Disease relevance of Myristate

• For a series of model compounds (digitonin, aescine, tomatine, stevioside and ginsenoside Rg1) it was demonstrated that neither the surface nor the interfacial tension (n-decane/water) lowering properties of saponins can be correlated with their ability to induce hemolysis [1].

High impact information on Myristate

• We report a new route for forming reverse wormlike micelles (i.e., long, flexible micellar chains) in nonpolar organic liquids such as cyclohexane and n-decane [2].
• We have discovered that samples of poly(ferrocenyldimethylsilane-b-dimethylsiloxane) (PFS-b-PDMS) with block ratios of 1:12 form nanotubes in n-hexane and n-decane, which are poor solvents for PFS [3].
• Acylation of gramicidin A does not affect the single-channel conductance or the minichannel frequency in diphytanoylphosphatidylcholine/n-decane black lipid membranes [4].
• For example, the morphine stereoisomer alpha-isomorphine, the geometric isomer B/C trans-morphine, and the 8-position-substituted gamma-isomorphine were successes in the n-decane condition, whereas the ethanol condition produced the substituted codeine derivatives dihydrocodeinone and dihydroxycodeinone [5].
• This mutation inactivated the ability of PAT1 to complement the defective n-decane utilization of the disruptant [6].

Biological context of Myristate

• Cloning and characterization of an n-alkane-inducible cytochrome P450 gene essential for n-decane assimilation by Yarrowia lipolytica [7].
• The differential effects of inducers (phenobarbital and clofibrate) and inhibitors (sodium laurate, n-decane, metyrapone) on terminal and subterminal hydroxylation as well as differences in apparent Km for the two suggest that rat liver contains at least two different MEHP hydroxylases [8].
• In the presence of n-decane, the IC(50) values on cell growth were approximately 1-5 microM for SQMG and about 0.3-1 microM for SQDG [9].
• Growth of some strains was retarded by the presence of n-decane but reached to the same cell densities at late stationary phase [10].

Anatomical context of Myristate

• Less information was accessible for membranes containing n-decane within their structure [11].
• Both B0-6-1 and a null mutant of YlPEX10 failed to form peroxisome and showed low-level transcription of YlALK1 after the change of carbon source to n-decane [12].

Associations of Myristate with other chemical compounds

• Changes in the tension of GMO/n-decane membranes induced by altering the composition of the parent solution were detected and quantified [13].
• The method was used to determine the partition ratio of iodochlorhydroxyquin between n-decane and phosphate-buffered saline, pH 7 [14].
• The assay involves derivatization with pentafluorobenzyl bromide and extraction into n-decane, followed by gas chromatography-mass spectrometry [15].
• At the tips of two syringes, large spherical model membranes have been made from phosphatidylcholine and varying amounts of mixed brain gangliosides dissolved in n-decane [16].
• The dynamic IFTs between alkylnaphthalene sulfonates with different alkyl chain length and n-decane, oleic acid model oil, or Shengli crude oil were measured [17].

Gene context of Myristate

• Isolation and characterization of acetoacetyl-CoA thiolase gene essential for n-decane assimilation in yeast Yarrowia lipolytica [6].
• The value of intermonolayer viscosity, etar, for membranes formed from azolectin mixed with lysophosphatidylcholine (7.10(-4) mg/ml) in n-decane, etar approximately 10(-9) g/s, was determined from comparison of the theoretical calculations and literature data [18].

Analytical, diagnostic and therapeutic context of Myristate

• The n-alkane dehydrogenase (fraction R-3), obtained as a single peak from Bio-Gel P-60, showed an overall 135-fold purification and was demonstrated by infrared spectroscopy and gas chromatography to convert n-decane to 1-decene [19].
• The second monolayer consisting of phospholipids was then deposited onto this hydrophobic surface by (i) the Langmuir-Schaefer-technique, (ii) from lipid solution in n-decane/isobutanol, (iii) by the lipid/detergent dilution technique or (iv) by fusion of vesicles [20].

References