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Chemical Compound Review

Caustic soda     sodium hydroxide

Synonyms: Ascarite, Rohrputz, Aetznatron, Plung, NaOH, ...
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Disease relevance of sodium hydroxide


High impact information on sodium hydroxide

  • Hexa- and decapeptides have been identified with sequence homologies that define four motifs: 1, (E)TPXWM/LM/L; 2, W/YXWM/ LYE; 3, DWXDW; and 4, (Ar)WDGQ(Ar) [5].
  • We analyze the effects of concentration and time of contact on the aggressiveness of CS to the esophagus of live animals [6].
  • However, the interdependence of these factors in the production of caustic lesion in the esophageal mucosa is not known, especially regarding CS as the strongest corrosive agent [6].
  • The transmucosal fluxes of Na+ and Cl- were studied in Giardia lamblia-infected mice in the presence or absence of dantrolene (1-(5(p-nitrophenyl)furfurilidene-amino) hydantoin sodium hydrate) [7].
  • We evaluated whether pretreatment with sivelestat sodium hydrate, a neutrophil elastase inhibitor (EI), can prevent acute lung injury caused by CPB [8].

Anatomical context of sodium hydroxide


Associations of sodium hydroxide with other chemical compounds

  • I have tested the idea that doubly labeled water (DLW) can accurately predict CO2 production in savannah sparrows, song sparrows, white-throated sparrows, starlings, and a single house sparrow by comparing DLW estimates with those obtained simultaneously by capturing expired CO2 in Ascarite [11].

Analytical, diagnostic and therapeutic context of sodium hydroxide

  • The analytical system consisted sequentially of a He-sparging bottle of water, a gas dryer, CO(2)-trapping stage using both Ascarite trap and silica-gel packed gas chromatography (GC), on-line oxidation to CO(2) using the Schütze reagent, cryofocusing, GC purification using a capillary column and measurement by CF-IRMS [12].


  1. Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters. Iba, T., Kidokoro, A., Fukunaga, M., Takuhiro, K., Yoshikawa, S., Sugimotoa, K. Shock (2006) [Pubmed]
  2. Relationship between neutrophil elastase and acute lung injury in humans. Tamakuma, S., Ogawa, M., Aikawa, N., Kubota, T., Hirasawa, H., Ishizaka, A., Taenaka, N., Hamada, C., Matsuoka, S., Abiru, T. Pulmonary pharmacology & therapeutics. (2004) [Pubmed]
  3. Effect of simulated spray chilling with chemical solutions on acid-habituated and non-acid-habituated Escherichia coli O157:H7 cells attached to beef carcass tissue. Stopforth, J.D., Yoon, Y., Belk, K.E., Scanga, J.A., Kendall, P.A., Smith, G.C., Sofos, J.N. J. Food Prot. (2004) [Pubmed]
  4. Acute respiratory failure associated with miliary tuberculosis successfully treated with sivelestat sodium hydrate. Utsugi, M., Ishizuka, T., Hisada, T., Shimizu, Y., Dobashi, K., Mori, M. Intern. Med. (2006) [Pubmed]
  5. Peptide libraries define the fine specificity of anti-polysaccharide antibodies to Cryptococcus neoformans. Valadon, P., Nussbaum, G., Boyd, L.F., Margulies, D.H., Scharff, M.D. J. Mol. Biol. (1996) [Pubmed]
  6. Effects of time of contact and concentration of caustic agent on generation of injuries. Mattos, G.M., Lopes, D.D., Mamede, R.C., Ricz, H., Mello-Filho, F.V., Neto, J.B. Laryngoscope (2006) [Pubmed]
  7. Involvement of intracellular calcium stores in Giardia lamblia induced diarrhoea in mice. Gorowara, S., Ganguly, N.K., Mahajan, R.C., Walia, B.N. FEMS Microbiol. Lett. (1994) [Pubmed]
  8. Neutrophil elastase inhibitor, sivelestat, attenuates acute lung injury after cardiopulmonary bypass in the rabbit endotoxemia model. Wakayama, F., Fukuda, I., Suzuki, Y., Kondo, N. Ann. Thorac. Surg. (2007) [Pubmed]
  9. Rapid penetration of lucifer yellow into vital teeth and dye coupling between odontoblasts and neighbouring pulp cells in the cat. Ikeda, H., Suda, H. Arch. Oral Biol. (2006) [Pubmed]
  10. Virus Associated Hemophagocytic Syndrome Accompanied by Acute Respiratory Failure Caused by Influenza A (H3N2). Ando, M., Miyazaki, E., Hiroshige, S., Ashihara, Y., Okubo, T., Ueo, M., Fukami, T., Sugisaki, K., Tsuda, T., Ohishi, K., Yoshitake, S., Noguchi, T., Kumamoto, T. Intern. Med. (2006) [Pubmed]
  11. Validation of the doubly labeled water technique for measuring energy metabolism in starlings and sparrows. Williams, J.B. Comparative biochemistry and physiology. A, Comparative physiology. (1985) [Pubmed]
  12. Stable carbon and oxygen isotopic analysis of carbon monoxide in natural waters. Tsunogai, U., Nakagawa, F., Hachisu, Y., Yoshida, N. Rapid Commun. Mass Spectrom. (2000) [Pubmed]
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