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Gene Review

Hn  -  Henna

Drosophila melanogaster

Synonyms: CG7399, DTPH, Dmel\CG7399, PAH, Pah, ...
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High impact information on Hn


Biological context of Hn


Anatomical context of Hn


Associations of Hn with chemical compounds


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Analytical, diagnostic and therapeutic context of Hn

  • Demonstration of this CRM as the PAH protein comes from the correlation between the decreased PAH enzyme activities of two mutant strains and their decreased amounts of CRM by Western blotting [11].


  1. A single locus encodes both phenylalanine hydroxylase and tryptophan hydroxylase activities in Drosophila. Neckameyer, W.S., White, K. J. Biol. Chem. (1992) [Pubmed]
  2. Xanthurenic acid 8-O-beta-D-glucoside, a novel tryptophan metabolite in eye-color mutants of Drosophila melanogaster. Ferré, J., Real, M.D., Ménsua, J.L., Jacobson, K.B. J. Biol. Chem. (1985) [Pubmed]
  3. Sequence and expression of the Drosophila phenylalanine hydroxylase mRNA. Morales, G., Requena, J.M., Jimenez-Ruiz, A., Lopez, M.C., Ugarte, M., Alonso, C. Gene (1990) [Pubmed]
  4. Structure of the phenylalanine hydroxylase gene in Drosophila melanogaster and evidence of alternative promoter usage. Ruiz-Vázquez, P., Moulard, M., Silva, F.J. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  5. Aberrant splicing of the Drosophila melanogaster phenylalanine hydroxylase pre-mRNA caused by the insertion of a B104/roo transposable element in the Henna locus. Ruiz-Vázquez, P., Silva, F.J. Insect Biochem. Mol. Biol. (1999) [Pubmed]
  6. A genetic analysis of aromatic amino acid hydroxylases involvement in DOPA synthesis during Drosophila adult development. Piedrafita, A.C., Martínez-Ramírez, A.C., Silva, F.J. Insect Biochem. Mol. Biol. (1994) [Pubmed]
  7. Substrate regulation of serotonin and dopamine synthesis in Drosophila. Coleman, C.M., Neckameyer, W.S. Invert. Neurosci. (2004) [Pubmed]
  8. Fluid secretion by isolated Malpighian tubules of Drosophila melanogaster Meig.: effects of organic anions, quinacrine and a diuretic factor found in the secreted fluid. Riegel, J.A., Farndale, R.W., Maddrell, S.H. J. Exp. Biol. (1999) [Pubmed]
  9. Candidate target mechanisms of the growth inhibitor cyromazine: studies of phenylalanine hydroxylase, puparial amino acids, and dihydrofolate reductase in dipteran insects. Bel, Y., Wiesner, P., Kayser, H. Arch. Insect Biochem. Physiol. (2000) [Pubmed]
  10. An assessment of the genotoxicity of 2-hydroxy-1,4-naphthoquinone, the natural dye ingredient of Henna. Kirkland, D., Marzin, D. Mutat. Res. (2003) [Pubmed]
  11. Immunological detection of phenylalanine hydroxylase protein in Drosophila melanogaster. Silva, F.J., Bel, Y., Botella, L.M., Cotton, R.G., Ferré, J. Biochem. J. (1992) [Pubmed]
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