 1,2-dioxygenase) and tfdD (encoding a chloromuconate cycloisomerase) could be demonstrated in both strains by PCR after application of respective primers [13].

References