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Chemical Compound Review

SureCN563218     4-[2-(3,5- dimethoxyphenyl)ethenyl]phenol

Synonyms: AG-J-74395, ANW-44904, AC1L4NRG, CTK6J5760, IN1155, ...
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Disease relevance of C10287


High impact information on C10287

  • Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells [1].
  • Of note, pterostilbene-induced apoptosis was not inhibited by the pancaspase-inhibitor Z-VAD-fmk, suggesting that this compound acts through a caspase-independent pathway [1].
  • Moreover, pterostilbene and 3'-hydroxypterostilbene, when used at concentrations that elicit significant apoptotic effects in tumor cell lines, did not show any cytotoxicity in normal hemopoietic stem cells [1].
  • The antioxidant activity of the cis and trans isomers of several analogues of resveratrol and pterostilbene has been investigated, especially with regard to the effect of the stereochemistry about the olefinic double bond [4].
  • Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers [5].

Biological context of C10287

  • The increased levels of lipid peroxidation measured as thiobarbituric acid reactive substances (TBARS) in liver and kidney of diabetic rats were also normalized by treatment with pterostilbene [2].
  • The assay was applied successfully to the study of pterostilbene pharmacokinetics in rats [6].
  • A method of analysis of pterostilbene [trans-3,5-dimethoxy-4'-hydroxystilbene] is necessary to study the kinetics of in vitro and in vivo metabolism and determine its concentration in foodstuffs [6].

Anatomical context of C10287

  • When tested in sensitive cell lines, HL60 and HUT78, 3'-hydroxypterostilbene was 50-97 times more potent than trans-resveratrol in inducing apoptosis, while pterostilbene appeared barely active [1].

Associations of C10287 with other chemical compounds


Gene context of C10287


Analytical, diagnostic and therapeutic context of C10287


  1. Pterostilbene and 3'-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells. Tolomeo, M., Grimaudo, S., Di Cristina, A., Roberti, M., Pizzirani, D., Meli, M., Dusonchet, L., Gebbia, N., Abbadessa, V., Crosta, L., Barucchello, R., Grisolia, G., Invidiata, F., Simoni, D. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  2. The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats. Amarnath Satheesh, M., Pari, L. J. Pharm. Pharmacol. (2006) [Pubmed]
  3. Antihyperglycemic activity of phenolics from Pterocarpus marsupium. Manickam, M., Ramanathan, M., Jahromi, M.A., Chansouria, J.P., Ray, A.B. J. Nat. Prod. (1997) [Pubmed]
  4. Antioxidant activity of hydroxystilbene derivatives in homogeneous solution. Amorati, R., Lucarini, M., Mugnaini, V., Pedulli, G.F., Roberti, M., Pizzirani, D. J. Org. Chem. (2004) [Pubmed]
  5. Selective COX-2 inhibition by a Pterocarpus marsupium extract characterized by pterostilbene, and its activity in healthy human volunteers. Hougee, S., Faber, J., Sanders, A., de Jong, R.B., van den Berg, W.B., Garssen, J., Hoijer, M.A., Smit, H.F. Planta Med. (2005) [Pubmed]
  6. High-performance liquid chromatographic analysis of pterostilbene in biological fluids using fluorescence detection. Remsberg, C.M., Y????ez, J.A., Roupe, K.A., Davies, N.M. Journal of pharmaceutical and biomedical analysis (2007) [Pubmed]
  7. Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats. Pari, L., Satheesh, M.A. Life Sci. (2006) [Pubmed]
  8. Association between pterostilbene and quercetin inhibits metastatic activity of B16 melanoma. Ferrer, P., Asensi, M., Segarra, R., Ortega, A., Benlloch, M., Obrador, E., Varea, M.T., Asensio, G., Jordá, L., Estrela, J.M. Neoplasia (2005) [Pubmed]
  9. Cancer chemopreventive and antioxidant activities of pterostilbene, a naturally occurring analogue of resveratrol. Rimando, A.M., Cuendet, M., Desmarchelier, C., Mehta, R.G., Pezzuto, J.M., Duke, S.O. J. Agric. Food Chem. (2002) [Pubmed]
  10. Pterostilbene, a new agonist for the peroxisome proliferator-activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. Rimando, A.M., Nagmani, R., Feller, D.R., Yokoyama, W. J. Agric. Food Chem. (2005) [Pubmed]
  11. Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India. Paul, B., Masih, I., Deopujari, J., Charpentier, C. Journal of ethnopharmacology. (1999) [Pubmed]
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