Disease relevance of Ioglycamic Acid

• Intravenous injection of the divalent X-ray contrast medium ioglycamic acid ("Biligram") induced intravascular precipitation and sudden death of a patient owing to reaction with his monoclonal macroglobulin [1].
• Thyroid function was studied for 42 days in 58 patients, 28 of whome had euthyroid goiter, after urography (diatrizoic acid), cholangiography (ioglycamic acid), and cholecystography (Naiopanoate) [2].
• In 18 patients 131I Biligram was found to be unsatifactory for differentiating parenchymal liver disease from biliary tract obstruction owing to inability to demonstrate the gallbladder when liver function was more than mildly deranged [3].
• Fifty-five anicteric patients with acute upper abdominal pain were examined with low-dose drip-infusion cholangiography using ioglycamide acid (17 ml Bilivistan, 280 mg I/ml) given over two hours [4].

High impact information on Ioglycamic Acid

• Inhalation bronchography using powdered calcium ioglycamic acid [5].
• Biotransformation of ioglycamic acid, iodoxamic acid and iotroxic acid in man [6].
• Sol-jell convertion and/or turbidimetric variations have not been observed when either sera or plasmas have been mixed with variable amounts of a methylglucamine salt of ioglycamic acid (MGI) and other compounds [7].
• Relation between renal and hepatic excretion of drugs. XIV. Elimination of ioglycamic acid after nephrectomy, bile duct ligation, and after treatment with hormones or xenobiotics in young and adult rats [8].
• Meglumine ioglycamide (Biligram: Schering) alone, the strongly protein-binding agent, exhibited the phenomenon, and only in high concentration [9].

Biological context of Ioglycamic Acid

• In 16 baboons, reproducible bronchograms could be achieved by inhalation of 400--800 mg of powdered calcium ioglycamic acid [5].

Anatomical context of Ioglycamic Acid

• Iodine-131 labelled Biligram has been evaluated as a radiopharmaceutical for dynamic scintiscanning of the liver and biliary tract [3].
• Ioglycamide (Biligram) studies in man. Radiological opacification of the bile duct. A comparison of a number of different methods [10].

Associations of Ioglycamic Acid with other chemical compounds

• With the use of an aqueous two-phase system the effect of ioglycamide (Bilivistan) on the binding of testosterone and estradiol to albumin and testosterone-estradiol-binding globulin was investigated using whole human serum [11].

Analytical, diagnostic and therapeutic context of Ioglycamic Acid

• Eleven patients were given an intravenous infusion of the biliary contrast agent ioglycamide (Biligram), while the other 10 acted as controls [12].

References