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Chemical Compound Review

Arcyriarubin A     3,4-bis(1H-indol-3- yl)pyrrole-2,5-dione

Synonyms: BIM-4, PubChem12895, CHEMBL266487, SureCN624896, BIM IV, ...
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Disease relevance of K00203


High impact information on K00203


Chemical compound and disease context of K00203


Biological context of K00203


Anatomical context of K00203


Associations of K00203 with other chemical compounds


Gene context of K00203


Analytical, diagnostic and therapeutic context of K00203


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  14. LDL oxidized by hypochlorous acid causes irreversible platelet aggregation when combined with low levels of ADP, thrombin, epinephrine, or macrophage-derived chemokine (CCL22). Coleman, L.G., Polanowska-Grabowska, R.K., Marcinkiewicz, M., Gear, A.R. Blood (2004) [Pubmed]
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  17. Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta. Ridge, K.M., Dada, L., Lecuona, E., Bertorello, A.M., Katz, A.I., Mochly-Rosen, D., Sznajder, J.I. Mol. Biol. Cell (2002) [Pubmed]
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  19. Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin action. Vigliotta, G., Miele, C., Santopietro, S., Portella, G., Perfetti, A., Maitan, M.A., Cassese, A., Oriente, F., Trencia, A., Fiory, F., Romano, C., Tiveron, C., Tatangelo, L., Troncone, G., Formisano, P., Beguinot, F. Mol. Cell. Biol. (2004) [Pubmed]
  20. Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide. Willems, F., Amraoui, Z., Vanderheyde, N., Verhasselt, V., Aksoy, E., Scaffidi, C., Peter, M.E., Krammer, P.H., Goldman, M. Blood (2000) [Pubmed]
  21. Protein kinase C alpha/beta inhibitor Go6976 promotes formation of cell junctions and inhibits invasion of urinary bladder carcinoma cells. Koivunen, J., Aaltonen, V., Koskela, S., Lehenkari, P., Laato, M., Peltonen, J. Cancer Res. (2004) [Pubmed]
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  26. Alpha 1-adrenergic inhibition of the beta-adrenergically activated Cl- current in guinea pig ventricular myocytes. Oleksa, L.M., Hool, L.C., Harvey, R.D. Circ. Res. (1996) [Pubmed]
  27. Pituitary adenylate cyclase-activating polypeptide and melatonin in the suprachiasmatic nucleus: effects on the calcium signal transduction cascade. Kopp, M.D., Schomerus, C., Dehghani, F., Korf, H.W., Meissl, H. J. Neurosci. (1999) [Pubmed]
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  29. Bisindolylmaleimide I Suppresses Fibroblast Growth Factor-mediated Activation of Erk MAP Kinase in Chondrocytes by Preventing Shp2 Association with the Frs2 and Gab1 Adaptor Proteins. Krejci, P., Masri, B., Salazar, L., Farrington-Rock, C., Prats, H., Thompson, L.M., Wilcox, W.R. J. Biol. Chem. (2007) [Pubmed]
  30. Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. Amos, S., Martin, P.M., Polar, G.A., Parsons, S.J., Hussaini, I.M. J. Biol. Chem. (2005) [Pubmed]
  31. Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions. Browning, J.L., Patel, T., Brandt, P.C., Young, K.A., Holcomb, L.A., Hicks, P.B. Biol. Psychiatry (2005) [Pubmed]
  32. Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C. Korzick, D.H., Muller-Delp, J.M., Dougherty, P., Heaps, C.L., Bowles, D.K., Krick, K.K. Cardiovasc. Res. (2005) [Pubmed]
  33. Overexpression of myristoylated alanine-rich C-kinase substrate enhances activation of phospholipase D by protein kinase C in SK-N-MC human neuroblastoma cells. Morash, S.C., Rosé, S.D., Byers, D.M., Ridgway, N.D., Cook, H.W. Biochem. J. (1998) [Pubmed]
  34. Transcription factor phosphorylation by pp90(rsk2). Identification of Fos kinase and NGFI-B kinase I as pp90(rsk2). Swanson, K.D., Taylor, L.K., Haung, L., Burlingame, A.L., Landreth, G.E. J. Biol. Chem. (1999) [Pubmed]
  35. Cerebrovascular alterations in protein kinase C-mediated constriction in stroke-prone rats. Smeda, J.S., King, S., Harder, D.R. Stroke (1999) [Pubmed]
  36. In vivo mechanisms of vascular endothelial growth factor-mediated increased hydraulic conductivity of Rana capillaries. Pocock, T.M., Bates, D.O. J. Physiol. (Lond.) (2001) [Pubmed]
  37. Direct block by bisindolylmaleimide of rat Kv1.5 expressed in Chinese hamster ovary cells. Choi, B.H., Choi, J.S., Jeong, S.W., Hahn, S.J., Yoon, S.H., Jo, Y.H., Kim, M.S. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  38. Vascular endothelial growth factor stimulates differential signaling pathways in in vivo microcirculation. Aramoto, H., Breslin, J.W., Pappas, P.J., Hobson, R.W., Durán, W.N. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
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