Gene Review:
PREP - prolyl endopeptidase
Homo sapiens
Synonyms:
PE, PEP, Post-proline cleaving enzyme, Prolyl endopeptidase
- Molecular cloning and characterization of prolyl endopeptidase from human T cells. Shirasawa, Y., Osawa, T., Hirashima, A. J. Biochem. (1994)
- Preclinical development of a recombinant toxin containing circularly permuted interleukin 4 and truncated Pseudomonas exotoxin for therapy of malignant astrocytoma. Puri, R.K., Hoon, D.S., Leland, P., Snoy, P., Rand, R.W., Pastan, I., Kreitman, R.J. Cancer Res. (1996)
- Neutral proteases in human osteoarthritic synovium. Martel-Pelletier, J., Cloutier, J.M., Pelletier, J.P. Arthritis Rheum. (1986)
- Rv1818c-encoded PE_PGRS protein of Mycobacterium tuberculosis is surface exposed and influences bacterial cell structure. Delogu, G., Pusceddu, C., Bua, A., Fadda, G., Brennan, M.J., Zanetti, S. Mol. Microbiol. (2004)
- Altered cell kinetics in cultured placental villous explants in pregnancies complicated by pre-eclampsia and intrauterine growth restriction. Crocker, I.P., Tansinda, D.M., Baker, P.N. J. Pathol. (2004)
- Effects of psychological stress on serum prolyl endopeptidase and dipeptidyl peptidase IV activity in humans: higher serum prolyl endopeptidase activity is related to stress-induced anxiety. Maes, M., Goossens, F., Lin, A., De Meester, I., Van Gastel, A., Scharpé, S. Psychoneuroendocrinology (1998)
- Novel proline endopeptidase inhibitors do not modify Abeta40/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein. Petit, A., Barelli, H., Morain, P., Checler, F. Br. J. Pharmacol. (2000)
- Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia. Maes, M., Libbrecht, I., Van Hunsel, F., Lin, A.H., Bonaccorso, S., Goossens, F., De Meester, I., De Clerck, L., Biondi, M., Scharpe, S., Janca, A. Psychological medicine. (1998)
- Left ventricular function during dynamic exercise in untrained and moderately trained subjects. Brandao, M.U., Wajngarten, M., Rondon, E., Giorgi, M.C., Hironaka, F., Negrao, C.E. J. Appl. Physiol. (1993)
- Bovine fibroblast growth factor: comparison of brain and pituitary preparations. Lemmon, S.K., Riley, M.C., Thomas, K.A., Hoover, G.A., Maciag, T., Bradshaw, R.A. J. Cell Biol. (1982)
- Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome. Jaeken, J., Martens, K., Francois, I., Eyskens, F., Lecointre, C., Derua, R., Meulemans, S., Slootstra, J.W., Waelkens, E., de Zegher, F., Creemers, J.W., Matthijs, G. Am. J. Hum. Genet. (2006)
- A human serine endopeptidase, purified with respect to activity against a peptide with phosphoserine in the P1' position, is apparently identical with prolyl endopeptidase. Rosén, J., Tomkinson, B., Pettersson, G., Zetterqvist, O. J. Biol. Chem. (1991)
- Vitamin E status of Chinese population in Taiwan. Chen, L.H., Hsu, S.J., Huang, C., Chen, J.S. Am. J. Clin. Nutr. (1977)
- Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy. Heinis, C., Alessi, P., Neri, D. Biochemistry (2004)
- Lower serum activity of prolyl endopeptidase in anorexia and bulimia nervosa. Maes, M., Monteleone, P., Bencivenga, R., Goossens, F., Maj, M., van West, D., Bosmans, E., Scharpe, S. Psychoneuroendocrinology (2001)
- Growth of urinary transitional cell carcinoma cell lines in agar, agarose and methyl cellulose. Flanigan, R.C., Pavlik, E.J., van Nagell, J.R., Keaton, K., Ragland, A., Kenady, D.E. J. Urol. (1985)
- TRH inactivation in the extracellular compartment: role of pyroglutamyl peptidase II. Charli, J.L., Vargas, M.A., Cisneros, M., de Gortari, P., Baeza, M.A., Jasso, P., Bourdais, J., Peréz, L., Uribe, R.M., Joseph-Bravo, P. Neurobiology (Budapest, Hungary) (1998)
- The prevalence and clinical significance of nocturnal hypertension in pregnancy. Brown, M.A., Davis, G.K., McHugh, L. J. Hypertens. (2001)
- Pyroglutamyl peptidase I and prolyl endopeptidase in human semen: increased activity in necrozoospermia. Valdivia, A., Irazusta, J., Fernández, D., Múgica, J., Ochoa, C., Casis, L. Regul. Pept. (2004)
- Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion. Schulz, I., Zeitschel, U., Rudolph, T., Ruiz-Carrillo, D., Rahfeld, J.U., Gerhartz, B., Bigl, V., Demuth, H.U., Rossner, S. J. Neurochem. (2005)
- Distribution of prolyl endopeptidase activities in rat and human brain. Irazusta, J., Larrinaga, G., González-Maeso, J., Gil, J., Meana, J.J., Casis, L. Neurochem. Int. (2002)
- Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain. Bellemère, G., Morain, P., Vaudry, H., Jégou, S. J. Neurochem. (2003)
- Cloning and sequence analysis of the gene encoding human lymphocyte prolyl endopeptidase. Vanhoof, G., Goossens, F., Hendriks, L., De Meester, I., Hendriks, D., Vriend, G., Van Broeckhoven, C., Scharpé, S. Gene (1994)
- Characterization of a prolyl endopeptidase (kininase) from human urine using fluorogenic quenched substrates. Quinto, B.M., Juliano, M.A., Hirata, I., Carmona, A.K., Juliano, L., Casarini, D.E. Int. J. Biochem. Cell Biol. (2000)
- Prolyl endopeptidase. Wilk, S. Life Sci. (1983)
- A prolyl endopeptidase-inhibiting antioxidant from Phyllanthus ussurensis. Chung, S.K., Nam, J.A., Jeon, S.Y., Kim, S.I., Lee, H.J., Chung, T.H., Song, K.S. Arch. Pharm. Res. (2003)
- Proteases in human lenses and their possible significance. Swanson, A.A., Davis, R.M., Meinhardt, N.C. Curr. Eye Res. (1985)
- Activity of dipeptidyl peptidase II and dipeptidyl peptidase IV in human gingiva with chronic marginal periodontitis. Mizutani, T., Mizutani, H., Kaneda, T., Hagihara, M., Nagatsu, T. Arch. Oral Biol. (1990)
- No genetic association of the human prolyl endopeptidase gene in the Dutch celiac disease population. Diosdado, B., Stepniak, D.T., Monsuur, A.J., Franke, L., Wapenaar, M.C., Mearin, M.L., Koning, F., Wijmenga, C. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- A Kazal prolyl endopeptidase inhibitor isolated from the skin of Phyllomedusa sauvagii. Gebhard, L.G., Carrizo, F.U., Stern, A.L., Burgardt, N.I., Faivovich, J., Lavilla, E., Ermácora, M.R. Eur. J. Biochem. (2004)
- Post-proline cleaving enzyme. Purification of this endopeptidase by affinity chromatography. Koida, M., Walter, R. J. Biol. Chem. (1976)
- Limited efficiency of prolyl-endopeptidase in the detoxification of gliadin peptides in celiac disease. Matysiak-Budnik, T., Candalh, C., Cellier, C., Dugave, C., Namane, A., Vidal-Martinez, T., Cerf-Bensussan, N., Heyman, M. Gastroenterology (2005)
- Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism. Lindqvist, P.G., Svensson, P.J., Dahlbäck, B., Marsál, K. Thromb. Haemost. (1998)
- Prothrombotic genotypes are not associated with pre-eclampsia and gestational hypertension: results from a large population-based study and systematic review. Morrison, E.R., Miedzybrodzka, Z.H., Campbell, D.M., Haites, N.E., Wilson, B.J., Watson, M.S., Greaves, M., Vickers, M.A. Thromb. Haemost. (2002)