The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Benoxathian     2-(2,6-dimethoxyphenoxy)-N- (10-oxa-7...

Synonyms: CHEMBL191044, CCG-204320, KST-1B9524, Lopac0_000225, AC1L1DFC, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Psychiatry related information on Benoxathian

  • By contrast, in separate experiments, benoxathian had no effect on stress-induced reduction in open-arm exploratory behavior on the EPMZ, nor on stress-induced plasma ACTH secretion [1].
  • Either the alpha(1)-receptor antagonist benoxathian, or a cocktail of beta(1)- and beta(2)-receptor antagonists (betaxolol+ICI 118,551) blocked the anxiety-like reduction in open-arm exploration on the elevated plus-maze, but not the reduction in social behavior induced in the social interaction test [2].
  • Microinjection of the alpha-1 adrenergic receptor antagonist benoxathian (0, 2.5, 5.0 or 10.0 nmol) into the PVN was found to have no effect on baseline feeding behavior [3].

High impact information on Benoxathian


Biological context of Benoxathian

  • In anaesthetized dogs, i.v. injection of benoxathian (25-100 micrograms/kg), WB 4101 (5-25 micrograms/kg) and prazosin (50 micrograms/kg) produced an immediate fall in diastolic blood pressure, which reached a maximum at about 30 sec after drug administration [9].

Anatomical context of Benoxathian


Gene context of Benoxathian

  • In rats injected with a alpha1 adrenoceptor antagonist, benoxathian, conditioned fear stimuli did not significantly induce the VP, OT or PRL responses [13].

Analytical, diagnostic and therapeutic context of Benoxathian

  • Benoxathian dose dependently blocked the reduction in SI time induced by immobilization stress, whereas beta-receptor antagonists had no effect, consistent with an absence of beta-receptors in CeA [1].
  • Local iontophoresis of the selective alpha2-adrenoceptor antagonists idazoxan or yohimbine but not the selective alpha1 antagonist benoxathian significantly reversed PAG-BIC-evoked inhibition [14].
  • Bilateral microinjection of the alpha(1)-adrenergic receptor antagonist benoxathian into the PVN reduced acute stress-induced adrenocorticotrophic hormone (ACTH) levels by approximately 25% in controls [15].
  • Hypotensive effect in dogs and rats of intravenous injections of the alpha 1-adrenoreceptor antagonist benoxathian [9].


  1. Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress. Cecchi, M., Khoshbouei, H., Morilak, D.A. Neuropharmacology (2002) [Pubmed]
  2. Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Cecchi, M., Khoshbouei, H., Javors, M., Morilak, D.A. Neuroscience (2002) [Pubmed]
  3. Reversal of phenylpropanolamine anorexia in rats by the alpha-1 receptor antagonist benoxathian. Wellman, P.J., Davies, B.T. Pharmacol. Biochem. Behav. (1991) [Pubmed]
  4. Uterine contractile activity stimulates supraoptic neurons in term pregnant rats via a noradrenergic pathway. Douglas, A., Scullion, S., Antonijevic, I., Brown, D., Russell, J., Leng, G. Endocrinology (2001) [Pubmed]
  5. A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype. Madrero, Y., Elorriaga, M., Martinez, S., Noguera, M.A., Cassels, B.K., D'Ocon, P., Ivorra, M.D. Br. J. Pharmacol. (1996) [Pubmed]
  6. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Michel, A.D., Loury, D.N., Whiting, R.L. Br. J. Pharmacol. (1990) [Pubmed]
  7. Alpha 1-adrenoceptor subtypes in bovine prostate. Maruyama, K., Tsuchihashi, H., Baba, S., Mano, F., Nagatomo, T. J. Pharm. Pharmacol. (1992) [Pubmed]
  8. Pharmacological characterization of alpha1- and beta-adrenergic synergism of 5'DII activity in rat brown adipocytes. Raasmaja, A., York, D.A. Arch. Physiol. Biochem. (2006) [Pubmed]
  9. Hypotensive effect in dogs and rats of intravenous injections of the alpha 1-adrenoreceptor antagonist benoxathian. Massi, M., Venturi, F., Brasili, L., Melchiorre, C. Pharmacological research communications. (1986) [Pubmed]
  10. Interruption of central noradrenergic pathways and morphine withdrawal excitation of oxytocin neurones in the rat. Brown, C.H., Murphy, N.P., Munro, G., Ludwig, M., Bull, P.M., Leng, G., Russell, J.A. J. Physiol. (Lond.) (1998) [Pubmed]
  11. Local morphine withdrawal increases c-fos gene, Fos protein, and oxytocin gene expression in hypothalamic magnocellular neurosecretory cells. Johnstone, L.E., Brown, C.H., Meeren, H.K., Vuijst, C.L., Brooks, P.J., Leng, G., Russell, J.A. J. Neurosci. (2000) [Pubmed]
  12. Identification of alpha 1-adrenoceptor subtypes in rat lung by binding of [3H]-prazosin and [3H]-WB4101. Hiramatsu, Y., Muraoka, R., Kigoshi, S., Muramatsu, I. J. Recept. Res. (1994) [Pubmed]
  13. Role of adrenoceptors in vasopressin, oxytocin and prolactin responses to conditioned fear stimuli in the rat. Zou, C.J., Onaka, T., Yagi, K. J. Neuroendocrinol. (1998) [Pubmed]
  14. Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through alpha2-adrenergic receptors. Budai, D., Harasawa, I., Fields, H.L. J. Neurophysiol. (1998) [Pubmed]
  15. Chronic intermittent cold stress sensitises the hypothalamic-pituitary-adrenal response to a novel acute stress by enhancing noradrenergic influence in the rat paraventricular nucleus. Ma, S., Morilak, D.A. J. Neuroendocrinol. (2005) [Pubmed]
WikiGenes - Universities