Disease relevance of Dibenzylchlorethamine

• 4. Pretreatment with dibenamine, an irreversible blocker of alpha1 adrenoceptors (0.6 microM for 40 min), abolished this effect, whereas pretreatment with CEC, an irreversible blocker of alpha1b adrenoceptors (1 microM for 20 min), and pertussis toxin (10 microg/kg IP, 4 to 5 days before experiments) diminished it [1].
• Protracted anaphylactic shock of guinea pigs led to death in over 90% of the animals, and good protection was obtained with an infusion of adrenaline after dibenamine pretreatment [2].
• The local intracoronary application of the alpha adrenergic blocking agents phenoxybenzamine or dibenamine, in open chest anesthetized dogs, regularly resulted in maximal coronary vasodilatation thus abolishing reactive hyperemia [3].

High impact information on Dibenzylchlorethamine

• Inactivation of muscarinic receptors on single muscle cells with dibenamine showed that only a small fraction of receptors was responsible for the response to acetylcholine [4].
• Phenoxybenzamine, tolazoline and dibenamine all suppress autoregulation [5].
• The hydrolysis rates of phenoxybenzamine and dibenamine aziridinium ions (2a,b) in physiological medium were found to be 6.0 4 x 10(-4) and 8.35 x 10(-4) sec-1, respectively [6].
• Dibenamine inhibited the contractions comparably in both muscle types and analyses of its partial alkylation of receptors yielded identical estimates of equilibrium dissociation constant (pK(d)) for A-61603 in longitudinal (5.82) and circular (5.84) muscle [7].
• In the presence of strontium hyoscine could be considered a competitive antagonist of acetylcholine for the acetylcholine receptor of the longitudinal muscle of the guinea-pig ileum; dibenamine still blocked this receptor in an irreversible way [8].

Biological context of Dibenzylchlorethamine

• 4. In dogs, azapetine, dibozane and ethomoxane reduced blood pressure, while dibenamine induced an increase in blood pressure and thymoxamine was without effect [9].

Anatomical context of Dibenzylchlorethamine

• Experiments to protect the histamine receptor against dibenamine blockade were carried out to elucidate the pharmacological characteristics of the H2-histamine receptor system for gastric acid secretion in isolated bullfrog gastric mucosa [10].
• Inhibition of cholecystokinin response in the gallbladder by dibenamine and its protection by benzodiazepines [11].
• Schizophrenia - A disturbance of signal interaction between the entorhinal cortex and the dentate gyrus? The contribution of experimental dibenamine psychosis to the pathogenesis of schizophrenia: A hypothesis [12].
• The irreversible inhibitory effects of dibenamine on the noradrenaline-, K- and Ba-induced contractions of rat's isolated vas deferens, particularly in relation to Ca [13].
• Cimetidine pretreatment protected the histamine sensitivity of gastric mucosa from the irreversible blocking action of dibenamine [14].

Associations of Dibenzylchlorethamine with other chemical compounds

• Isoproterenol, in the absence or presence of dibenamine, and endothelin-1 also elicited darkening responses in a dose-related manner, but reaching only 23% and 35% of the maximal darkening, respectively [15].
• Normal tissues showed a sensitivity to agonists at 10(-8)M in order E greater than NE greater than P greater than ISO after treatment with C, I and D, while ganglionectomized tissues revealed a sensitivity to NE greater than P greater than ISO greater than E, even though the quantitative response after C, I and D was reduced [16].
• Fasting, adrenalectomy, and pretreatment with alpha- and beta-adrenergic antagonists (dibenamine and propranolol) eliminated the ethanol-induced hyperglycemic response [17].
• These results suggest that cocaine-induced increase in calcium influx from extracellular fluid is selectively inhibited by dibenamine [18].
• It is assumed that Verapamil acts mainly by preventing excessive calcium influx in cardiomyocytes, whereas Dibenamine improves the microcirculation, which is deficient during the necrotizing phase of the polymyopathy [19].

Gene context of Dibenzylchlorethamine

• Phenoxybenzamine and dibenamine inhibited calmodulin activity irreversibly, whereas the inhibition caused by other alpha adrenergic blocking agents was reversible [20].

References