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Chemical Compound Review

Xantidar     decasodium(2R,3S,4S,5R,6R)-3- [(2R,3R,4R...

Synonyms: LS-183150, AC1L3WZ1, IC 85158, SR 90107A, 114870-03-0, ...
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Gene context of

  • Furthermore, the dissociation constant between MCP-3 and Arixtra was determined by using electrospray ionization Fourier transform ion cyclotron resonance (ESI FT-ICR) mass spectrometry, which compared favorably with the result of the isothermal titration calorimetry (ITC) assay [16].
  • Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs [8].
  • Fondaparinux sodium, however, did not increase the LPS response [3].
  • Then she was treated with fondaparinux (Arixtra, Sanofi-Synthelabo, Paris, France) 2.5 mg daily for the remainder of the pregnancy [17].
  • At pH 8.4, SR 90107A/ORG 31540 was found to have a specific anti-factor Xa activity of 639 +/- 14 and 659 +/- 19 IU/mg (mean +/- sem, n = 6) when assayed in comparison with the 4th ISH and the Ist LMWHS respectively [18].

Analytical, diagnostic and therapeutic context of


  1. Fondaparinux sodium: a review of its use in the prevention of venous thromboembolism following major orthopaedic surgery. Reynolds, N.A., Perry, C.M., Scott, L.J. Drugs (2004) [Pubmed]
  2. Fondaparinux sodium. Keam, S.J., Goa, K.L. Drugs (2002) [Pubmed]
  3. Fondaparinux sodium lacks immunomodulatory effects of heparin. Heinzelmann, M., Bosshart, H. Am. J. Surg. (2004) [Pubmed]
  4. Efficacy of pentasaccharide on a prethrombosis model based on a calibrated stasis by the increase in up-stream venous pressure. Pottier, P., Planchon, B., Truchaud, F., Leftheriotis, G., Herbert, J.M., Bressollette, L., Passuti, N. Blood Coagul. Fibrinolysis (2003) [Pubmed]
  5. Fondaparinux (ARIXTRA) as an alternative anti-thrombotic prophylaxis when there is hypersensitivity to low molecular weight and unfractionated heparins. Parody, R., Oliver, A., Souto, J.C., Fontcuberta, J. Haematologica (2003) [Pubmed]
  6. Fondaparinux vs enoxaparin for the prevention of venous thromboembolism in major orthopedic surgery: a meta-analysis of 4 randomized double-blind studies. Turpie, A.G., Bauer, K.A., Eriksson, B.I., Lassen, M.R. Arch. Intern. Med. (2002) [Pubmed]
  7. Heterodimerization of CCR2 chemokines and regulation by glycosaminoglycan binding. Crown, S.E., Yu, Y., Sweeney, M.D., Leary, J.A., Handel, T.M. J. Biol. Chem. (2006) [Pubmed]
  8. Fondaparinux sodium is not metabolised in mammalian liver fractions and does not inhibit cytochrome P450-mediated metabolism of concomitant drugs. Lieu, C., Shi, J., Donat, F., Van Horn, R., Brian, W., Newton, J., Delbressine, L., Vos, R. Clinical pharmacokinetics. (2002) [Pubmed]
  9. The pharmacokinetics of fondaparinux sodium in healthy volunteers. Donat, F., Duret, J.P., Santoni, A., Cariou, R., Necciari, J., Magnani, H., de Greef, R. Clinical pharmacokinetics. (2002) [Pubmed]
  10. Fondaparinux sodium mechanism of action: identification of specific binding to purified and human plasma-derived proteins. Paolucci, F., Claviés, M.C., Donat, F., Necciari, J. Clinical pharmacokinetics. (2002) [Pubmed]
  11. Absence of interaction of fondaparinux sodium with aspirin and piroxicam in healthy male volunteers. Ollier, C., Faaij, R.A., Santoni, A., Duvauchelle, T., van Haard, P.M., Schoemaker, R.C., Cohen, A.F., de Greef, R., Burggraaf, J. Clinical pharmacokinetics. (2002) [Pubmed]
  12. Effects of anticoagulant treatment on intestinal ischaemia and reperfusion injury in rats. Olanders, K., Börjesson, A., Zhao, X., Andersson, R. Acta anaesthesiologica Scandinavica. (2005) [Pubmed]
  13. Clinical and experimental experience with factor Xa inhibitors. Viles-Gonzalez, J.F., Gaztanaga, J., Zafar, U.M., Fuster, V., Badimon, J.J. American journal of cardiovascular drugs : drugs, devices, and other interventions. (2004) [Pubmed]
  14. Effect of low molecular weight heparin (dalteparin) and fondaparinux (Arixtra) on human osteoblasts in vitro. Handschin, A.E., Trentz, O.A., Hoerstrup, S.P., Kock, H.J., Wanner, G.A., Trentz, O. The British journal of surgery. (2005) [Pubmed]
  15. Antagonism of SR 90107A/Org 31540-induced bleeding by protamine sulfate in rats and mice. Bernat, A., Hoffmann, P., Herbert, J.M. Thromb. Haemost. (1996) [Pubmed]
  16. Potential Inhibitors of Chemokine Function: Analysis of Noncovalent Complexes of CC Chemokine and Small Polyanionic Molecules by ESI FT-ICR Mass Spectrometry. Yu, Y., Sweeney, M.D., Saad, O.M., Leary, J.A. J. Am. Soc. Mass Spectrom. (2006) [Pubmed]
  17. Fondaparinux as anticoagulant in a pregnant woman with heparin allergy. Wijesiriwardana, A., Lees, D.A., Lush, C. Blood Coagul. Fibrinolysis (2006) [Pubmed]
  18. Determination of the anti-factor Xa activity of the synthetic pentasaccharide SR 90107A/ORG 31540 and of two structural analogues. Lormeau, J.C., Herault, J.P., Gaich, C., Barzu, T., van Dinther, T.G., Visser, A., Herbert, J.M. Thromb. Res. (1997) [Pubmed]
  19. Duration of prophylaxis against venous thromboembolism with fondaparinux after hip fracture surgery: a multicenter, randomized, placebo-controlled, double-blind study. Eriksson, B.I., Lassen, M.R. Arch. Intern. Med. (2003) [Pubmed]
  20. Fondaparinux for prevention of venous thromboembolism in major orthopedic surgery. Tran, A.H., Lee, G. The Annals of pharmacotherapy. (2003) [Pubmed]
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