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Chemical Compound Review:

AR-1J3471 (2S)-1-[(2S)-2-[[(2S)-6- amino-2-[[(2S)-2...

Synonyms: AC1L3U9V, 77739-21-0, beta-Neoendorphin, beta-neo-endorphin, Big leu-enkephalin, ...

Suda, M. et al., Xie, G.X. et al., Seizinger, B.R. et al., Lorenz, R.G. et al., Zamir, N. et al., et al.

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Disease relevance of beta-neo-endorphin

Dehydration significantly reduced the concentration of immunoreactive dynorphin A(1-17), dynorphin A(1-8), alpha-neo-endorphin, beta-neo-endorphin, and leu-enkephalin in the rat pituitary posterior-intermediate lobe [1].

High impact information on beta-neo-endorphin

To examine the processing of products of the dynorphin gene in the central nervous system, immunoreactive (ir) dynorphin (Dyn) A, Dyn B, Dyn A-(1-8), alpha- and beta-neo-endorphin (alpha- and beta-Neo) in rat brain and spinal cord were measured, using specific antisera after gel filtration and high-performance liquid chromatography (HPLC) [2].
The olfactory bulb has the lowest beta-neo-endorphin concentration (21.3 fmol/mg of protein) [3].
The highest concentration of beta-neo-endorphin in brain was found in the median eminence (341.4 fmol/mg of protein) [3].
Five products of the dynorphin gene--alpha-neo-endorphin, beta-neo-endorphin, dynorphin A, dynorphin A-(1-8), and dynorphin B--were measured in various regions of rat brain and in rat spinal cord and pituitary [4].
Similar changes were seen in the levels of other prodynorphin products, alpha- and beta-neo-endorphin (ir-alpha-nEnd and ir-beta-nEnd), and ir-[Leu5]enkephalin (ir-LE) [5].

Biological context of beta-neo-endorphin

Additionally, alpha- and beta-neo-endorphin can lower blood pressure in this model [6].
Beta-neo-endorphin, a new hypothalamic "big" Leu-enkephalin of porcine origin: its purification and the complete amino acid sequence [7].

Anatomical context of beta-neo-endorphin

Fractionation of Triton-solubilized rat brain membranes on diethylaminoethyl-cellulose resolves two peptidases which hydrolyze beta-neo-endorphin [8].
Leumorphin as well as beta-neo-endorphin and dynorphin inhibits the contraction of the rabbit vas deferens which is known to have only the kappa type opiate receptor [9].
The inhibitory action of leumorphin or beta-neo-endorphin on the contraction of the guinea pig ileum muscle strip was reduced in a dose-dependent manner by pretreatment with dynorphin and vice versa [9].

Associations of beta-neo-endorphin with other chemical compounds

The distribution of five major products of proenkephalin B [dynorphin1-17, dynorphin B, dynorphin1-8, alpha-neo-endorphin and beta-neo-endorphin] was studied in regions of rat brain and pituitary [10].
In the neurointermediate pituitary, the major immunoreactive components had the same chromatographic properties as synthetic dynorphin 1-17, dynorphin 1-8, dynorphin B, alpha- and beta-neo-endorphin, respectively, on gel filtration and high-performance liquid chromatography (HPLC) [11].

Gene context of beta-neo-endorphin

The structure of beta-neo-endorphin suggests that this opioid peptide is formed by the action of prolyl endopeptidase on a precursor of higher molecular weight [12].
Stimulation of prolactin secretion in the rat by alpha-neo-endorphin, beta-neo-endorphin and dynorphin [13].

Analytical, diagnostic and therapeutic context of beta-neo-endorphin

Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor [14].
These results suggest that the decrease in the ambulation induced by beta-neo-endorphin is not mediated by opioid receptors in the brain [15].

References

Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary. Lorenz, R.G., Evans, C.J., Barchas, J.D. Life Sci. (1985) [Pubmed]
Characterization of big dynorphins from rat brain and spinal cord. Xie, G.X., Goldstein, A. J. Neurosci. (1987) [Pubmed]
Distribution of immunoreactive beta-neo-endorphin in discrete areas of the rat brain and pituitary gland: comparison with alpha-neo-endorphin. Zamir, N., Palkovits, M., Brownstein, M.J. J. Neurosci. (1984) [Pubmed]
Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary. Cone, R.I., Weber, E., Barchas, J.D., Goldstein, A. J. Neurosci. (1983) [Pubmed]
Response of rat pituitary anterior lobe prodynorphin products to changes in gonadal steroid environment. Molineaux, C.J., Hassen, A.H., Rosenberger, J.G., Cox, B.M. Endocrinology (1986) [Pubmed]
Endogenous opioids and opiate antagonists modulate the blood pressure of the spontaneously hypertensive rat. Levin, E.R., Mills, S., Weber, M.A. Peptides (1986) [Pubmed]
Beta-neo-endorphin, a new hypothalamic "big" Leu-enkephalin of porcine origin: its purification and the complete amino acid sequence. Minamino, N., Kangawa, K., Chino, N., Sakakibara, S., Matsuo, H. Biochem. Biophys. Res. Commun. (1981) [Pubmed]
Degradation of alpha and beta neo-endorphin by rat brain membrane peptidases. Ulrich, C., Hersh, L.B. Peptides (1985) [Pubmed]
A novel opioid peptide, leumorphin, acts as an agonist at the kappa opiate receptor. Suda, M., Nakao, K., Yoshimasa, T., Ikeda, Y., Sakamoto, M., Yanaihara, N., Numa, S., Imura, H. Life Sci. (1983) [Pubmed]
Evidence for a selective processing of proenkephalin B into different opioid peptide forms in particular regions of rat brain and pituitary. Seizinger, B.R., Grimm, C., Höllt, V., Herz, A. J. Neurochem. (1984) [Pubmed]
Ontogenetic development of the pro-enkephalin B (= pro-dynorphin) opioid peptide system in the rat pituitary. Seizinger, B.R., Liebisch, D.C., Grimm, C., Herz, A. Neuroendocrinology (1984) [Pubmed]
Prolyl endopeptidase. Wilk, S. Life Sci. (1983) [Pubmed]
Stimulation of prolactin secretion in the rat by alpha-neo-endorphin, beta-neo-endorphin and dynorphin. Matsushita, N., Kato, Y., Shimatsu, A., Katakami, H., Fujino, M., Matsuo, H., Imura, H. Biochem. Biophys. Res. Commun. (1982) [Pubmed]
Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor. Kakidani, H., Furutani, Y., Takahashi, H., Noda, M., Morimoto, Y., Hirose, T., Asai, M., Inayama, S., Nakanishi, S., Numa, S. Nature (1982) [Pubmed]
Effects of beta-neo-endorphin on behaviors in mice using multi-dimensional behavioral analyses. Ukai, M., Kameyama, T. Peptides (1984) [Pubmed]

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