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Gene Review

CCL7  -  chemokine (C-C motif) ligand 7

Homo sapiens

Synonyms: C-C motif chemokine 7, FIC, MARC, MCP-3, MCP3, ...
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Disease relevance of CCL7


Psychiatry related information on CCL7

  • The discussion is by Marc Schuckit, who was chair of the Substance Use disorders (SUD) Committee for DSM-IV and cochair of the international group of experts reviewing the SUD definitions for DSM-V [5].
  • He not only sent the 1836 memoir of Marc Dax, his deceased father, to Paris in 1863, but saw to it that this important document was published before Paul Broca's own article on cerebral dominance appeared later in 1865 [6].
  • Alzheimer's disease: how research is changing primary care management. Interview by Marc E. Weksler [7].

High impact information on CCL7


Chemical compound and disease context of CCL7


Biological context of CCL7


Anatomical context of CCL7


Associations of CCL7 with chemical compounds

  • We have isolated a cDNA (NC28) transcribed from a mRNA which is transiently induced in U937 promonocytic cells by PMA and super-induced by cycloheximide [21].
  • Pretreatment with actinomycin D abolished LAM-induced MCP-3 expression, whereas cycloheximide only partially reduced the expression [3].
  • MCP-1 and MCP-3 rapidly induced arachidonic acid release whereas MCP-2 was ineffective [22].
  • Furthermore, the dissociation constant between MCP-3 and Arixtra was determined by using electrospray ionization Fourier transform ion cyclotron resonance (ESI FT-ICR) mass spectrometry, which compared favorably with the result of the isothermal titration calorimetry (ITC) assay [23].
  • This allowed the detection of a change in intracellular Ca(2+) after treatment with CCL7 and Met-RANTES showing that these ligands possess measurable but low efficacy [24].

Physical interactions of CCL7

  • The transfectants (YT4/293) showed high affinity binding for 125I-MCP3 in addition to specifically binding 125I-MIP1 alpha and 125I-Rantes [16].
  • RANTES and MCP-3 antagonists bind multiple chemokine receptors [25].

Regulatory relationships of CCL7


Other interactions of CCL7

  • MCP3, MIP1 alpha, and Rantes were equally able to cross-attenuate the migratory response of YT4/293 cells to one another [16].
  • In this study, we have examined potential interactions of MCP-2 and MCP-3 with the recently cloned MCP-1 receptor [19].
  • In contrast, responses to MCP-3 were blocked only in the presence of both mAbs, but not after pretreatment with either anti-CCR2 or anti-CCR3 mAb alone [28].
  • MCP3 in our study was also the only human CC chemokine that consistently chemoattracted neutrophils [20].
  • Bacteria-induced CCL2, CCL7, CXCL9, and CXCL10 mRNA expression was partially dependent on ongoing protein synthesis [29].

Analytical, diagnostic and therapeutic context of CCL7


  1. Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia. Choi, E.S., Jakubzick, C., Carpenter, K.J., Kunkel, S.L., Evanoff, H., Martinez, F.J., Flaherty, K.R., Toews, G.B., Colby, T.V., Kazerooni, E.A., Gross, B.H., Travis, W.D., Hogaboam, C.M. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  2. MCP-1-MCP-3-Eotaxin gene cluster influences HIV-1 transmission. Modi, W.S., Goedert, J.J., Strathdee, S., Buchbinder, S., Detels, R., Donfield, S., O'Brien, S.J., Winkler, C. AIDS (2003) [Pubmed]
  3. Expression of monocyte chemotactic protein-3 in human monocytes exposed to the mycobacterial cell wall component lipoarabinomannan. Vouret-Craviari, V., Cenzuales, S., Poli, G., Mantovani, A. Cytokine (1997) [Pubmed]
  4. MCP-3 (CCL7) delivered by parvovirus MVMp reduces tumorigenicity of mouse melanoma cells through activation of T lymphocytes and NK cells. Wetzel, K., Struyf, S., Van Damme, J., Kayser, T., Vecchi, A., Sozzani, S., Rommelaere, J., Cornelis, J.J., Dinsart, C. Int. J. Cancer (2007) [Pubmed]
  5. Should DSM-V include dimensional diagnostic criteria for alcohol use disorders? Helzer, J.E., Bucholz, K.K., Bierut, L.J., Regier, D.A., Schuckit, M.A., Guth, S.E. Alcohol. Clin. Exp. Res. (2006) [Pubmed]
  6. Does Gustave Dax deserve to be forgotten? The temporal lobe theory and other contributions of an overlooked figure in the history of language and cerebral dominance. Finger, S., Roe, D. Brain and language. (1999) [Pubmed]
  7. Alzheimer's disease: how research is changing primary care management. Interview by Marc E. Weksler. marotta, C. Geriatrics. (1994) [Pubmed]
  8. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. McQuibban, G.A., Gong, J.H., Tam, E.M., McCulloch, C.A., Clark-Lewis, I., Overall, C.M. Science (2000) [Pubmed]
  9. Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin. Uguccioni, M., Loetscher, P., Forssmann, U., Dewald, B., Li, H., Lima, S.H., Li, Y., Kreider, B., Garotta, G., Thelen, M., Baggiolini, M. J. Exp. Med. (1996) [Pubmed]
  10. Temocillin. In vitro antibacterial activity. Slocombe, B., Cooper, C.E., Griffin, K.E., White, A.R. Drugs (1985) [Pubmed]
  11. Serum levels of monocyte chemotactic protein-3/CCL7 are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis. Yanaba, K., Komura, K., Kodera, M., Matsushita, T., Hasegawa, M., Takehara, K., Sato, S. Ann. Rheum. Dis. (2006) [Pubmed]
  12. In-vitro evaluation of clarithromycin, temafloxacin, and ethambutol in combination against Mycobacterium avium complex. Gevaudan, M.J., Bollet, C., Mallet, M.N., de Micco, P. J. Antimicrob. Chemother. (1993) [Pubmed]
  13. Oral administration of beta-cryptoxanthin prevents bone loss in ovariectomized rats. Uchiyama, S., Yamaguchi, M. Int. J. Mol. Med. (2006) [Pubmed]
  14. Evaluation of in vitro interaction of daptomycin with gentamicin or beta-lactam antibiotics against Staphylococcus aureus and Enterococci by FIC index and timed-kill curves. Snydman, D.R., McDermott, L.A., Jacobus, N.V. Journal of chemotherapy (Florence, Italy) (2005) [Pubmed]
  15. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines. Uguccioni, M., Mackay, C.R., Ochensberger, B., Loetscher, P., Rhis, S., LaRosa, G.J., Rao, P., Ponath, P.D., Baggiolini, M., Dahinden, C.A. J. Clin. Invest. (1997) [Pubmed]
  16. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3. Ben-Baruch, A., Xu, L., Young, P.R., Bengali, K., Oppenheim, J.J., Wang, J.M. J. Biol. Chem. (1995) [Pubmed]
  17. Synergy between proinflammatory ligands of G protein-coupled receptors in neutrophil activation and migration. Gouwy, M., Struyf, S., Catusse, J., Proost, P., Van Damme, J. J. Leukoc. Biol. (2004) [Pubmed]
  18. Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine. Dahinden, C.A., Geiser, T., Brunner, T., von Tscharner, V., Caput, D., Ferrara, P., Minty, A., Baggiolini, M. J. Exp. Med. (1994) [Pubmed]
  19. Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor. Franci, C., Wong, L.M., Van Damme, J., Proost, P., Charo, I.F. J. Immunol. (1995) [Pubmed]
  20. Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors: binding and signaling of MCP3 through shared as well as unique receptors on monocytes and neutrophils. Xu, L.L., McVicar, D.W., Ben-Baruch, A., Kuhns, D.B., Johnston, J., Oppenheim, J.J., Wang, J.M. Eur. J. Immunol. (1995) [Pubmed]
  21. Molecular cloning of the MCP-3 chemokine gene and regulation of its expression. Minty, A., Chalon, P., Guillemot, J.C., Kaghad, M., Liauzun, P., Magazin, M., Miloux, B., Minty, C., Ramond, P., Vita, N. Eur. Cytokine Netw. (1993) [Pubmed]
  22. Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. Sozzani, S., Zhou, D., Locati, M., Rieppi, M., Proost, P., Magazin, M., Vita, N., van Damme, J., Mantovani, A. J. Immunol. (1994) [Pubmed]
  23. Potential Inhibitors of Chemokine Function: Analysis of Noncovalent Complexes of CC Chemokine and Small Polyanionic Molecules by ESI FT-ICR Mass Spectrometry. Yu, Y., Sweeney, M.D., Saad, O.M., Leary, J.A. J. Am. Soc. Mass Spectrom. (2006) [Pubmed]
  24. Diverse signalling by different chemokines through the chemokine receptor CCR5. Mueller, A., Mahmoud, N.G., Strange, P.G. Biochem. Pharmacol. (2006) [Pubmed]
  25. RANTES and MCP-3 antagonists bind multiple chemokine receptors. Gong, J.H., Uguccioni, M., Dewald, B., Baggiolini, M., Clark-Lewis, I. J. Biol. Chem. (1996) [Pubmed]
  26. Microsatellite polymorphisms in the gene promoter of monocyte chemotactic protein-3 and analysis of the association between monocyte chemotactic protein-3 alleles and multiple sclerosis development. Fiten, P., Vandenbroeck, K., Dubois, B., Van Coillie, E., Nelissen, I., Van Damme, J., Ligers, A., Hillert, J., Andersson, M., Olsson, T., Opdenakker, G. J. Neuroimmunol. (1999) [Pubmed]
  27. Structural and functional analysis of the promoter region of the human MCP-3 gene: transactivation of expression by novel recognition sequences adjacent to the transcription initiation site. Murakami, K., Nomiyama, H., Miura, R., Follens, A., Fiten, P., Van Coillie, E., Van Damme, J., Opdenakker, G. DNA Cell Biol. (1997) [Pubmed]
  28. Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling. Heinemann, A., Hartnell, A., Stubbs, V.E., Murakami, K., Soler, D., LaRosa, G., Askenase, P.W., Williams, T.J., Sabroe, I. J. Immunol. (2000) [Pubmed]
  29. Lactobacilli and streptococci induce inflammatory chemokine production in human macrophages that stimulates Th1 cell chemotaxis. Veckman, V., Miettinen, M., Matikainen, S., Lande, R., Giacomini, E., Coccia, E.M., Julkunen, I. J. Leukoc. Biol. (2003) [Pubmed]
  30. Up-regulation of interleukin-8, interleukin-10, monocyte chemotactic protein-1, and monocyte chemotactic protein-3 in peripheral blood monocytes in stable lung transplant recipients: are immunosuppression regimens working? Hodge, G., Hodge, S., Reynolds, P.N., Holmes, M. Transplantation (2005) [Pubmed]
  31. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. Berkhout, T.A., Sarau, H.M., Moores, K., White, J.R., Elshourbagy, N., Appelbaum, E., Reape, R.J., Brawner, M., Makwana, J., Foley, J.J., Schmidt, D.B., Imburgia, C., McNulty, D., Matthews, J., O'Donnell, K., O'Shannessy, D., Scott, M., Groot, P.H., Macphee, C. J. Biol. Chem. (1997) [Pubmed]
  32. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. Opdenakker, G., Froyen, G., Fiten, P., Proost, P., Van Damme, J. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
  33. The kinetics of allergen-induced transcription of messenger RNA for monocyte chemotactic protein-3 and RANTES in the skin of human atopic subjects: relationship to eosinophil, T cell, and macrophage recruitment. Ying, S., Taborda-Barata, L., Meng, Q., Humbert, M., Kay, A.B. J. Exp. Med. (1995) [Pubmed]
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