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Chemical Compound Review

H4-biopterin     5,6,7,8-tetrahydropteridine

Synonyms: AG-K-74325, SureCN1448583, CHEBI:28889, HMDB01216, KST-1A9778, ...
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Disease relevance of tetrahydropteridine

  • Moreover, those tumor cells that were more resistant to ALP cytotoxicity (pleomorphic glioma, 78-FR-G-219/S4) had a 3-fold higher tetrahydropteridine-dependent cleavage activity than a more cytotoxic sensitive line (astrocytoma cells, 78-FR-G-299) [1].
  • Comparison of the microsomal activities of the tetrahydropteridine-dependent alkyl-cleavage enzyme present in astrocytoma 78-FR-G-299 cells and the pleomorphic glioma 78-FR-G-219/S4 cells to that found in normal skin fibroblasts and rat livers revealed a markedly reduced activity in the neoplastic cell lines [1].

High impact information on tetrahydropteridine


Anatomical context of tetrahydropteridine


Associations of tetrahydropteridine with other chemical compounds


Gene context of tetrahydropteridine


  1. Cytotoxicity of alkyl-lysophospholipid derivatives and low-alkyl-cleavage enzyme activities in rat brain tumor cells. Berdel, W.E., Greiner, E., Fink, U., Stavrou, D., Reichert, A., Rastetter, J., Hoffman, D.R., Snyder, F. Cancer Res. (1983) [Pubmed]
  2. Activation and nuclear translocation of protein kinase during transsynaptic induction of tyrosine 3-monooxygenase. Costa, E., Kurosawa, A., Guidotti, A. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  3. Evidence for the formation of the 4a-carbinolamine during the tyrosine-dependent oxidation of tetrahydrobiopterin by rat liver phenylalanine hydroxylase. Davis, M.D., Kaufman, S. J. Biol. Chem. (1989) [Pubmed]
  4. Studies on the phenylalanine hydroxylase system in vivo. An in vivo assay based on the liberation of deuterium or tritium into the body water from ring-labeled L-phenylalanine. Milstien, S., Kaufman, S. J. Biol. Chem. (1975) [Pubmed]
  5. Tetrahydropteridines suppress gene expression and induce apoptosis of activated RAW264.7 cells via formation of hydrogen peroxide. Thoeni, G., Werner, E.R., Werner-Felmayer, G. Free Radic. Biol. Med. (2004) [Pubmed]
  6. Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase. Edelman, A.M., Raese, J.D., Lazar, M.A., Barchas, J.D. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  7. N-methyl-norsalsolinol, an endogenous neurotoxin, inhibits tyrosine hydroxylase activity in the rat brain nucleus accumbens in vitro. Scholz, J., Bamberg, H., Moser, A. Neurochem. Int. (1997) [Pubmed]
  8. Tryptophan 5-hydroxylase. Rapid purification from whole rat brain and production of a specific antiserum. Cash, C.D., Vayer, P., Mandel, P., Maitre, M. Eur. J. Biochem. (1985) [Pubmed]
  9. The effect of 6-aminonicotinamide blockade of the pentose phosphate pathway on catecholamines in the rat adrenal medulla, superior cervical ganglion, hypothalamus and synaptosome fractions. Jansson, S.E., Gripenberg, J., Härkönen, M. Acta Physiol. Scand. (1977) [Pubmed]
  10. Developmental regulation of phenylalanine hydroxylase activity in Drosophila melanogaster. Geltosky, J.E., Mitchell, H.K. Biochem. Genet. (1980) [Pubmed]
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