Disease relevance of Glucoenergan

• 1. The effects produced by discontinuation of long-term treatment with fencamfamine (FCF) were evaluated recording behavioral and body weight changes [1].

Psychiatry related information on Glucoenergan

• Amphetamine, mazindol, and fencamfamin in narcolepsy [2].
• Effect of apomorphine on rat motor activity induced by fencamfamine and other indirect psychostimulant drugs [3].
• The effects of fencamfamine (25 and 50 mg po) were studied on acute psychophysiological and psychomotor performance in six healthy male volunteers [4].
• On acute effects of some drugs on the higher nervous activity in man. Benzoctamine (10 mg), sodium hydroxybutyrate (2 g), fencamfamine (10 mg) [5].

High impact information on Glucoenergan

• Using in vivo microdialysis, the caudate and nucleus accumbens dopamine (DA) responses to the psychomotor stimulants amphetamine (AMPH), cocaine (COC), and fencamfamine (FCF) were evaluated in rats concurrent with characterization of their behavioral response profiles [6].
• It is concluded that, at least in the models employed, the in vitro profile of fencamfamine is more similar to that of nomifensine, a reportedly pure uptake inhibitor, than to d-amphetamine [7].
• Furthermore, the activity of fencamfamine on biogenic amine uptake in synaptosome preparations and on monoamine oxidase activity was evaluated [7].
• To elucidate its mechanism of action, the effects of fencamfamine, a norcamphanethylamine derivative, were studied in vitro on the release of newly accumulated dopamine in superfusion experiments using slices of rat corpus striatum and substantia nigra in comparison to nomifensine and d-amphetamine [7].
• Catheterized beagle dogs were given access to response-contingent intravenous injections of fencamfamine (FEN) or cocaine (COC) injections under a fixed-ratio (FR) schedule of reinforcement [8].

Biological context of Glucoenergan

• After enzymatic hydrolysis of the urine the major human metabolite, N-desethylated fencamfamine, only accounted for 1% of the dose in 12 h [9].
• Reduction of food intake by fencamfamine in rats [10].
• Fencamfamine showed low affinity for binding sites of [3H]haloperidol and [3H]dihydroergocriptine [11].
• Stimulant effects, such as greater increases of critical flicker-fusion threshold, heart rate, blood pressure and stimulation assessed by self-rating, were more pronounced with the higher dose of fencamfamine [4].

Anatomical context of Glucoenergan

• A gas chromatographic method to measure urinary levels of the central nervous system stimulant fencamfamine and some of its metabolites is described [9].

Analytical, diagnostic and therapeutic context of Glucoenergan

• Intravenous self-administration of fencamfamine and cocaine by beagle dogs under fixed-ratio and progressive-ratio schedules of reinforcement [8].
• Disposition of human drug preparations in the horse. II. Orally administered fencamfamine [9].
• The renal excretion of fencamfamine and its metabolite after oral administration to humans was followed over a period of several days [12].

References