Disease relevance of BENCYCLANE

• Effects of bencyclane on concussion following head injury in mice [1].

High impact information on BENCYCLANE

• Bencyclane (5 X 10(-5) mol/l) increased the activities of HK, G-6-P-DH, and LDH, whereas PFK and CCR were reduced [2].
• Protection of oxidative phosphorylation by bencyclane against the damaging effect of mitochondrial swelling [3].
• The effect of bencyclane on the oxidative phosphorylation in isolated mitochondria of heart and liver [4].
• A vasodilating Ca2+ channel blocker, bencyclane, was used in 18 patients with homozygous sickle cell anaemia (SCD) to test the possible anti-sickling effect [5].
• With bencyclane intervention the Na(+)-K+ ATPase activity increased from 256 +/- 29 to 331 +/- 37 nmol Pi/mg protein/h (P < 0.0001) and the Ca(2+)-Mg2+ ATPase level increased from 172 +/- 12 to 222 +/- 44 nmol Pi/mg protein/h (P < 0.0001) [5].

Biological context of BENCYCLANE

• Gas-liquid chromatographic evaluation of bencyclane in biological samples for pharmacokinetic and bioavailability investigations: comparison of two analytical methods [6].
• Bencyclane caused a slight, clinically negligible decrease in blood pressure [7].
• The effect of orally administered bencyclane on spontaneous platelet aggregation (PA) as a function of bencyclane concentration in coded samples [8].
• The pharmacokinetics of bencyclane were studied in 4 healthy volunteers [9].
• Bencyclane decreased, in a use-dependent manner, the maximum rates of depolarization and repolarization (Vmax+ and Vmax-, resp.) of the action potentials both of the train and the volley [10].

Anatomical context of BENCYCLANE

• Effects of cerebral vasodilators such as bencyclane, cinnarizine, and papaverine were comparatively studied using helically cut basilar and superior mesenteric arteries and radial muscle preparations of pulmonary arteries with the sympathetic nerve isolated from rabbits [11].
• Use-dependent blockade of sodium channels induced by bencyclane in frog skeletal muscle and canine cardiac Purkinje fiber [12].
• Characteristic of papaverine is a uniform augmentation of blood supply to the cerebral cortex, the thalamus, and white matter, whereas chloracyzine, and especially bencyclane, primarily augment the blood supply to the cerebral cortex [13].
• Papaverine, drotaverine and bencyclane, drugs considered to have direct action on the smooth muscle, inhibited synaptic transmission in the isolated a sympathetic ganglion of the frog [14].
• In experiments on 100 cats with multichannel recording, the effects of three vasodilators - papaverine, chloracyzine, and bencyclane (Halidor) - on the volume velocity of the blood flow (by microthermistor technique) and on oxygen tension (by polarography) in the carotid artery, the cerebral cortex, the thalamus, and in white matter were tested [13].

Associations of BENCYCLANE with other chemical compounds

• A contribution to the pharmacokinetics of bencyclane (Fludilat) in man [15].
• The quantitative determination of bencyclane from the biological material was carried out with the aid of a combined microchemical method (thin-layer chromatography and measurement of fluorescence) using NBD chloride [15].

Gene context of BENCYCLANE

• The effect of 10(-5) mol/l bencyclane on the repetitive electrical activity of muscle membrane was studied with the conventional microelectrode technique [10].

Analytical, diagnostic and therapeutic context of BENCYCLANE

• Determination of bencyclane in human plasma by means of capillary gas chromatography and nitrogen-phosphorus selective detection [16].
• Radioimmunoassay of bencyclane in human serum [17].
• Applying conventional microelectrode technique, the effect of bencyclane was studied on the maximal rate of rise (Vmax) of the transmembrane action potential in frog skeletal muscle and canine cardiac Purkinje fiber [12].
• In a randomized cross-over design, 35 and 70 mg of bencyclane were infused intravenously and 71 and 143 mg were given orally as a solution in water [9].

References