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Gene Review

Adra1a  -  adrenoceptor alpha 1A

Rattus norvegicus

Synonyms: Adra1c, Alpha-1A adrenergic receptor, Alpha-1A adrenoceptor, Alpha-1A adrenoreceptor, Alpha-1C adrenergic receptor
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Disease relevance of Adra1a

  • Cloning and characterization of the rat alpha 1a-adrenergic receptor gene promoter. Demonstration of cell specificity and regulation by hypoxia [1].
  • CONCLUSIONS: (1) the exacerbation of reperfusion induced arrhythmias by alpha 1 adrenergic stimulation during ischaemia is mediated by the alpha 1A adrenoceptor subtype, and (2) increased Na+/H+ exchanger activity during ischaemia and reperfusion may play a causal role in this phenomenon [2].
  • Inhibition by pretreatment with pertussis toxin is in agreement with involvement of the alpha 1A-adrenoceptor subtype in this Ca(2+)-dependent effect [3].
  • Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia [4].

Psychiatry related information on Adra1a


High impact information on Adra1a


Chemical compound and disease context of Adra1a


Biological context of Adra1a


Anatomical context of Adra1a


Associations of Adra1a with chemical compounds


Physical interactions of Adra1a


Other interactions of Adra1a


Analytical, diagnostic and therapeutic context of Adra1a


  1. Cloning and characterization of the rat alpha 1a-adrenergic receptor gene promoter. Demonstration of cell specificity and regulation by hypoxia. Michelotti, G.A., Bauman, M.J., Smith, M.P., Schwinn, D.A. J. Biol. Chem. (2003) [Pubmed]
  2. Exacerbation of reperfusion arrhythmias by alpha 1 adrenergic stimulation: a potential role for receptor mediated activation of sarcolemmal sodium-hydrogen exchange. Yasutake, M., Avkiran, M. Cardiovasc. Res. (1995) [Pubmed]
  3. Characterization of noradrenaline-stimulated cyclic GMP formation in brain astrocytes in culture. Agulló, L., García, A. Biochem. J. (1992) [Pubmed]
  4. Synthesis and pharmacological characterization of 3-[2-((3aR,9bR)-cis-6-methoxy-2,3,3a,4,5,9b-hexahydro-1H-benz[e] isoindol-2-yl)ethyl]pyrido-[3',4':4,5]thieno[3,2-d]pyrimidine-2,4 (1H,3H)-dione (A-131701): a uroselective alpha 1A adrenoceptor antagonist for the symptomatic treatment of benign prostatic hyperplasia. Meyer, M.D., Altenbach, R.J., Basha, F.Z., Carroll, W.A., Drizin, I., Elmore, S.W., Ehrlich, P.P., Lebold, S.A., Tietje, K., Sippy, K.B., Wendt, M.D., Plata, D.J., Plagge, F., Buckner, S.A., Brune, M.E., Hancock, A.A., Kerwin, J.F. J. Med. Chem. (1997) [Pubmed]
  5. Repeated imipramine and electroconvulsive shock increase alpha 1A-adrenoceptor mRNA level in rat prefrontal cortex. Nalepa, I., Kreiner, G., Kowalska, M., Sanak, M., Zelek-Molik, A., Vetulani, J. Eur. J. Pharmacol. (2002) [Pubmed]
  6. Cloning of the rat alpha 1C-adrenergic receptor from cardiac myocytes. alpha 1C, alpha 1B, and alpha 1D mRNAs are present in cardiac myocytes but not in cardiac fibroblasts. Stewart, A.F., Rokosh, D.G., Bailey, B.A., Karns, L.R., Chang, K.C., Long, C.S., Kariya, K., Simpson, P.C. Circ. Res. (1994) [Pubmed]
  7. Synthesis, absolute configuration, and biological profile of the enantiomers of trans-[2-(2,6-dimethoxyphenoxy)ethyl] [(3-p-tolyl-2,3-dihydro-1,4-benzodioxin-2-yl)methyl]amine (mephendioxan), a potent competitive alpha 1A-adrenoreceptor antagonist. Quaglia, W., Pigini, M., Tayebati, S.K., Piergentili, A., Giannella, M., Leonardi, A., Taddei, C., Melchiorre, C. J. Med. Chem. (1996) [Pubmed]
  8. Coronary artery constriction in rats affects the activation of alpha 1 adrenergic receptors in cardiac myocytes. Cheng, W., Coupet, J., Li, P., Reiss, K., Hamby, C.V., Capasso, J.M., Meggs, L.G., Anversa, P. Cardiovasc. Res. (1994) [Pubmed]
  9. Electroconvulsive shock increases alpha 1b- but not alpha 1a-adrenoceptor binding sites in rat cerebral cortex. Blendy, J.A., Perry, D.C., Pabreza, L.A., Kellar, K.J. J. Neurochem. (1991) [Pubmed]
  10. Systemic alpha 1A-adrenoceptor antagonist inhibits neointimal growth after balloon injury of rat carotid artery. Teeters, J.C., Erami, C., Zhang, H., Faber, J.E. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  11. L-channel modulation by alpha-1 adrenoceptor activation in neonatal rat ventricular cells: intracellular mechanisms. Liu, Q.Y., Karpinski, E., Pang, P.K. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  12. Evidence for an alpha 1-adrenoceptor subtype mediating adrenergic vasoconstriction in Wistar normotensive and stroke-prone spontaneously hypertensive rat kidney. Sattar, M.A., Johns, E.J. J. Cardiovasc. Pharmacol. (1994) [Pubmed]
  13. Characterization of stimulation of phosphoinositide hydrolysis by alpha 1-adrenergic agonists in adult rat hearts. Lazou, A., Fuller, S.J., Bogoyevitch, M.A., Orfali, K.A., Sugden, P.H. Am. J. Physiol. (1994) [Pubmed]
  14. NS-49, an alpha 1A-adrenoceptor agonist, selectively increases intraurethral pressure in dogs. Taniguchi, N., Hamada, K., Ogasawara, T., Ukai, Y., Yoshikuni, Y., Kimura, K. Eur. J. Pharmacol. (1996) [Pubmed]
  15. Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract. Yono, M., Foster, H.E., Shin, D., Takahashi, W., Pouresmail, M., Latifpour, J. Can. J. Physiol. Pharmacol. (2004) [Pubmed]
  16. Tissue distribution of NS-49, a phenethylamine class alpha 1A-adrenoceptor agonist, in pigmented rats. Koike, T., Kitazumi, H., Mukai, H. Arzneimittel-Forschung. (2001) [Pubmed]
  17. Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle. Michel, M.C., Hanft, G., Gross, G. Br. J. Pharmacol. (1994) [Pubmed]
  18. Determination of alpha 1-adrenoceptor subtype selectivity by [3H]-prazosin displacement studies in guinea-pig cerebral cortex and rat spleen membranes. Veenstra, D.M., van Buuren, K.J., Nijkamp, F.P. Br. J. Pharmacol. (1992) [Pubmed]
  19. Identification of a single alpha 1-adrenoceptor corresponding to the alpha 1A-subtype in rat submaxillary gland. Michel, A.D., Loury, D.N., Whiting, R.L. Br. J. Pharmacol. (1989) [Pubmed]
  20. The expression of alpha 1 adrenoceptor subtypes changes with age in the rat aorta. Gurdal, H., Tilakaratne, N., Brown, R.D., Fonseca, M., Friedman, E., Johnson, M.D. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  21. Alpha 1b-adrenoceptors mediate renal tubular sodium and water reabsorption in the rat. Elhawary, A.M., Pang, C.C. Br. J. Pharmacol. (1994) [Pubmed]
  22. Lack of a pharmacological distinction between alpha-1 adrenoceptors mediating intracellular calcium-dependent and independent contractions to sympathetic nerve stimulation in the perfused rat caudal artery. Sulpizio, A., Hieble, J.P. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
  23. Analysis of alpha 1L-adrenoceptor pharmacology in rat small mesenteric artery. Stam, W.B., Van der Graaf, P.H., Saxena, P.R. Br. J. Pharmacol. (1999) [Pubmed]
  24. Effect of electroconvulsive shock on 5-HT2 and alpha 1-adrenoceptors and phosphoinositide signalling system in rat brain. Pandey, G.N., Pandey, S.C., Isaac, L., Davis, J.M. Eur. J. Pharmacol. (1992) [Pubmed]
  25. Alpha 1-adrenoceptor-induced contractility in rat aorta is mediated by the alpha 1D subtype. Buckner, S.A., Oheim, K.W., Morse, P.A., Knepper, S.M., Hancock, A.A. Eur. J. Pharmacol. (1996) [Pubmed]
  26. Functional distribution and role of alpha-1 adrenoceptor subtypes in the mesenteric vasculature of the rat. Kong, J.Q., Taylor, D.A., Fleming, W.W. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  27. 5-HT1A receptors and the tail-flick response. VI. Intrinsic alpha 1A-adrenoceptor antagonist properties can mask the actions of 5-HT1A receptor agonists in the spontaneous tail-flick paradigm. Millan, M.J., Rivet, J.M., Gobert, A., Canton, H., Veiga, S., Bervoets, K. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  28. Synergism between beta 2-adrenoceptor agonists and subtype-selective alpha 1A-adrenoceptor antagonists in the tocolytic effect on pregnant rat uterus in vitro. Mihályi, A., Gáspár, R., Csonka, D., Falkay, G. Clin. Exp. Pharmacol. Physiol. (2003) [Pubmed]
  29. Differential expression of the alpha 1c adrenergic receptor subtype in rat tissues. Alonso-Llamazares, A., Zamanillo, D., Fernández, A., Chinchetru, M.A., Calvo, P. Neuroreport (1993) [Pubmed]
  30. Effects of intrathecal injection of tamsulosin and naftopidil, alpha-1A and -1D adrenergic receptor antagonists, on bladder activity in rats. Sugaya, K., Nishijima, S., Miyazato, M., Ashitomi, K., Hatano, T., Ogawa, Y. Neurosci. Lett. (2002) [Pubmed]
  31. Sustained increase in rat myocardial alpha 1A-adrenoceptors induced by 6-hydroxydopamine treatment involves a decelerated receptor turnover. Sallés, J., Gascón, S., Badia, A. Naunyn Schmiedebergs Arch. Pharmacol. (1996) [Pubmed]
  32. Pharmacokinetics of NS-49, a phenethylamine class alpha 1A-adrenoceptor agonist. 3rd communication: metabolism in rats, rabbits, dogs and monkeys, and effects on hepatic drug-metabolizing enzyme activities in rats after repeated administration. Mukai, H., Watanabe, S., Morino, A. Arzneimittel-Forschung. (1999) [Pubmed]
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