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Chemical Compound Review

Asiatic acid     (1S,2R,4aS,6aR,6aS,6bR,8aR,9S, 10S,11R,12aS...

Synonyms: S2266_Selleck, CHEMBL404313, CHEBI:2873, SureCN3285999, HSDB 7662, ...
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Disease relevance of Asiatic acid


Psychiatry related information on Asiatic acid


High impact information on Asiatic acid


Biological context of Asiatic acid


Anatomical context of Asiatic acid


Associations of Asiatic acid with other chemical compounds


Gene context of Asiatic acid


Analytical, diagnostic and therapeutic context of Asiatic acid


  1. Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. Hsu, Y.L., Kuo, P.L., Lin, L.T., Lin, C.C. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  2. Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. Lee, Y.S., Jin, D.Q., Kwon, E.J., Park, S.H., Lee, E.S., Jeong, T.C., Nam, D.H., Huh, K., Kim, J.A. Cancer Lett. (2002) [Pubmed]
  3. Glioblastoma cell death induced by asiatic acid. Cho, C.W., Choi, D.S., Cardone, M.H., Kim, C.W., Sinskey, A.J., Rha, C. Cell Biol. Toxicol. (2006) [Pubmed]
  4. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Park, B.C., Bosire, K.O., Lee, E.S., Lee, Y.S., Kim, J.A. Cancer Lett. (2005) [Pubmed]
  5. Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells. Bunpo, P., Kataoka, K., Arimochi, H., Nakayama, H., Kuwahara, T., Vinitketkumnuen, U., Ohnishi, Y. J. Med. Invest. (2005) [Pubmed]
  6. Asiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicity. Lee, M.K., Kim, S.R., Sung, S.H., Lim, D., Kim, H., Choi, H., Park, H.K., Je, S., Ki, Y.C. Res. Commun. Mol. Pathol. Pharmacol. (2000) [Pubmed]
  7. Structure-activity relationship study of asiatic acid derivatives against beta amyloid (A beta)-induced neurotoxicity. Jew, S.S., Yoo, C.H., Lim, D.Y., Kim, H., Mook-Jung, I., Jung, M.W., Choi, H., Jung, Y.H., Kim, H., Park, H.G. Bioorg. Med. Chem. Lett. (2000) [Pubmed]
  8. Structure-activity relationship study of asiatic acid derivatives for new wound healing agent. Jeong, B.S. Arch. Pharm. Res. (2006) [Pubmed]
  9. Pharmacokinetics of the total triterpenic fraction of Centella asiatica after single and multiple administrations to healthy volunteers. A new assay for asiatic acid. Grimaldi, R., De Ponti, F., D'Angelo, L., Caravaggi, M., Guidi, G., Lecchini, S., Frigo, G.M., Crema, A. Journal of ethnopharmacology. (1990) [Pubmed]
  10. The comparative steady-state bioavailability of the active ingredients of Madecassol. Rush, W.R., Murray, G.R., Graham, D.J. European journal of drug metabolism and pharmacokinetics. (1993) [Pubmed]
  11. Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid. Gurfinkel, D.M., Chow, S., Hurren, R., Gronda, M., Henderson, C., Berube, C., Hedley, D.W., Schimmer, A.D. Apoptosis (2006) [Pubmed]
  12. Triterpenoids and their glycosides from the bark of Schefflera octophylla. Sung, T.V., Lavaud, C., Porzel, A., Steglich, W., Adam, G. Phytochemistry (1992) [Pubmed]
  13. Centella asiatica (Indian pennywort), an effective therapeutic but a weak sensitizer. Hausen, B.M. Contact Derm. (1993) [Pubmed]
  14. Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors. Caballero-George, C., Vanderheyden, P.M., Okamoto, Y., Masaki, T., Mbwambo, Z., Apers, S., Gupta, M.P., Pieters, L., Vauquelin, G., Vlietinck, A. Phytotherapy research : PTR. (2004) [Pubmed]
  15. Determination of a new asiatic acid derivative, AS 2-006A in rat plasma and urine, and human plasma by high-performance liquid chromatography. Kim, G.B., Kim, Y.G., Jew, S.S., Lee, M.G. Res. Commun. Mol. Pathol. Pharmacol. (1999) [Pubmed]
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