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Chemical Compound Review

AR-1J3471     (2S)-1-[(2S)-2-[[(2S)-6- amino-2-[[(2S)-2...

Synonyms: AC1L3U9V, 77739-21-0, beta-Neoendorphin, beta-neo-endorphin, Big leu-enkephalin, ...
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Disease relevance of beta-neo-endorphin


High impact information on beta-neo-endorphin


Biological context of beta-neo-endorphin


Anatomical context of beta-neo-endorphin

  • Fractionation of Triton-solubilized rat brain membranes on diethylaminoethyl-cellulose resolves two peptidases which hydrolyze beta-neo-endorphin [8].
  • Leumorphin as well as beta-neo-endorphin and dynorphin inhibits the contraction of the rabbit vas deferens which is known to have only the kappa type opiate receptor [9].
  • The inhibitory action of leumorphin or beta-neo-endorphin on the contraction of the guinea pig ileum muscle strip was reduced in a dose-dependent manner by pretreatment with dynorphin and vice versa [9].

Associations of beta-neo-endorphin with other chemical compounds


Gene context of beta-neo-endorphin


Analytical, diagnostic and therapeutic context of beta-neo-endorphin


  1. Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary. Lorenz, R.G., Evans, C.J., Barchas, J.D. Life Sci. (1985) [Pubmed]
  2. Characterization of big dynorphins from rat brain and spinal cord. Xie, G.X., Goldstein, A. J. Neurosci. (1987) [Pubmed]
  3. Distribution of immunoreactive beta-neo-endorphin in discrete areas of the rat brain and pituitary gland: comparison with alpha-neo-endorphin. Zamir, N., Palkovits, M., Brownstein, M.J. J. Neurosci. (1984) [Pubmed]
  4. Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary. Cone, R.I., Weber, E., Barchas, J.D., Goldstein, A. J. Neurosci. (1983) [Pubmed]
  5. Response of rat pituitary anterior lobe prodynorphin products to changes in gonadal steroid environment. Molineaux, C.J., Hassen, A.H., Rosenberger, J.G., Cox, B.M. Endocrinology (1986) [Pubmed]
  6. Endogenous opioids and opiate antagonists modulate the blood pressure of the spontaneously hypertensive rat. Levin, E.R., Mills, S., Weber, M.A. Peptides (1986) [Pubmed]
  7. Beta-neo-endorphin, a new hypothalamic "big" Leu-enkephalin of porcine origin: its purification and the complete amino acid sequence. Minamino, N., Kangawa, K., Chino, N., Sakakibara, S., Matsuo, H. Biochem. Biophys. Res. Commun. (1981) [Pubmed]
  8. Degradation of alpha and beta neo-endorphin by rat brain membrane peptidases. Ulrich, C., Hersh, L.B. Peptides (1985) [Pubmed]
  9. A novel opioid peptide, leumorphin, acts as an agonist at the kappa opiate receptor. Suda, M., Nakao, K., Yoshimasa, T., Ikeda, Y., Sakamoto, M., Yanaihara, N., Numa, S., Imura, H. Life Sci. (1983) [Pubmed]
  10. Evidence for a selective processing of proenkephalin B into different opioid peptide forms in particular regions of rat brain and pituitary. Seizinger, B.R., Grimm, C., Höllt, V., Herz, A. J. Neurochem. (1984) [Pubmed]
  11. Ontogenetic development of the pro-enkephalin B (= pro-dynorphin) opioid peptide system in the rat pituitary. Seizinger, B.R., Liebisch, D.C., Grimm, C., Herz, A. Neuroendocrinology (1984) [Pubmed]
  12. Prolyl endopeptidase. Wilk, S. Life Sci. (1983) [Pubmed]
  13. Stimulation of prolactin secretion in the rat by alpha-neo-endorphin, beta-neo-endorphin and dynorphin. Matsushita, N., Kato, Y., Shimatsu, A., Katakami, H., Fujino, M., Matsuo, H., Imura, H. Biochem. Biophys. Res. Commun. (1982) [Pubmed]
  14. Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor. Kakidani, H., Furutani, Y., Takahashi, H., Noda, M., Morimoto, Y., Hirose, T., Asai, M., Inayama, S., Nakanishi, S., Numa, S. Nature (1982) [Pubmed]
  15. Effects of beta-neo-endorphin on behaviors in mice using multi-dimensional behavioral analyses. Ukai, M., Kameyama, T. Peptides (1984) [Pubmed]
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