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Chemical Compound Review

Hypaque     3,5-diacetamido-2,4,6- triiodo-benzoic acid

Synonyms: Odiston, Triombrin, DIATRIZOATE, Iothalamate, Gastrografin, ...
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Disease relevance of amidotrizoic acid


High impact information on amidotrizoic acid


Chemical compound and disease context of amidotrizoic acid


Biological context of amidotrizoic acid


Anatomical context of amidotrizoic acid


Associations of amidotrizoic acid with other chemical compounds


Gene context of amidotrizoic acid

  • CONCLUSION: Intravenous injection of ionic high-osmolar diatrizoate reduced renal GPX activity during the first hour in both normal and STZ-induced diabetic rats [30].
  • The two CM induced an immediate and progressive decline of both GFR and RPF in the absence of hypovolemia, more pronounced in D (-36% at 120 min) than after I (-19% at 120 min; P < 0.05 versus D) [16].
  • In unpretreated patients receiving either D or I, plasma ET-1 did not change but urinary levels increased; these changes were, however, dissociated from those observed in renal hemodynamics [16].
  • To discover the agents in the medium causing the cytogenetic damage, we exposed human lymphocyte cultures to diatrizoate and to the monoamino- and diamino-derivatives of triiodobenzoic acid [31].
  • NO generation was implicated in the actions of several nephrotoxicants, i.e., diatrizoate, gentamicin, amikacin, HgCl(2), and CdCl(2), each of which decreased Mrp2-mediated transport by activating ET signaling [32].

Analytical, diagnostic and therapeutic context of amidotrizoic acid


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  34. Hemodynamic changes induced by cardiac angiography with ioxaglate: comparison with diatrizoate. Hirshfeld, J.W., Laskey, W., Martin, J.L., Groh, W.C., Untereker, W., Wolf, G.L. J. Am. Coll. Cardiol. (1983) [Pubmed]
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